Last reviewed: May 12, 2026
Last updated: May 12, 2026
Written by:
Jay Hastings
,
CEO of PlexusDx
Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.
Medically reviewed by:
Jayden Lee, PharmD, EMBA
Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.
This article is part of the PlexusDx Education Hub, your resource for evidence-based guidance on GLP-1 therapies, weight-management protocols, and the genetics behind them. Browse all Peptides & GLP-1 education
This is an independent editorial review. PlexusDx has no commercial relationship with Hers, and no affiliate compensation influences this look at its weight-management program.
A weight-management program is more than a prescription; it is a medication choice wrapped in a service model. This review looks at how Hers approaches weight management, the medications it can involve, and the provider and pharmacy structure behind them, before turning to the genetic groundwork any protocol sits on. Editorial balance, not a buying recommendation. As of April 2026.
Start your GLP-1 program with PlexusDx
One all-inclusive price covers your online provider visit, prescription, compounded medication, and shipping — no membership, no hidden fees. Complete a short intake and a licensed provider takes it from there.
Start your intake →
How Hers approaches weight management
Hers (Hims & Hers Health) frames weight management as an ongoing, clinically supervised telehealth service rather than a one-off purchase. A prospective patient is evaluated by a licensed provider, and, where appropriate, enters a medication-supported plan with continued follow-up. The emphasis is on a supervised program structure, which is what separates this approach from simply obtaining a drug.
Medication options within the program
The medications relevant here are the incretin agonists: GLP-1 receptor agonists such as semaglutide, and the GIP/GLP-1 dual agonist tirzepatide. Depending on eligibility and route, these can arrive as FDA-approved branded products from a retail pharmacy or as compounded preparations from a 503A pharmacy, the latter not being FDA-approved products themselves. The specific options a program supports are set by the brand and listed on Hers's official website.
The provider and pharmacy model
The workflow typically runs from an online intake covering weight, medical history, and medications, to a licensed clinician's review and prescription, to fulfillment by a retail or compounding pharmacy, to follow-up visits supporting titration and side-effect management. Provider type and pharmacy partner vary by case. Program pricing appears on the brand's own site; across the market, monthly totals as of April 2026 run roughly $200 to $700+, with wide variance.
Evidence behind GLP-1 weight programs
The clinical backing for this category comes chiefly from STEP (semaglutide; The New England Journal of Medicine, 2021), SURMOUNT (tirzepatide; NEJM, 2022), and SURMOUNT-OSA (tirzepatide in obstructive sleep apnea; NEJM, 2024). Because these programs used different endpoints and populations, their results describe group averages, and individual outcomes vary.
The genetic layer these programs leave out
A weight-management protocol does not account for the upstream genetic architecture that shapes how any GLP-1 compound behaves in a given body. Variants in FTO, the fat-mass and obesity-associated gene, along with GLP1R (the GLP-1 receptor gene that every GLP-1 compound targets), MC4R (a melanocortin receptor tied to satiety and energy balance), and TCF7L2 (a transcription factor linked to glucose homeostasis) describe the metabolic terrain a clinician is prescribing into. These are pathway-level signals. They do not predict response to any specific medication, but they map the biology beneath the decision, context a telehealth prescription on its own never captures.
PlexusDx provides semaglutide and tirzepatide through its Weight Management Protocols, available as Semaglutide Injection, Semaglutide Oral, Tirzepatide Injection, and Tirzepatide Oral. What distinguishes the approach is that upstream genetic context. Before starting any GLP-1 pathway protocol, the Precision Peptide Genetic Test analyzes 14 pathways, 49 peptides, 150+ genetic insights, including FTO, MC4R, and TCF7L2 variants that shape baseline appetite-regulation and energy-balance biology. Pairing that profile with the protocol is the test before you invest approach, turning guesswork into an informed conversation with your healthcare provider.
Not affiliated: PlexusDx is not affiliated with Hers and holds no commercial relationship with the companies discussed in this article.
Related reading on PlexusDx: GLP 1 Receptor Agonists For Weight Loss, GLP 1 Receptor Agonist For Weight Loss, Monjiro For Weight Loss, Rybelsus Weight Loss.
Disclaimer: This article is educational. PlexusDx is not affiliated with Hers and has no commercial relationship with the companies reviewed. PlexusDx offers semaglutide and tirzepatide through its own Weight Management Protocols, and this review compares approaches within the GLP-1 telehealth space. The Precision Peptide Genetic Test analyzes how your genes influence peptide-related biological pathways; it does not predict response to any specific medication. Consult a qualified healthcare provider before beginning any peptide protocol.
Compare the PlexusDx approach: explore the Weight Management Protocols for semaglutide and tirzepatide paired with the genetic context most telehealth programs omit. Or begin upstream and take the Precision Peptide Genetic Test to understand your GLP-1 pathway first.
Frequently Asked Questions
What medications does the Hers weight program use?
The relevant medications are incretin agonists: GLP-1 receptor agonists such as semaglutide and the dual GIP/GLP-1 agonist tirzepatide. Depending on eligibility and route, these arrive as FDA-approved branded products or as compounded preparations from 503A pharmacies, with options defined by the brand.
How is the Hers weight program structured?
It runs as a supervised telehealth service: an online intake, a licensed clinician's review and prescription, fulfillment by a retail or compounding pharmacy, and ongoing follow-up. The emphasis on continued supervision is what separates a program from simply obtaining a medication on its own.
Where does genetics fit into a weight protocol?
Before starting any protocol, the Precision Peptide Genetic Test analyzes pathway-level variants in FTO and MC4R, and TCF7L2 that describe baseline appetite and energy-balance biology. It does not predict drug response; it provides upstream context to inform a decision made with your healthcare provider.
This article is part of the PlexusDx Education Hub. Browse all Peptides & GLP-1 education
Medical and Editorial Standards
Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.
Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.
Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.
Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.
Share:
Zepbound vs Rybelsus: Injection vs Oral GLP-1 Compared
Hims Weight Loss Program: Eligibility, Medication Options, Pricing