Knowledge about our genetic predispositions delivers essential information about potential health risks and diseases we might develop.

The genetic trait DIO1 serves as an essential factor for thyroid hormone conversion. We will explore how the DIO1 gene affects thyroid function and why genetic variations of this gene can impact human health in this blog post.

The thyroid gland found at the front of the neck produces important hormones including T3 (triiodothyronine) and T4 (thyroxine). Hormones maintain vital bodily functions that affect heart function, energy production, bone growth and reproductive health. The DIO1 enzyme facilitates the transformation of T4 into its active form T3. The iodothyronine deiodinase enzyme encoded by the DIO1 gene plays a critical role in transforming T4 into T3. The DIO1 enzyme processes both T3 and T4 hormones through their breakdown. DIO1 operates best when it forms a complex with selenium and cysteine which classifies it as a selenoenzyme. Genetic differences in the DIO1 gene affect thyroid hormone functions and could lead to various health consequences.

Researchers found that the DIO1 gene variation rs2235544 correlates with diminished T3 hormone levels in the body. Individuals possessing the "A" allele at rs2235544 show decreased DIO1 expression compared to those who carry the "C" allele leading to diminished thyroid hormone activity. Patients who show low T3 levels might demonstrate hypothyroidism symptoms despite having normal or marginally increased T4 levels. A separate genetic variation named rs11206244 exists on the same gene but demonstrates weaker effects compared to rs2235544 SNP. The consideration of genetic variations and their effects on thyroid function and health is crucial.

Precision Health & Wellness tests from PlexusDx enable individuals to obtain important information about their genetic predispositions concerning thyroid function. Genetic testing services help individuals identify health risks which allows them to make knowledgeable healthcare choices together with professional medical support. The DIO1 gene is essential for thyroid hormone conversion while genetic differences within this gene can affect both thyroid function and general health. Individuals who learn about their genetic predispositions can implement effective health management strategies. PlexusDx Precision Health & Wellness tests allow you to learn about your genetic profile which helps you make educated choices regarding your health.