MEDVi Tirzepatide Cost: Intro Pricing vs Refill Rates Compared

Last reviewed: September 12, 2026 Last updated: September 12, 2026

Written by: Jay Hastings, CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx publishes this comparison and is one of the providers discussed. We use the same evidence rules for our own program and competing programs.

The short answer

MEDVi's compounded tirzepatide costs $279 for the first month (introductory), then $399 per month for refills—medication, clinician care, unlimited support, and shipping all included, no membership fee, cancel anytime (medvi.com, captured September 4, 2026). That first-month discount brings the 12-month total to $4,668, or an effective $389 per month average over the year (our calculation). PlexusDx tirzepatide injection runs $289 per month flat month-to-month, $269 per month prepaid on a 3-month commitment, or $249 per month prepaid on a 6-month commitment—$3,468, $3,228, or $2,988 for 12 months respectively—with the same clinician oversight, medication, and shipping, plus a free PharmD check-in (plexusdx.com, captured September 12, 2026). At ongoing rates, PlexusDx month-to-month saves $1,320 per year versus MEDVi's refill price (our calculation).

At-a-glance: MEDVi vs PlexusDx tirzepatide

MEDVi tirzepatide pricing breakdown

MEDVi advertises compounded tirzepatide—both injectable and oral formulations—at $279 for the first month (introductory rate), then $399 per month for all subsequent refills (medvi.com, captured September 4, 2026). The introductory price applies once; every refill thereafter carries the $399 rate. Both figures are all-inclusive: medication, clinician consultation, unlimited support messaging, and shipping. MEDVi charges no membership fee on its compounded pathway and offers cancel-anytime terms (medvi.com, captured September 4, 2026).

Dose titrations follow clinician protocol and do not raise the monthly price; whether you remain on a starting dose or escalate to a higher dose, the refill rate stays $399 (medvi.com, captured September 4, 2026).

MEDVi also advertises 3-, 6-, and 12-month prepaid bundles with 0% financing (medvi.com, captured September 12, 2026), but specific bundle rates were not published in our research capture, so we are not publishing MEDVi's bundle rates and instead focus on the verified month-to-month first-month and refill figures.

MEDVi shows final pricing after completion of its health questionnaire (medvi.com, captured September 12, 2026).

PlexusDx tirzepatide pricing breakdown

PlexusDx publishes three tiered pricing levels for compounded tirzepatide injection, all visible before intake (plexusdx.com, captured September 12, 2026):

• Month-to-month: $289 per month
• 3-month commitment: $269 per month (prepaid quarterly; our calculation of the per-month equivalent)
• 6-month commitment: $249 per month (prepaid biannually; our calculation of the per-month equivalent)

PlexusDx also offers compounded tirzepatide in oral-capsule form at $349 month-to-month, $299 per month on a 3-month commitment, or $279 per month on a 6-month commitment (PlexusDx internal pricing schema).

Every tier holds the same price regardless of dose: whether you are prescribed 2.5 mg weekly or titrate to 10 mg or higher, the monthly cost remains fixed (plexusdx.com, captured September 12, 2026). Each plan includes the online clinician visit, prescription, compounded medication, and shipping. PlexusDx charges no membership fee and includes a free check-in with a Doctor of Pharmacy; an optional genetic test is available for $298 (or $99 for active members) (plexusdx.com, captured September 12, 2026).

Normalized 12-month cost comparison

To see total cost over a year—accounting for MEDVi's introductory discount and PlexusDx's commitment tiers—we calculate 12-month totals using only the figures each company has published or verified at checkout. All derived totals and per-month averages below are our calculations.

MEDVi tirzepatide (month-to-month with first-month discount)

• Month 1 (introductory): $279
• Months 2–12 (refill rate): 11 × $399 = $4,389
• 12-month total: $279 + $4,389 = $4,668
• Effective monthly average: $4,668 ÷ 12 = $389/month

PlexusDx tirzepatide injection

• Month-to-month: 12 × $289 = $3,468
• 3-month commitment (prepaid quarterly): 12 × $269 = $3,228
• 6-month commitment (prepaid biannually): 12 × $249 = $2,988

Side-by-side annual comparison (MEDVi vs PlexusDx injection MTM, ongoing rates)

• MEDVi ongoing (ignoring first-month discount): 12 × $399 = $4,788
• PlexusDx month-to-month: $3,468
• Difference: $4,788 − $3,468 = $1,320 annual savings with PlexusDx
• Per-month difference: $399 − $289 = $110/month

Even with MEDVi's $279 first month factored in ($4,668 total), PlexusDx month-to-month remains $1,200 less expensive over 12 months; the 6-month commitment widens the gap to $1,680 annually (our calculations).

What each program includes

MEDVi inclusions and support

MEDVi's $279 first-month and $399 refill rates bundle medication, clinician care and consultation, unlimited messaging support, and shipping (medvi.com, captured September 4, 2026). The program adds a free care-coaching service, a free visit with a registered dietitian, and unlimited doctor calls at no extra charge (medvi.com, captured September 12, 2026). Compounded-pathway members pay no membership fee; MEDVi's $99/month membership applies only to its branded Wegovy/Zepbound pathway, which carries separate medication costs (medvi.com, captured September 4, 2026).

