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This article investigates the intriguing aspects of the DAO gene and how it affects individual health. Examining genetic variants can reveal how they affect your body's histamine degradation process which might impact both digestive health and overall wellness. The AOC1 gene which encodes diamine oxidase (DAO) performs an essential function in the digestive system's histamine metabolism. Histamine functions as an essential body chemical through its role in immune defense activation and brain wakefulness signaling while helping to break down food during digestion. When DAO and similar enzymes fail to function properly they cannot degrade histamine which results in increased histamine levels that can trigger health problems. The body receives histamine through consumption of specific fish types and fermented products as well as processed meats and particular fruits and vegetables. The histamine concentration in food can change during cooking methods like frying and grilling which may worsen symptoms for people with histamine intolerance. Histamine intolerance displays through symptoms of bloating alongside abdominal pain digestive problems headaches skin reactions and respiratory difficulties. Four specific variants of the AOC1 gene including rs1049793, rs2052129, rs10156191 and rs1049742 correlate with decreased levels of the DAO enzyme and increased migraine occurrences. Reduced DAO activity occurs as a result of these genetic variants which prevent the body from breaking down histamine efficiently. The 'T' allele of rs2052129 shows protective properties against migraines in men yet reveals no significant impact in women despite most minor alleles being associated with decreased DAO function. The rs2268999 variant demonstrates a relationship with decreased DAO activity which shows the complex connection between genetic differences and health results. Research shows that specific genetic variants contribute to adverse reactions from non-steroidal anti-inflammatory drugs which highlights why understanding genetic predispositions is essential for personalized health care. Those who suffer from histamine intolerance or migraines can gain useful genetic information through PlexusDx testing which reveals their genetic predispositions. Knowledge about AOC1 gene variations helps individuals decide their dietary plans and lifestyle choices while identifying suitable treatment options. The study of the DAO gene reveals exciting connections between genetic mechanisms and health outcomes through its involvement in histamine metabolism. Accessing PlexusDx's Precision Health & Wellness test results empowers individuals to actively improve their health status. PlexusDx delivers personalized health reports at PlexusDx.com and through Amazon and Walmart to help you understand your genetic makeup and take control of your health journey.