"Since eliminating gluten and dairy, I've noticed significant improvements in gut issues I had dealt with for a while. My acne has also improved noticeably."

— Kellen | PlexusDx Genetic Methylation Test | November 2025

Product: Genetic Methylation Test  |  Health Focus: Methylation & Gut Health  |  PlexusDx Customer Since: 2025

The Challenge

Kellen came to PlexusDx with a specific goal: confirm whether he carried the MTHFR gene variant. He had been managing ongoing gut issues without a clear explanation and wanted answers rooted in his own biology rather than generalized health advice. He also wanted to make smarter supplement decisions — but without knowing his genetic profile, every choice felt like guesswork.

What the Test Revealed

The results confirmed what Kellen had suspected: he does carry the MTHFR mutation. Understanding this variant gave him immediate clarity on how his body processes B vitamins and folate, and what that means for supplement selection. But the test revealed more than he came looking for. The report also identified genetic sensitivities to both gluten and dairy — findings he hadn't been seeking, but that proved equally consequential. Rather than presenting raw data, the PlexusDx Results Portal framed everything as actionable direction — a quality Kellen specifically noted and appreciated.

What Changed

With his results in hand, Kellen made targeted adjustments aligned with what his genetics revealed:

  • Removed gluten from his diet based on his identified genetic sensitivity
  • Removed dairy from his diet based on his identified genetic sensitivity
  • Became more intentional about supplement choices in light of his confirmed MTHFR mutation

The Outcome

Results arrived on more than one front. After eliminating gluten and dairy, Kellen noticed significant improvements in the gut issues he had managed for years. A second, unexpected benefit followed: his acne improved noticeably. Confirming his MTHFR status gave him peace of mind and a renewed confidence in how he supports his health day to day. The test didn't just answer the question he walked in with — it gave him a clearer direction he didn't know he was missing.

In Their Own Words

"I originally ordered PlexusDx specifically to check my MTHFR gene status, and it delivered exactly what I was looking for. Finding out that I do have an MTHFR mutation was extremely helpful because it gave me clarity around how I approach supplementation and overall health. Beyond that, I was surprised by how detailed and insightful the rest of the reports were. The portal made everything easy to understand and actionable instead of overwhelming. It felt like I wasn't just getting raw data — I was getting direction. After reviewing my results, I decided to remove gluten and dairy from my diet because the report indicated I was likely sensitive to both. Since eliminating gluten and dairy, I've noticed significant improvements in gut issues I had dealt with for a while. My acne has also improved noticeably."

— Kellen, PlexusDx Customer | November 2025

Results reflect Kellen's personal experience with PlexusDx genetic testing. Individual results will vary. PlexusDx genetic tests are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before making changes to your supplement or nutrition regimen.

Ready to understand what your genes say about your methylation and gut health? Explore the Genetic Methylation Test →

Frequently Asked Questions

Does the PlexusDx Genetic Methylation Test identify MTHFR mutations?

Yes. MTHFR variant analysis is a core component of the Genetic Methylation Test. If you carry this variant, your report will explain what it means for how your body processes folate and B vitamins — and what dietary and supplement strategies may best support your methylation function. Kellen specifically ordered the test to confirm his MTHFR status, and the results delivered exactly that, along with additional insights he hadn't anticipated.

Can removing gluten and dairy improve gut health based on genetic results?

For people with genetically indicated food sensitivities, dietary changes can be meaningful — even when those sensitivities haven't produced obvious allergic reactions. The Genetic Methylation Test includes markers related to gluten and dairy sensitivity among other food-related genetic tendencies. When Kellen removed both based on his results, he noticed significant improvements in gut issues he had managed for years. Genetic food sensitivities are distinct from clinical allergies, but they can meaningfully influence how your digestive system responds to certain foods over time.

How does knowing your MTHFR status change how you approach supplementation?

The MTHFR gene plays a direct role in how your body converts folic acid and certain B vitamins into their active, usable forms. People with MTHFR variants often process synthetic folic acid less efficiently, which is why methylated forms — such as methylfolate and methylcobalamin — are frequently recommended instead of standard versions. Understanding your MTHFR status, as Kellen did, allows you to make more targeted supplement decisions rather than defaulting to whatever is most commonly marketed. Your PlexusDx results will outline specific strategies aligned with your unique genetic profile.