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Low Lectin Diet

This intensive dietary intervention is designed to support inflammation management and autoimmunity by removing specific plant proteins that may trigger immune responses. Your Low Lectin Diet excludes high-lectin foods such as nightshade vegetables, grains, legumes, and squash, replacing them with nutrient-dense staples like cruciferous vegetables, wild fish, and leafy greens. To ensure broad compatibility with sensitive systems, this protocol is naturally dairy-free, gluten-free, grain-free, and nightshade-free, while focusing on low-glycemic and low-lectin ingredients. Your PlexusDx report provides insight into key inflammatory and immune genes such as CRP, TNF, and IL6, which regulate how your body responds to dietary triggers. By aligning your nutrition with these genetic pathways, this plan helps reduce systemic burden and supports your body’s natural ability to maintain balance.

The scientific framework for this diet centers on reducing intestinal permeability and modulating immune activity. High concentrations of lectins can potentially disrupt the gut barrier and digestion, while specific cooking methods are required to inactivate their biological effects. The following evidence-backed pillars form the foundation of your meal plan:

  • Gluten & Grain-Free: Since many cereal grains and legumes contain lectins, this program eliminates them entirely. Instead, it utilizes nutrient-dense alternatives like cauliflower, kale, and cabbage, which provide indoles (such as indole-3-Carbinol) to support immune function.
  • Fiber-Rich Strategy: This low-carbohydrate plan targets up to 30 grams of fiber daily through vegetables and nuts. Fiber supports the production of short-chain fatty acids, which may help reduce intestinal permeability and lower C-reactive protein (CRP) levels.
  • Cooked Food Focus: High temperatures are necessary to inactivate the antinutritional effects of lectins. Therefore, this program prioritizes cooked meals over raw preparations to minimize potential digestive disruptors.
  • Anti-Inflammatory Nutrients: The plan incorporates polyphenols from foods like walnuts, almonds, and spinach to help modulate inflammatory responses. It also emphasizes essential antioxidants, including Vitamin A from sweet potatoes and carrots, and Vitamin E from healthy oils and seeds, to reduce oxidative stress.

To customize your weekly menu using the PlexusDx meal planning tool, click the button below. If you need to adjust a suggestion to better fit your preferences or ingredient availability, you can easily use the "Swap" feature. Follow these steps to find the perfect alternative:

  1. Locate the meal you wish to change on your planner.
  2. Click the three dots in the corner of the recipe card.
  3. Select “Swap recipe” from the dropdown menu.
  4. Choose “Swap” to change just that single meal, or “Swap all” to replace it for the duration of the plan.
  5. Keep clicking “Swap” to cycle through compliant alternatives that match your specific plan rules, such as GF (gluten-free), DF (dairy-free), or egg-free options.

PlexusDx provides educational information about genetic predispositions only. This content is not medical advice. Always discuss genetic findings, test results, symptoms, and treatment decisions with your healthcare provider or an allergist to determine appropriate care for your situation.