PlexusDx vs Willow: Semaglutide and Tirzepatide Plans Compared

Last reviewed: September 4, 2026 Last updated: September 4, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

PlexusDx charges $189 per month for compounded semaglutide injection and $289 per month for compounded tirzepatide injection on a month-to-month basis, while Willow charges $299 per month for semaglutide and $399 per month for tirzepatide injection. Over 12 months, PlexusDx costs $1,320 less per year for either medication on month-to-month plans. Both programs include the provider visit, prescription, medication, and shipping in a single monthly price with no separate membership fees. PlexusDx offers multi-month prepaid options that reduce the per-month cost further, while Willow operates on monthly billing only. Oral formulations are available from both providers; Willow's oral pricing was not itemized in public sources as of September 4, 2026, so this comparison focuses on injection routes where verified pricing exists for both programs.

At-a-glance comparison

PlexusDx pricing verified September 4, 2026; Willow pricing verified September 4, 2026. MTM = month-to-month.

Normalized pricing: 12-month cost comparison

The most direct comparison uses each program's month-to-month rate with no prepayment required. Over 12 months, the total cost difference is identical for both medications.

Semaglutide injection

Willow: $299/month × 12 = $3,588 per year (verified September 4, 2026)
PlexusDx (month-to-month): $189/month × 12 = $2,268 per year
Difference: Willow costs $1,320 more per year (our calculation)

Tirzepatide injection

Willow: $399/month × 12 = $4,788 per year (verified September 4, 2026)
PlexusDx (month-to-month): $289/month × 12 = $3,468 per year
Difference: Willow costs $1,320 more per year (our calculation)

PlexusDx prepaid plans (for reference)

PlexusDx offers 3-month and 6-month prepaid plans that reduce the effective per-month rate. These figures are our calculation of the prepaid per-month equivalent.

Semaglutide injection, 6-month prepaid: $149/month × 12 = $1,788 per year (our calculation)
Willow costs $1,800 more per year vs. this prepaid option (our calculation)

Tirzepatide injection, 6-month prepaid: $249/month × 12 = $2,988 per year (our calculation)
Willow costs $1,800 more per year vs. this prepaid option (our calculation)

Willow operates on monthly billing only; no multi-month prepaid plans were documented in public sources as of September 4, 2026.

Decision factors: strengths and gaps

Price transparency and verified figures

Both PlexusDx and Willow publish single all-inclusive monthly rates. PlexusDx pricing was verified September 4, 2026, across all products and plan lengths. Willow pricing for semaglutide ($299/month) and tirzepatide injection ($399/month) was verified the same day via public pricing pages. Willow's oral route pricing was not itemized in public sources as of that date, so readers considering oral formulations should confirm pricing at checkout.

Plan flexibility and commitment

Willow charges a single monthly rate with monthly billing and no documented prepayment requirement. PlexusDx offers three plan lengths: month-to-month, 3-month prepaid, and 6-month prepaid, with progressively lower per-month rates on longer commitments. The month-to-month plan carries no prepayment or upfront cost beyond the first month.

Inclusions and fees

Both programs include the provider visit, prescription, medication, and shipping in the stated monthly price. Neither charges a separate membership or service fee. Willow advertises free 2-day shipping. Both programs accept HSA/FSA payment.

Medication options and dose adjustments

PlexusDx publishes the same per-month price at every dose for a given medication and route; dose adjustments do not change the monthly cost. Willow's dose-pricing structure was not itemized in public sources. Both programs offer compounded semaglutide and tirzepatide in injection and oral routes, though Willow's oral pricing remains unverified.

Regulatory status

Both programs dispense compounded medications prepared by licensed pharmacies. Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Choose Willow if…

Willow may suit readers who prefer a provider with a straightforward monthly billing model and advertised 2-day shipping, and who are comfortable with a higher per-month cost in exchange for that simplicity. Willow's pricing was verified for injection routes; readers interested in oral formulations should confirm pricing directly with Willow before enrolling, as that figure was not itemized in public sources as of September 4, 2026.