PlexusDx inclusions and support

PlexusDx tirzepatide pricing is all-inclusive: the online provider visit, prescription, compounded medication, and USPS Priority shipping are covered in the $289/$269/$249 monthly rate (plexusdx.com, captured September 12, 2026). Every member receives a free check-in with a Doctor of Pharmacy to review dosing, side effects, and medication interactions. An optional genetic panel ($298 standalone, $99 for active members) analyzes genetic variants that influence GLP-1 response and can inform dose or adjunct therapy decisions (plexusdx.com, captured September 12, 2026).

Strengths and decision factors

MEDVi strengths

• Multimodal support built in: Free dietitian visit, care coaching, and unlimited doctor calls extend beyond typical prescription-fulfillment models.
• Introductory discount: The $279 first month lowers initial cost for members who want to trial tirzepatide before committing to the refill rate.
• Oral and injectable routes advertised: Both formulations carry the same pricing structure, offering route flexibility without surcharge at the tirzepatide tier (medvi.com, captured September 4, 2026).
• Established review base: 4.3 stars across approximately 15,000 Trustpilot reviews signals operational scale and generally positive member experience (trustpilot.com, captured September 4, 2026).

MEDVi gaps

• Higher ongoing cost: At $399 per refill, MEDVi runs $110 per month above PlexusDx month-to-month—$1,320 annually on an ongoing basis (our calculation).
• Pricing shown after questionnaire: Final rates appear only after health-history submission, whereas PlexusDx publishes every tier before intake (medvi.com and plexusdx.com, captured September 12, 2026).
• Bundle rates not published: MEDVi advertises prepaid 3-, 6-, and 12-month options with 0% financing but does not display bundle pricing on its public pages; members must complete the intake to see those rates (medvi.com, captured September 12, 2026).

PlexusDx strengths

• Lower baseline cost: $289 month-to-month is $110 below MEDVi's $399 refill rate; the 6-month tier ($249/month) saves $1,680 annually versus MEDVi ongoing (our calculation).
• Transparent pricing before intake: All tiers, all doses, published on the product page with no questionnaire gate (plexusdx.com, captured September 12, 2026).
• Pharmacist consult included: A free Doctor of Pharmacy check-in adds clinical oversight and medication-safety review at no extra charge.
• Optional genetics: Genetic testing can identify responders, guide dose, and flag drug-interaction risk—a decision-support layer not offered by MEDVi.

PlexusDx gaps

• Narrower support bundle: PlexusDx does not include dietitian visits or dedicated care coaching in its base price; members seeking structured nutrition counseling may need to arrange that separately.

Choose MEDVi if…

• You value bundled behavioral support—dietitian visits, care coaching, and unlimited doctor calls—and are willing to pay a premium for that integrated service layer.
• You want to start at a lower first-month cost ($279) before committing to the $399 refill rate.
• You prefer a program with a deep Trustpilot review history and established telehealth brand recognition.
• You are interested in MEDVi's branded Wegovy/Zepbound pathway and want one platform for both compounded and FDA-approved options.

Choose PlexusDx if…

• You want the lowest ongoing tirzepatide cost: $289 month-to-month saves $1,320 annually versus MEDVi's $399 refill rate, and the 6-month tier ($249/month) saves $1,680 per year (our calculations).
• You prefer transparent pricing published before intake—no questionnaire required to see every tier and dose price.
• You value pharmacist-level medication review: a free Doctor of Pharmacy check-in can catch drug interactions, adjust dosing for side effects, and answer compound-formulation questions.
• You are considering genetic testing to personalize GLP-1 therapy and want that option available in the same workflow.
• You want flexibility to start month-to-month or lock a lower rate with a 3- or 6-month prepaid commitment.

Extra fees, dose increases, and cancellation

Both MEDVi and PlexusDx include medication, clinician consultation, and shipping in their published monthly rates; neither charges a membership fee on the compounded pathway (medvi.com and plexusdx.com, captured September 4 and September 12, 2026). Both programs hold the monthly price constant as dose increases: whether you remain on 2.5 mg weekly or escalate to 10 mg or 15 mg, the rate does not change (medvi.com and plexusdx.com, captured September 4 and September 12, 2026).

MEDVi operates on a monthly-refill model with no contract; members may cancel anytime (medvi.com, captured September 4, 2026). PlexusDx month-to-month subscriptions carry the same cancel-anytime terms; the 3-month and 6-month tiers are prepaid commitments—members pay the full period upfront and receive shipments at the clinician-determined interval within that window (plexusdx.com, captured September 12, 2026).

MEDVi's optional services—care coaching, dietitian visit, unlimited doctor calls—are included at no extra charge in the base tirzepatide price (medvi.com, captured September 12, 2026). PlexusDx includes a free PharmD check-in; the genetic panel is optional and priced separately ($298 or $99 for active members) (plexusdx.com, captured September 12, 2026).

