PlexusDx DNA test kit with smartphone displaying genetic results on a white background
PlexusDx Functional Health Genetic Test kit box — most comprehensive DNA test with 750+ insights across 10 health domains
Targeted DNA recommendations: personalized diet, supplement, and lifestyle insights based on your unique genetic results
How PlexusDx at-home DNA testing works: order online, swab at home, receive personalized genetic health reports
Your privacy is PlexusDx number one priority: HIPAA-compliant security, advanced encryption, data never sold or shared

Functional Health Genetic Test

One cheek swab. 767 genetic insights across 10 reports and six areas of whole-body health.

$398.00

One cheek swab, 767 DNA insights across methylation, nutrition, weight, fitness, hormones, and longevity.

All 10 PlexusDx reports in one test. The most complete picture of your DNA, delivered together in your Results Portal.

Built for action, not raw data. Plain-English insights with personalized nutrition, supplement, and lifestyle suggestions.

Genetic tendencies, not a diagnosis.

One test for life. Your DNA never changes.

Genetic Tests are a one-time purchase

Optional interest-free financing available. One-time purchase.

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Overview
767
genetic insights
10
genetic reports
322
genes
6
focus areas

The Functional Health Genetic Test analyzes your DNA to deliver 760+ genetic insights across 10 reports, covering methylation and detox, nutrition, weight, fitness, hormones, and longevity and heart health.

Genes in this test
MTHFRCOMTCBSGSTP1CYP1A1NQO1
Focus areas
Methylation, detox & cellular processingNutrition, vitamins & food responseWeight, appetite & metabolic responseFitness, performance & recoveryHormones, thyroid & fertilityLongevity, heart & healthy aging
Reports included
Methylation Pathway Genetic ReportDetoxification Genetic ReportDiet & Nutrition Genetic ReportWeight & Body Fat Genetic ReportFitness & Injury Genetic ReportAllergies & Food Sensitivities Genetic ReportHormone & Fertility Genetic Report (Men's or Women's)Longevity & Lifespan Genetic ReportHealthy Aging Genetic ReportCardiometabolic Genetic Report
HIPAA-compliant platform
Data never sold
One test for life
What you'll learn

What your DNA reveals in this test

Methylation, detox & cellular processing

How your genes may shape methylation, the transsulfuration pathway, and the two phases of detox your body uses to process everyday compounds. The well-known MTHFR gene sits here.

Nutrition, vitamins & food response

How well your body absorbs vitamins and minerals, responds to different foods and diet types, and handles histamine and common food triggers.

Weight, appetite & metabolic response

How your genes may shape hunger, fullness, fat storage, blood sugar handling, and the way your body responds to losing weight and keeping it off.

Fitness, performance & recovery

How your genes may shape endurance versus power, mitochondrial energy, training response, and how your body recovers from exercise.

Hormones, thyroid & fertility

How your genes may shape estrogen, progesterone, and testosterone balance, thyroid hormone activity, and fertility-related pathways, for context to review with your provider.

Longevity, heart & healthy aging

How your genes may shape cellular aging and telomere maintenance, inflammation, heart and cardiovascular balance, and joint, bone, and skin resilience. Context, not a diagnosis.

What this test covers

This test analyzes your DNA across all 10 PlexusDx genetic reports: 767 markers across 176 traits, grouped into the six areas below.

Methylation, detox & cellular processing

How your genes may shape methylation, the transsulfuration pathway, and the two phases of detox your body uses to process everyday compounds. The well-known MTHFR gene sits here for folate handling, alongside COMT and CBS for methylation and GSTP1 for conjugation.

Folate and methylationTranssulfurationPhase 1 activationPhase 2 conjugationEveryday compound processingAntioxidant defense
Featured genesMTHFRCOMTCBSGSTP1CYP1A1NQO1

Nutrition, vitamins & food response

How well your body absorbs and uses vitamins and minerals, how you respond to different foods and diet types, and how you handle histamine and common food triggers. This area includes VDR for vitamin D, HFE for iron, and AOC1 for histamine breakdown.

