Safety Information

Last updated October 15, 2026

Safety belongs at the center of treatment.

This page provides general educational information about compounded GLP-1 medications for weight management and other compounded medications that Lone Star's clinicians may prescribe through PlexusDx, such as NAD+, sermorelin, PT-141 (bremelanotide), glutathione, lipotropic injections, GHK-Cu cream, and ondansetron. It does not replace individualized medical advice, prescribing information, a medication guide, or instructions from your treating clinician and dispensing pharmacy.

Compounded medications are not FDA-approved.

FDA does not review compounded drugs for safety, effectiveness, or quality before marketing.

PlexusDx is not an emergency service

If you are experiencing a medical emergency, call 911 or seek immediate in-person emergency care. For urgent medication-specific questions, contact your treating clinician or dispensing pharmacy.

Share your complete medical history

Tell your clinician about current and prior medical conditions, allergies, pregnancy or plans for pregnancy, prior reactions to medications, and every prescription medicine, over-the-counter medicine, and supplement you take. Eligibility and treatment decisions depend on accurate information.

Not everyone is a candidate

An independent licensed healthcare professional determines whether treatment is medically appropriate after reviewing the information you provide. A specific medication, formulation, or dose is never guaranteed.

GLP-1 medications: common side effects

GLP-1-based medications can cause gastrointestinal and other side effects. Commonly reported effects include nausea, vomiting, diarrhea, constipation, abdominal discomfort, decreased appetite, and related gastrointestinal symptoms. This is not a complete list.

Other compounded medications

None of the compounded medications below is FDA-approved, and FDA has not approved any of them for wellness, energy, or healthy aging. Tell your clinician about every health condition and medicine before you start, and contact your clinician if you have a reaction.

PT-141 (bremelanotide)

The FDA-approved version of bremelanotide, Vyleesi, is approved only for premenopausal women with acquired, generalized hypoactive sexual desire disorder. Compounded PT-141 is not FDA-approved. In the approved drug's studies, the most common side effects were nausea, reported by 40% of patients, flushing, injection-site reactions, headache, and vomiting. Each dose briefly raises blood pressure and lowers heart rate, so it should not be used by people with uncontrolled high blood pressure or known heart or blood vessel disease. It can cause darker patches of skin, more often with frequent doses, and the patches may not go away after you stop. The label says it is not recommended for people at high risk for heart disease. The approved drug's label says not to use more than one dose in 24 hours and that more than eight doses a month is not recommended. The label says to avoid using it with naltrexone taken by mouth, because naltrexone may not work as well, and notes that it can slow how quickly some medicines taken by mouth are absorbed. Stop and contact your clinician if you could be pregnant.

Sermorelin

Sermorelin is a laboratory-made version of part of the hormone that signals the pituitary gland to release growth hormone. A sermorelin product, Geref, was once FDA-approved; compounded sermorelin is not. Irish product information for Geref 50, a single injection used to test pituitary function, lists facial warmth or flushing and pain at the injection site, says it should not be used by people allergic to sermorelin or its ingredients or during pregnancy or breastfeeding, and advises caution in people with diabetes or epilepsy. Tell your clinician if you have diabetes, epilepsy, or a thyroid condition, or if you take growth hormone.

NAD+ and glutathione injections

FDA has not approved NAD+ or glutathione injections, so there is no FDA prescribing information for them, and published safety information in people is limited. In 2026, CDC investigated illnesses, including fever, chills, low blood pressure, and some hospitalizations, after glutathione injections made with dietary-supplement-grade ingredients, which are not meant for injection. Report any injection-site reaction or new symptom to your clinician.

Lipotropic injections (MIC with vitamin B12, and Lipo-C)

These injections combine methionine, inositol, and choline (MIC) with vitamin B12. Lipo-C also contains L-carnitine and other B vitamins. No MIC or Lipo-C injection is FDA-approved. The prescribing information for FDA-approved vitamin B12 (cyanocobalamin) injection says it should not be used by people sensitive to cobalt or vitamin B12, reports severe allergic reactions after B12 injections, including anaphylaxis that was sometimes fatal, and warns that people with early Leber's disease, an inherited eye condition, developed rapid optic nerve damage after treatment. The label for FDA-approved levocarnitine (L-carnitine) reports seizures in people with or without a history of seizures, as well as nausea and vomiting. Formulas differ by pharmacy, and there is no FDA prescribing information for these combination injections, so check the ingredient list on your label. Tell your clinician if any of these apply to you, including any history of seizures.