Choose PlexusDx if…

PlexusDx offers the lowest documented per-month cost for both semaglutide and tirzepatide injection among the two programs compared here. The month-to-month plan saves $110 per month on semaglutide and $110 per month on tirzepatide vs. Willow's corresponding rates, with no prepayment required. Readers who value plan flexibility can start month-to-month and switch to a prepaid plan later, or choose a 6-month plan from the start to reach the lowest effective per-month rate ($149 for semaglutide injection, $249 for tirzepatide injection). PlexusDx also publishes verified pricing for oral semaglutide ($289/month month-to-month) and oral tirzepatide ($349/month month-to-month), and offers a microdose semaglutide injection protocol ($129/month) for maintenance phases. The same flat price applies at every dose within a given medication and route, so dose titration does not trigger a price increase.

Methodology and freshness

PlexusDx pricing was verified September 4, 2026, via the live product pages at plexusdx.com. Willow pricing for compounded semaglutide ($299/month) and compounded tirzepatide injection ($399/month) was verified September 4, 2026, via public pricing pages and marketing materials. Willow's oral route pricing was not itemized in public sources as of that date. All 12-month cost calculations are ours, derived by multiplying the stated per-month rate by 12. Prepaid per-month equivalents for PlexusDx 3-month and 6-month plans are our calculation of the effective monthly rate when the total prepaid amount is divided by the commitment length. No promotional codes, first-month discounts, or limited-time offers were identified for either program. Readers should confirm all pricing, plan terms, eligibility criteria, and medication availability at checkout, as rates and policies may change after publication.

Frequently Asked Questions

Does Willow charge less than PlexusDx for any medication or plan?

No. Among the verified pricing available as of September 4, 2026, Willow's month-to-month rates for semaglutide injection ($299) and tirzepatide injection ($399) are higher than PlexusDx's corresponding month-to-month rates ($189 and $289). Willow's oral formulation pricing was not itemized in public sources, so no oral-route comparison is possible with verified figures.

Can I switch from month-to-month to a prepaid plan later?

PlexusDx allows plan changes; a reader starting on the month-to-month option can later choose a 3-month or 6-month prepaid plan to reduce the per-month cost. Willow operates on monthly billing; no multi-month prepaid structure was documented in public sources as of September 4, 2026. Confirm any plan-change policies directly with the provider before enrolling.

Are these programs covered by insurance?

Neither program bills insurance directly. Both PlexusDx and Willow accept HSA and FSA payment, which allows use of pre-tax health savings for eligible expenses. Some patients seek reimbursement by submitting receipts to their insurer, but coverage and reimbursement policies vary widely. Confirm your plan's policies before assuming any reimbursement.

What is the difference between compounded semaglutide and branded Wegovy or Ozempic?

Compounded medications are not FDA-approved and are not reviewed by FDA for safety, effectiveness, or quality before marketing. Branded Wegovy and Ozempic contain FDA-approved semaglutide manufactured by Novo Nordisk. A licensed clinician determines whether a compounded or branded prescription is appropriate for an individual patient. Compounded formulations are typically less expensive than branded drugs.

How quickly will I receive my first shipment?

Willow advertises free 2-day shipping. PlexusDx includes shipping in the monthly price; typical delivery timeframes were not itemized in the sources reviewed here. After a provider approves a prescription, the compounding pharmacy prepares and ships the medication. Confirm expected delivery windows with the provider during intake or onboarding.

Sources

• PlexusDx product pages (plexusdx.com), accessed September 4, 2026
• Willow public pricing pages, accessed September 4, 2026
• Willow marketing materials and checkout flow, accessed September 4, 2026

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. A licensed clinician determines whether a prescription is appropriate for an individual patient. PlexusDx works with licensed 503A compounding pharmacies.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.