Brello Health vs PlexusDx: GLP-1 cost, reviews (2026)
Brello's 3-month plans cost $499 for tirzepatide and $399 for semaglutide; PlexusDx's are $507 and $387, all billed up front (Nov 4, 2026). PlexusDx sells an at-home GLP-1 & Peptide Pathways Genetic Test and blood tests, and offers a free 15-minute PharmD consult.
Brello reviews: 4.3/5 on Trustpilot (4,560 reviews) · F from the BBB
| Checkout price | PlexusDx | Brello |
|---|---|---|
| Tirzepatide 3-month plan | $507 up front ($169/mo) | $499 up front |
| Tirzepatide 6-month plan | $894 up front ($149/mo) | $894 up front |
| Semaglutide 3-month plan | $387 up front ($129/mo) | $399 up front |
| Semaglutide month to month | $149/mo | No monthly plan "All plans have a 3-month minimum" |
- Genetic test
- PlexusDx: At-home GLP-1 & Peptide Pathways Genetic Test, sold separately
- Brello: None on the plan pages we walked
- Blood tests
- PlexusDx: At-home blood tests, sold separately
- Brello: None on the plan pages we walked
- Plan lengths
- PlexusDx: 1, 3, 6 or 12 months
- Brello: 3 months, or 6 months for tirzepatide
- When you're charged
- PlexusDx: When your prescription goes to the pharmacy
- Brello: At checkout, before its online intake; a full refund if you aren't approved
- Same at both
- No separate membership fee · Same price at every dose · Shipping included
What else PlexusDx offers
GLP-1 & Peptide Pathways Genetic Test
150+ genetic insights across 14 health pathways.
$298, or $99 for program members.
See the test →At-home blood tests from $129
Plus supplement packs from $79, built from your results.
See blood tests →The GLP-1 & Peptide Pathways Genetic Test does not select or predict a medication; your provider decides.
What do Brello's reviews say?
On Nov 4, 2026, 68% of Brello's Trustpilot reviews gave five stars, while its BBB customer reviews averaged 1.67 out of 5.
Trustpilot
68% five-star · 15% one-star
- 2,072 reviews in the past 12 months.
- Replied to 100% of negative reviews; typically replies within 24 hours.
- Asks customers to review.
- Reviews on its newest page mostly praise easy sign-up, fast shipping, phone support and the community; one-star reviews mention 3-month supplies that expired before they were used up, and warm shipments.
BBB
F, not accredited
- 52 complaints in the past 3 years, 34 in the past 12 months.
- 42 complaints with no response from the business.
- BBB customer reviews average 1.67 out of 5 across 30.
- Complaints on its first page include 3-month supplies that expired before they were used up, and warm or missing shipments; all 10 are marked unanswered.
Both read at source on Nov 4, 2026. Ratings belong to the platforms, not to PlexusDx.
What do longer plans cost at PlexusDx?
PlexusDx semaglutide is $99 a month on a 12-month plan ($1,188 up front), and tirzepatide $129 a month ($1,548 up front), as of Nov 4, 2026.
| PlexusDx plan | Month to month | 3 months | 6 months | 12 months |
|---|---|---|---|---|
| Semaglutide | $149/mo | $129/mo $387 up front | $109/mo $654 up front | $99/mo $1,188 up front |
| Tirzepatide | $189/mo | $169/mo $507 up front | $149/mo $894 up front | $129/mo $1,548 up front |
| Microdose (semaglutide or tirzepatide) | $99/mo | $89/mo $267 up front | $79/mo $474 up front | $69/mo $828 up front |
Is Brello or PlexusDx better?
PlexusDx sells the at-home GLP-1 & Peptide Pathways Genetic Test and blood tests and offers a free PharmD consult; Brello includes classes and an online community in its plans.
Choose Brello if…
- You want 3 months of tirzepatide for $8 less ($499 against $507).
- You want virtual fitness and nutrition classes and a private online community included in your plan.
Choose PlexusDx if…
- You want the at-home GLP-1 & Peptide Pathways Genetic Test, sold separately.
- You want at-home blood tests, sold separately.
- You want a free 15-minute consult with Dr. Jayden Lee, PharmD, by video or phone.
- You want a month-to-month plan, a 12-month plan, or a 6-month semaglutide plan.
How do Brello and PlexusDx compare on cancelling, support and formats?
Both renew automatically until you cancel.
Read on Nov 4, 2026 from each company's own pages.
- Cancelling
- PlexusDx: Turn off renewal in your patient portal before the next charge
- Brello: Stop renewals in your online account at least 2 business days before your next billing date, its Checkout Terms say
- Support
- PlexusDx: 24/7 support and clinical chat
- Brello: Phone support and a clinical chat in your patient dashboard, its help center says
- Formats
- PlexusDx: Injection, including a microdose program
- Brello: Semaglutide or tirzepatide injection, on the plan pages we walked
- Same at both
- Compounded medication, included in the plan price
How does compounded GLP-1 telehealth work?
You complete an online intake, a licensed provider reviews it, and if treatment is appropriate a state-licensed 503A pharmacy prepares and ships your medication, with no in-person visit.
At both PlexusDx and Brello, a provider reviews an online intake before anything is prescribed. In the PlexusDx program, a 503A compounding pharmacy, a state-licensed facility that prepares medication for one patient from a valid prescription, fills the prescription and ships it to your door.
Compounded medications are not FDA-approved and are not reviewed by the FDA for safety, quality, or effectiveness. They are a legal, provider-prescribed option prepared by a licensed pharmacy, not a generic or a substitute the FDA has evaluated.
