Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

Deep Vein Thrombosis: The Genetic Basis

The genetic makeup of individuals explains why some people develop blood clots more frequently than others. The answer may lie in their genetics. Deep Vein Thrombosis (DVT) occurs when blood clots develop in deep leg veins and exploring its genetic basis helps identify useful prevention and treatment methods.

Genetic Description of DVT

Genetic factors determine approximately 60% of the variation in the risk of developing Deep Vein Thrombosis (DVT) between individuals. Genetic research has revealed that specific blood clotting genes act as major contributors to the development of DVT in people. People who have genetic conditions resulting in high EPA levels face greater risks of venous thromboembolism compared to individuals who possess high alpha-linolenic acid levels and have reduced risks of DVT. The development of DVT is influenced by genetic predispositions as well as various risk factors like age over 60 years old and a sedentary lifestyle and deep vein injuries or surgeries combined with pregnancy and hormone therapy intake or birth control pill usage along with obesity and smoking habits. Patients who have cancer, heart failure or inflammatory bowel disease face increased risks of developing DVT.

Practical Advice for Managing DVT Risk

  1. Stay Active: Physical exercise helps maintain proper blood circulation which prevents the formation of blood clots. Daily exercise routines help maintain healthy blood circulation.
  2. Maintain a Healthy Weight: Obesity stands as a recognized risk factor for developing deep vein thrombosis. Regular exercise combined with a balanced diet helps control body weight which reduces your chances of forming blood clots.
  3. Avoid Prolonged Immobility: People who sit most of the day or who are healing after surgery should make consistent movement part of their schedule to stop blood from stagnating in their veins.
  4. Quit Smoking: Tobacco use harms blood vessels while raising the risk of clot formation in the bloodstream. Better vascular health requires quitting smoking through available support programs.
  5. Follow a Balanced Diet: A diet high in omega-3 fatty acids from sources like fish and walnuts helps prevent inflammation and reduces the chance of developing blood clots.

Conclusion

Knowledge of genetic influences on Deep Vein Thrombosis helps identify people who face higher risks and enables the implementation of preventive strategies. Implementing lifestyle changes alongside managing modifiable risk factors helps people lower their DVT risk and improve vascular health. Begin protecting your health proactively while investigating PlexusDx's Precision Health & Wellness tests for customized genetic insight. Maintain awareness of health information and take active steps to keep your health as a top priority. The Precision Health & Wellness tests from PlexusDx can be purchased through their official website PlexusDx.com as well as on Amazon and Walmart.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.

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