The BHMT gene helps recycle homocysteine into methionine using betaine, and the common variant rs3733890 (R239Q) can subtly shape that pathway. Learn what BHMT does, what rs3733890 represents, how it connects to MTHFR and methylation, and how pathway-level genetic reports add context.

Calcium oxalate is the most common kidney stone, and genes shape how much oxalate you make and absorb. AGXT drives rare primary hyperoxaluria, while common variants in SLC26A6 and CLDN14 affect everyday sensitivity. Learn the symptoms, genetics, and diet levers that matter.

The BHMT gene encodes an enzyme that recycles homocysteine into methionine using betaine, providing a folate-independent backup to the MTHFR pathway. This article explains what BHMT does, how the rs3733890 variant fits into the methionine cycle, and the nutrients and pathways that keep homocysteine in balance.

Facial emotion recognition is a measurable skill shaped by genes and experience. Variants in OXTR (rs53576) and COMT (Val158Met) influence empathy and emotion processing, but practice can sharpen it. Learn the science and how pathway-level genetic insight adds context.

Dairy sensitivity is largely genetic: the MCM6 variant rs4988235 controls whether the LCT gene keeps producing lactase into adulthood, determining lactose intolerance risk. Learn how lactase persistence varies by ancestry, how lactose intolerance differs from milk allergy, and how to manage dairy with your provider.

About 3 in 10 cannabis users develop some degree of cannabis use disorder, and twin studies estimate genetics accounts for 50-70% of vulnerability. This article explains the role of CNR1, FAAH, AKT1, and CHRNA2 variants in the endocannabinoid and reward pathways, and why genetics is context rather than a prediction.

The IL23R gene controls the IL-23/IL-17 immune axis, and its variants shift risk across inflammatory bowel disease, psoriasis, ankylosing spondylitis, and psoriatic arthritis. Learn how the rs11209026 (Arg381Gln) variant can be protective and how genetics adds pathway-level context to autoimmune risk.

Dandruff comes from Malassezia yeast, scalp oil, and individual sensitivity shaped by genetics. Skin barrier variants in the FLG gene and inherited immune tone influence who flakes. Learn the genetic factors and evidence-based management, plus how pathway-level insight adds context.

Bifidobacterium longum is a keystone gut bacterium that ferments fiber into short-chain fatty acids, supports the gut barrier, and helps train immunity. Levels are shaped by diet and by genes like FUT2 (secretor status). Learn what boosts it and where genetic context fits.

Air pollution sensitivity is partly genetic: detox genes like GSTM1 and GSTP1 (Ile105Val) and antioxidant genes such as NQO1 shape how your body clears airborne toxins. This article explains the biology, the GSTM1-null genotype, and how pathway-level genetic insight adds context to your exposure risk.

Deep vein thrombosis risk is shaped by inherited clotting differences. Factor V Leiden in the F5 gene is the most common, followed by prothrombin G20210A in F2 and rarer deficiencies in antithrombin, protein C, and protein S. This article explains these thrombophilia variants and how they combine with triggers like surgery and immobility.

Sensation seeking has four components — thrill and adventure seeking, experience seeking, disinhibition, and boredom susceptibility — all tied to dopamine biology. Gene variants in DRD4 and COMT (Val158Met) influence novelty response and reward sensitivity. Learn what the science shows and how pathway-level genetic insight adds context to your biology.

The FOLH1 gene encodes folate hydrolase, the enzyme that lets your gut absorb dietary folate — the first step of folate metabolism. Learn how FOLH1 variants like rs61886492 affect folate status, how FOLH1 works in sequence with MTHFR, and how pathway-level genetic insight informs personalized nutrition.

Alkaline phosphatase (ALP) is a routine blood marker that reflects liver, bone, and genetic factors. Learn what high and low ALP can indicate, how the ALPL gene and hypophosphatasia set enzyme levels, and how common variants near ABO and GPLD1 — plus your blood type — shape your baseline reading.

The PTPN22 gene variant R620W (rs2476601) is one of the broadest autoimmune-associated variants, linked to type 1 diabetes, rheumatoid arthritis, lupus, and thyroid conditions. This article explains how one immune-brake gene touches so many diseases, what a result means, and what genetic insight adds.

Roughly half of people with diabetes develop neuropathy, but not everyone with similar blood sugar does. This article explains how genetic variants in AKR1B1, GPX1, ACE, and MTHFR shape nerve-damage susceptibility, why blood-sugar control still comes first, and what pathway-level genetic insight adds to a provider-led plan.

Rectal prolapse is when the rectum slips through the anus, causing a bulge, mucus, bleeding, or incontinence. Causes include chronic straining, childbirth, aging, and connective-tissue genetics like COL3A1. Learn the symptoms, risk factors, and when to see a qualified provider.

Recurrent bronchitis is rarely random. Variants in genes such as SERPINA1 (alpha-1 antitrypsin) and GSTM1 shape lung protection and antioxidant defense, while smoking and pollution multiply the risk. Learn how genetic pathway insight fits alongside a provider conversation.

Genetic factors in dry eye involve tear-film genes like AQP5 and MUC5AC, autoimmune-linked HLA class II genes, and inflammatory pathways such as TNF and IL6. This article reviews what the research shows about the genetics of dry eye and how a pathway-level genetic test fits alongside professional eye care.

The RGS2 gene codes for regulator of G protein signaling 2, a molecular brake on brain-cell signaling. Its rs4606 variant has been linked to reduced RGS2 expression and higher anxiety and stress sensitivity. This article explains the mechanism, the research, and what pathway-level genetic insight reveals.