Oral vs injectable route pricing

MEDVi advertises compounded tirzepatide in both oral and injectable forms at the same $279 first-month / $399 refill rate; no oral surcharge appears in the published pricing grid (medvi.com, captured September 4, 2026). For context, MEDVi's semaglutide tablet formulation adds $70 per month to the injection price—$249 first month and $369 refill versus $179/$299 for injection—but that differential is not applied to tirzepatide in the advertised rate card (medvi.com, captured September 4, 2026).

PlexusDx prices oral tirzepatide capsules at $349 month-to-month, $299 per month on a 3-month commitment, or $279 per month on a 6-month commitment—each tier $60 above the corresponding injectable plan (PlexusDx internal pricing schema). Oral and injectable tirzepatide are distinct products on the PlexusDx platform, and route selection happens during intake; a licensed clinician determines which formulation is appropriate based on the member's health profile and preference.

Review and reliability snapshot

MEDVi holds a 4.3-star rating on Trustpilot across approximately 15,000 reviews (trustpilot.com, captured September 4, 2026). No negative themes were coded in our review-pass research, indicating broad member satisfaction at scale. PlexusDx holds a 4.3-star rating on Trustpilot, with 79% of reviews at five stars and 83% at four stars or higher (trustpilot.com/review/plexusdx.com, captured September 9, 2026). Both programs demonstrate established operations and generally positive member feedback; neither shows red-flag patterns in publicly visible reviews at the time of capture.

Methodology and freshness

We captured MEDVi's tirzepatide pricing—$279 first month (introductory), $399 refill—from medvi.com on September 4, 2026, and verified those figures at checkout. MEDVi's bundle availability (3-, 6-, 12-month with 0% financing) was noted on September 12, 2026, but specific bundle rates were not published, so we do not report them. PlexusDx tirzepatide injection pricing ($289 month-to-month, $269 3-month, $249 6-month) was captured from plexusdx.com on September 12, 2026; oral capsule pricing is drawn from PlexusDx's internal schema. All 12-month totals, effective monthly averages, and annual savings figures are our calculations, derived by multiplying published monthly rates by 12 or by summing the first-month introductory price with eleven refill charges. We label every derived figure as "our calculation" to distinguish it from company-published rates. Trustpilot ratings for MEDVi (September 4, 2026) and PlexusDx (September 9, 2026) are reported with platform and capture date. Price-verification dates appear in the at-a-glance table. Readers should confirm current pricing, eligibility, and product availability at checkout; telehealth programs may update rates, pause compounded formulations during shortages, or adjust terms at any time.

Frequently Asked Questions

Does MEDVi's $279 tirzepatide price apply every month?

No. The $279 figure is an introductory first-month rate; every refill thereafter costs $399 per month (medvi.com, captured September 4, 2026). Over 12 months the total is $4,668, or an effective $389 per month average (our calculation).

How much cheaper is PlexusDx tirzepatide than MEDVi on an ongoing basis?

PlexusDx month-to-month tirzepatide injection is $289 versus MEDVi's $399 refill rate—a $110 per month or $1,320 annual difference (our calculation). PlexusDx's 6-month tier ($249/month) saves $1,680 per year versus MEDVi ongoing (our calculation).

Do either program's prices increase when I titrate to a higher dose?

No. Both MEDVi and PlexusDx hold the monthly price constant regardless of dose. Whether you remain on a starting dose or escalate under clinician guidance, the rate stays the same (medvi.com and plexusdx.com, captured September 4 and September 12, 2026).

What support services are included in each program's base price?

MEDVi includes free care coaching, a free dietitian visit, and unlimited doctor calls in its $279/$399 tirzepatide pricing (medvi.com, captured September 12, 2026). PlexusDx includes a free check-in with a Doctor of Pharmacy; optional genetic testing costs extra ($298 or $99 for members) (plexusdx.com, captured September 12, 2026).

Can I see pricing before filling out a health questionnaire?

PlexusDx publishes every tier—month-to-month, 3-month, 6-month—on its product pages before intake (plexusdx.com, captured September 12, 2026). MEDVi shows final pricing after you complete its health questionnaire (medvi.com, captured September 12, 2026).

Sources

• MEDVi tirzepatide pricing and inclusions – medvi.com (accessed September 4, 2026 and September 12, 2026)
• PlexusDx tirzepatide injection pricing and inclusions – plexusdx.com (accessed September 12, 2026)
• PlexusDx oral tirzepatide pricing – PlexusDx internal pricing schema
• MEDVi Trustpilot rating – trustpilot.com (accessed September 4, 2026)
• PlexusDx Trustpilot rating – trustpilot.com/review/plexusdx.com (accessed September 9, 2026)

Compounded medication disclosure: Compounded medications are not FDA-approved. FDA does not review compounded drugs before marketing for safety, effectiveness, or quality. PlexusDx works with licensed 503A compounding pharmacies. A licensed clinician determines whether a prescription is appropriate for an individual patient.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.