GLP-1 Support Diet
The GLP-1 Support Diet is a specialized, nutrient-dense nutrition plan designed to work synergistically with GLP-1 medications or naturally support the body's blood sugar regulation systems. By prioritizing high-quality protein, healthy fats, and fiber while strictly adhering to a sugar-free, corn-free, and gluten-free framework, this low-glycemic protocol helps maintain lean muscle mass and stabilize energy levels during weight loss. This approach is particularly valuable for individuals with specific genetic variations found in their PlexusDx report, such as the TCF7L2 gene, which influences insulin secretion and GLP-1 signaling, or the FTO and MC4R genes, which play central roles in regulating appetite and satiety. By aligning your nutrition with these metabolic pathways, this plan aims to enhance health outcomes and mitigate common side effects associated with GLP-1 therapies.
This program is rooted in clinical evidence suggesting that specific dietary adjustments can significantly improve comfort and efficacy while on GLP-1 medications. The focus is on ensuring nutrient density in a calorie-controlled environment to prevent muscle loss and deficiencies. Key recommendations include:
- Prioritize Lean Protein: Incorporate consistent servings of fish, poultry, legumes, and egg whites to preserve lean muscle mass and prevent weakness often associated with rapid weight loss.
- Focus on Healthy Fats: Utilize olive oil, nuts, and seeds to stimulate natural GLP-1 release and support brain health, while strictly avoiding processed, greasy foods that can trigger gastrointestinal distress.
- Choose Low Glycemic & High Fiber Foods: Emphasize whole grains, fruits, and vegetables that digest slowly to prevent blood sugar spikes and maintain steady energy throughout the day.
- Manage Side Effects via Diet: Omit common irritants such as chocolate, mint, and spicy foods to protect the lower esophageal sphincter and reduce the risk of nausea or reflux.
- Ensure Nutrient Density: Select foods rich in calcium, magnesium, vitamin B12, and iron to counteract potential micronutrient gaps caused by reduced appetite and caloric intake.
To start utilizing this plan, click the button below to access your personalized PlexusDx meal planning tool. You can easily customize the menu to fit your specific preferences using our "Swap" feature. Simply follow these steps to find alternatives that match your needs:
- Locate the meal you wish to change on your planner.
- Click the three dots next to the meal name.
- Select “Swap recipe” from the dropdown menu.
- Choose “Swap” to change just that meal, or “Swap all” to replace it for the entire plan.
- Keep clicking “Swap” to cycle through approved alternatives that adhere to rules like gluten-free, corn-free, or specific nutrient targets.
PlexusDx provides educational information about genetic predispositions only. This content is not medical advice. Always discuss genetic findings, test results, symptoms, and treatment decisions with your healthcare provider or an allergist to determine appropriate care for your situation.

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GLP-1 Support Diet (Plant-Based)
GLP-1 Support Diet (Plant-Based)