How did we check these prices and reviews?
We walked Brello's plan pages for both drugs to the plan choice on Nov 3, 2026, without paying, and on Nov 4 read them again with its Checkout Terms, refund policy, Terms, help center, Trustpilot and BBB pages.
We recorded every plan Brello lists for both drugs. The tables show each company's checkout price; for Brello, the amount its plan pages show as billed today, the same prices its Checkout Terms list. PlexusDx prices come from our product pages on Nov 4.
Who wrote this. The PlexusDx editorial team wrote this page, and Dr. Jayden Lee, PharmD, reviewed it for accuracy.
Our bias. PlexusDx publishes this page and is one of the two programs compared. We show where Brello is ahead, and we update the page when either company changes its prices.
- Brello's website (brellohealth.com)
- Brello's 3-month tirzepatide plan page
- Brello's 6-month tirzepatide plan page
- Brello's semaglutide plan page
- Brello's Checkout Terms
- Brello's refund policy
- Brello's Terms and Conditions
- Brello's help center
- Brello Health on Trustpilot
- Brello Health on the BBB
- PlexusDx semaglutide injection
- PlexusDx tirzepatide injection
- PlexusDx refund and cancellation policy
- PlexusDx microdose GLP-1
Ready to start with PlexusDx?
PlexusDx semaglutide is $149 month to month or $99/mo on a 12-month plan; tirzepatide is $189 or $129/mo.
A licensed provider reviews your intake before anything is prescribed.
Start your online visitOr book a free 15-minute consult with Dr. Jayden Lee, PharmDFrequently Asked Questions
How much does Brello tirzepatide cost?
Brello's compounded tirzepatide is $499 for a 3-month plan or $894 for a 6-month plan, billed at checkout (Nov 4, 2026). Every Brello plan has "a 3-month minimum," its homepage says. PlexusDx tirzepatide is $507 for 3 months or $894 for 6 months, billed up front, or $189 month to month.
How much does Brello cost a month?
Every Brello plan has a 3-month minimum: $399 for 3 months of semaglutide and $499 for 3 months of tirzepatide, billed at checkout (Nov 4, 2026). PlexusDx's 3-month plans are $387 and $507, billed up front, and it also offers month-to-month plans at $149 for semaglutide and $189 for tirzepatide.
Is Brello cheaper than PlexusDx?
Partly: Brello's 3-month tirzepatide is $8 less ($499 against $507), PlexusDx's 3-month semaglutide is $12 less ($387 against $399), and 6-month tirzepatide is $894 at both (Nov 4, 2026). PlexusDx sells the GLP-1 & Peptide Pathways Genetic Test and at-home blood tests, and offers a free 15-minute consult with Dr. Jayden Lee, PharmD, by video or phone.
Does Brello have a membership fee?
No: "There are no additional membership fees required within these plans," Brello's help center says (Nov 4, 2026). Its plan price includes the medication if you are approved, the provider review, shipping, virtual fitness and nutrition classes and a private online community. PlexusDx has no membership fee; its plan price covers the provider, prescription, medication and shipping.
Is Brello's GLP-1 medication compounded?
Yes. Brello's plans are for compounded semaglutide and compounded tirzepatide, as its plan pages and Checkout Terms name them (Nov 4, 2026). Its pages say compounded drugs are not FDA-approved. PlexusDx semaglutide and tirzepatide are compounded too and are not FDA-approved; in the PlexusDx program, licensed 503A pharmacies fill prescriptions.
Does Brello's price go up with dose?
No: "No hikes if your dosage changes," Brello's plan page says (Nov 4, 2026). Its Checkout Terms list one price for each plan. At PlexusDx, your dose may need to go up; your price won't.
When does Brello charge your card?
Brello charges at checkout, before its online intake (Nov 4, 2026). Its plan pages say "After checkout, you'll complete an online intake form" and "Not approved? You'll receive a full refund." At PlexusDx, cards are charged once your prescription is sent to the pharmacy.
Can you get a refund from Brello?
Brello gives a full refund if you cancel before its provider review or aren't approved; after a prescription, it refunds all but a $50 fee if you cancel in time (Nov 4, 2026). Medication that has left the pharmacy isn't refunded. PlexusDx gives a full refund if you cancel after approval and before your prescription is sent to the pharmacy.
How do I cancel Brello?
Stop future renewals in your Brello account at least 2 business days before your next billing date, its Checkout Terms say (Nov 4, 2026). Stopping renewals does not refund an order already placed. With PlexusDx, you turn off renewal in your patient portal before the next charge.
Is Brello Health legit?
Brello Health (brellohealth.com) is an operating telehealth brand run by Brello LLC of Houston, Texas. As of Nov 4, 2026, Trustpilot rated it 4.3 out of 5 across 4,560 reviews, while the BBB rated it F and not accredited, with 52 complaints in three years.
Can I talk to a pharmacist?
Yes. PlexusDx offers a free 15-minute consult with Dr. Jayden Lee, PharmD, by video or phone. It is education and support; a licensed provider makes any prescribing decision.
What does the PlexusDx genetic test do?
The GLP-1 & Peptide Pathways Genetic Test shows how your genes relate to weight management and other peptide-related pathways, with 150+ genetic insights across 14 health pathways from one swab. It does not select or predict a medication; your provider decides. It costs $298, or $99 for program members, and is sold separately from any GLP-1 plan.
PlexusDx tells you about your biology. It does not tell you what to put in your body.
