The Impact of HLA-DQA2 Gene Variants on Alopecia Areata Risk

The HLA-DQA2 gene which associates with immune response functions critically to elevate the risk of developing alopecia areata which manifests as patchy hair loss. The major histocompatibility complex (MHC) protein encoding human genes within the human leukocyte antigen (HLA) system contain the HLA-DQA2 gene which produces a protein that activates the immune response to foreign substances. Alopecia areata appears significantly influenced by genetic changes in the HLA-DQA2 gene. Research with 4,332 participants found the 'G' variant of rs9275572 increases alopecia areata risk by up to 5 times. The same variant shows an elevated risk for HBV-related liver cancer as well as systemic lupus erythematosus and lung cancer. The 'G' variant of rs9275572 protects against HCV-induced liver cancer through different liver cancer-related pathways. A study comprising 10,796 participants revealed that the 'C' allele at rs9275524 is associated with about double the risk of developing alopecia areata. These two genetic variants commonly inherit together and function collectively as one genetic factor. People tend to have a complete set of either both problem genotypes or none at all. People who want to understand the effects of HLA-DQA2 gene variants on hair growth disorders such as alopecia areata can seek Precision Health & Wellness tests from PlexusDx. The tests provide in-depth analysis from genetic data which helps users understand their genetic susceptibility to diseases and potential health risks. The study of HLA-DQA2 gene functions in immune responses and its effect on alopecia areata can lead to important advances in personalized health care management. Through the use of genetic testing services such as PlexusDx people can actively work towards enhancing their health and wellness. The Precision Health & Wellness tests from PlexusDx help you discover important information about your genetic predispositions and health risks. For additional information visit PlexusDx.com or browse Amazon and Walmart.