Vitamins and mineralsMacronutrient responseDiet-type responseFood sensitivitiesHistamine and intoleranceMicrobiome
Featured genesVDRHFEFUT2FTOHLA-DQB1AOC1

Weight, appetite & metabolic response

How your genes may shape hunger, fullness, fat storage, blood sugar handling, and the way your body responds to losing weight and keeping it off. This area includes the well-known FTO gene, MC4R for appetite, and TCF7L2 for blood sugar response.

Hunger and fullnessSnackingFat storage and distributionBlood sugarWeight loss and regain
Featured genesFTOMC4RPPARGTCF7L2LEPRADIPOQ

Fitness, performance & recovery

How your genes may shape endurance versus power, mitochondrial energy production, training response, and how your body recovers from exercise. This area includes the well-studied ACTN3 power gene, PPARGC1A for mitochondrial energy, and COL5A1 for tendon resilience.

EndurancePower and strengthMitochondrial energyRecoveryInjury and tendon resilience
Featured genesACTN3ACEPPARGC1ACOL5A1VEGFAMMP3

Hormones, thyroid & fertility

How your genes may shape estrogen, progesterone, and testosterone balance, thyroid hormone activity, and fertility-related pathways. This area includes SHBG for free testosterone, CYP19A1 for estrogen production, and DIO2 for the T4-to-T3 conversion behind your metabolic pace.

Estrogen balanceProgesteroneTestosteroneThyroid hormone activityFertility-related pathwaysCycle-related symptoms
Featured genesSHBGCYP19A1COMTDIO2FSHRPGR

Longevity, heart & healthy aging

How your genes may shape cellular aging, telomere maintenance, inflammation, and heart and cardiovascular balance, along with joint, bone, and skin resilience as you age. This area includes FOXO3 and SIRT1 for cellular aging, TERT for telomere maintenance, and APOB and PCSK9 for cholesterol handling.

Cellular aging and longevityTelomere maintenanceInflammationHeart and cardiovascular healthJoint and bone resilienceSkin aging
Featured genesFOXO3SIRT1TERTAPOBPCSK9NOS3

You do not have to act on all of it. Pick one or two areas, talk them over with your doctor, and build from there. This test shows genetic tendencies, not a diagnosis. It does not diagnose, treat, or predict any condition, and it does not guarantee any specific outcome.

How it works

From kit to results in four steps

1

Order your kit

We ship your DNA collection kit to your door for free, in discreet packaging.

2

Register and swab at home

Register your kit online with the included instructions, then take a quick, painless cheek swab. No needles, no clinic visit.

3

Mail it back

Seal your sample in the prepaid return envelope and drop it in the mail. Our CLIA-certified lab analyzes your DNA on the Illumina Global Screening Array.

4

Get your reports

In about 2 to 4 weeks, your reports and personalized guidance appear in your PlexusDx Results Portal.

Is this test right for you?
Who it's for
You are starting with your DNA and want one cheek swab to cover your whole body, from methylation and nutrition to hormones and longevity.
You are juggling several goals at once, like weight, energy, hormones, and healthy aging, and want them in one place.
You want personalized nutrition, supplement, and lifestyle context built on your genetics, not generic advice.
You want one test for life, since your DNA results never expire and new reports keep adding value.
You want a DNA foundation to discuss with your provider and to pair with blood testing.
What it is not
A diagnostic test. It does not diagnose, treat, cure, or prevent any condition.
A measure of your current nutrient, hormone, or toxin levels. It reflects genetic tendencies and processing capacity, not exposure.
A promise of any specific health outcome. Your genes are one factor among many, including diet, activity, sleep, and overall health.
The right starting point if you already have PlexusDx DNA on file. In that case, add the individual reports from your Results Portal instead.
What you receive

Everything included with your test

Ten genetic reports

All 10 PlexusDx genetic reports, from methylation and nutrition to hormones and longevity, delivered together in your Results Portal.