GHK-Cu cream

GHK-Cu is a copper peptide applied to the skin. FDA has not approved any GHK-Cu product, and published safety information is limited. Use it only on the skin as directed, and stop and contact your clinician if you get a rash, itching, or irritation.

Ondansetron

Ondansetron is an anti-nausea medicine. FDA-approved ondansetron, sold as Zofran and as generics, is approved to prevent nausea and vomiting from chemotherapy, radiation, and surgery; compounded ondansetron is not FDA-approved. The approved drug's label warns of allergic reactions, including anaphylaxis; changes in heart rhythm (QT prolongation); serotonin syndrome; and reports of reduced blood flow to the heart. It says not to take ondansetron if you are allergic to it or any of its ingredients, or with apomorphine. It can hide signs of a blocked or slowed bowel, so tell your clinician if you have a swollen belly, severe belly pain, or cannot pass stool or gas. Common side effects include headache, tiredness, constipation, and diarrhea. Zofran's orally disintegrating tablets contain phenylalanine, so if you have phenylketonuria, ask your pharmacy whether your product does. Tell your clinician if you have a heart rhythm problem, long QT syndrome, heart failure, or low potassium or magnesium, or take medicines that affect heart rhythm or serotonin, such as antidepressants.

Injections at home

Use only the medication your pharmacy dispensed for you, and follow its label and your clinician's instructions for dose, storage, and beyond-use date. Inject only the way your label says. Do not inject into a vein unless the label says the product is made for that, and do not use a vial that is cloudy, discolored, or leaking or has particles in it unless your label says that is normal. Use a new sterile needle and syringe for each injection; never share needles, syringes, or vials; and put used needles in a sharps disposal container. Redness, swelling, or mild pain where you inject can happen. Contact your clinician if redness spreads, the area becomes warm or drains, or you develop a fever, which can be signs of infection. Contaminated injections can cause fever, chills, body aches, dizziness, low blood pressure, or shock; get emergency care if these start after an injection. Call 911 for signs of a severe allergic reaction, such as trouble breathing or swelling of the face, lips, tongue, or throat.

Serious symptoms require prompt attention

Contact your clinician promptly for persistent, worsening, or concerning symptoms. Seek urgent or emergency care for symptoms that may be severe or life-threatening, including severe or persistent abdominal pain, inability to keep fluids down, signs of serious dehydration, severe allergic reaction, or other symptoms that feel emergent.

Follow the prescribed dose

Do not independently increase, decrease, skip, combine, or otherwise alter your prescribed treatment plan without discussing the change with the treating clinician. Dose changes and medication switches require clinical approval.

Medication storage and delivery

Follow the dispensing pharmacy's instructions for storage and handling. If a shipment arrives damaged, missing, unusually warm, or otherwise concerning, report the issue promptly and generally within 24 hours after the carrier-recorded delivery time. Do not rely on general support staff to determine whether a medication remains clinically appropriate to use.

Report side effects

Report side effects to your clinician. You can also report them to FDA's MedWatch program at 1-800-FDA-1088 or www.fda.gov/medwatch.

Telehealth has limits

Telehealth cannot replace every physical examination, diagnostic test, or urgent evaluation. Your clinician may recommend laboratory testing, in-person evaluation, emergency care, or another treatment approach when appropriate.

Who does what

PlexusDx operates the technology and administrative platform. Independent licensed clinicians make medical decisions and issue prescriptions when appropriate. Licensed partner pharmacies are responsible for pharmacy preparation, dispensing, labeling, counseling, and medication fulfillment. Clinical services are provided by Lone Star Virtual Health, and the telehealth platform is Bask Health.

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