An at-home swab kit

The cheek swab, collection vial, and a prepaid return envelope, with free shipping both ways.

Plain-English insights

Your results in clear language, with personalized nutrition, supplement, and lifestyle suggestions and discussion points for your provider.

One swab, 767 insights

A single cheek swab covers all 767 insights across your reports. Your DNA does not change, so you test once.

Your ecosystem

The reports inside this test

Each one is a full PlexusDx genetic report. Explore what they cover.

Methylation Pathway Genetic Report

How your genes may shape methylation, folate handling, detox support, and the one-carbon pathways behind energy and mood.

View report

Detoxification Genetic Report

How your genes may shape Phase 1 and Phase 2 detox and your capacity to process everyday compounds and environmental exposures.

View report

Diet & Nutrition Genetic Report

How your genes may shape the way you process vitamins, minerals, fats, and carbs, with diet-type and supplement context.

View report

Weight & Body Fat Genetic Report

How your genes may shape appetite, fat storage, blood sugar response, and how your body loses weight and keeps it off.

View report

Fitness & Injury Genetic Report

How your genes may shape endurance, power, training response, recovery, and injury and tendon resilience.

View report

Allergies & Food Sensitivities Genetic Report

How your genes may shape food and environmental sensitivities, histamine handling, and immune reactivity.

View report

Hormone & Fertility Genetic Report (Men's or Women's)

How your genes may shape estrogen, progesterone, and testosterone balance, thyroid activity, and fertility-related pathways. You receive the report matched to your biological sex.

View report

Longevity & Lifespan Genetic Report

How your genes may shape cellular aging, telomere maintenance, NAD+ pathways, and the biology behind healthy lifespan.

View report

Healthy Aging Genetic Report

How your genes may shape inflammation, joint and bone resilience, skin aging, and sensory and metabolic changes over time.

View report

Cardiometabolic Genetic Report

How your genes may shape heart and artery health, blood pressure, cholesterol and triglycerides, blood sugar, and clotting.

View report

All your reports live in one place: your PlexusDx Results Portal, alongside any other PlexusDx tests and reports you own. One login, your whole genetic picture.

PlexusDx tests and reports are for wellness and educational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. Results are delivered through the PlexusDx Results Portal.

Built on your DNA

One cheek swab unlocks 767 DNA insights across your whole body.

$398

Order My Test

Free shipping both ways. One test for life.

Good to know

Frequently asked questions

What does the Functional Health Genetic Test analyze?

It reads 767 genetic insights from a single cheek swab across 10 reports and six areas of health: methylation and detox, nutrition, weight, fitness, hormones and thyroid, and longevity and heart health. You get one whole-body view of your DNA.

How is this different from buying the reports separately?

This test bundles all 10 PlexusDx genetic reports into one kit at one price, so you get the full 767-insight picture instead of one area at a time. Everything lives together in your Results Portal, where patterns across nutrition, hormones, and metabolism are easier to see.

What do I receive, and how long does it take?

You receive a cheek-swab kit with a prepaid return envelope. After our CLIA-certified lab processes your sample on the Illumina Global Screening Array, your results are ready in the Results Portal in about 2 to 4 weeks, with all 10 reports and personalized suggestions. Minors can be tested when a parent or guardian registers and oversees the kit.

Is this a medical or diagnostic test?

No. The Functional Health Genetic Test is for education and wellness, not diagnosis. It shows genetic tendencies, not a diagnosis or a prediction of disease. Always talk with a qualified healthcare provider before making medical decisions or changing medications.

Which genes does the test actually look at?

It analyzes 335 genes across methylation and detox (MTHFR, COMT, CBS, GSTP1), nutrition (VDR, HFE, FTO), weight and metabolism (MC4R, PPARG, TCF7L2), fitness (ACTN3, PPARGC1A), hormones and thyroid (SHBG, CYP19A1, DIO2), and longevity and heart health (FOXO3, SIRT1, TERT, APOB). Each insight reflects genetic capacity, not exposure or diagnosis.