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"I notice pretty immediate weight loss based on my changes. I feel much better — not just based on the weight loss but a noticeable reduction in inflammation. My body's ability to recover is better, and little aches and pains I usually would have are decreasing."

— Isayah | PlexusDx Functional Health Genetic Test | February 2026

Product: Functional Health Genetic Test  |  Health Focus: Metabolic Health & Weight Management  |  PlexusDx Customer Since: 2026

The Challenge

Isayah came to PlexusDx with curiosity more than crisis. He had a sense that his body operated in certain ways — some things he had noticed over time but never understood why, others he hadn't considered at all. He wanted a clearer picture of himself: what his genetics actually indicated about his metabolism, nutrient processing, and the low-level inflammation and aches he had accepted as normal. The Functional Health Genetic Test offered the kind of comprehensive, gene-level analysis he was looking for.

What the Test Revealed

The results confirmed some things Isayah had suspected and surfaced others he hadn't known. Critically, the test identified genetic issues with B-12 and K2 — two nutrients where his body's ability to process or utilize them was affected at the genetic level. The test also pointed toward carbohydrate metabolism as a meaningful factor in his metabolic health. These weren't vague tendencies — they were specific, actionable findings that gave him clear direction on where to focus his dietary and supplement adjustments.

What Changed

Isayah made targeted changes based directly on his results:

  • Shifted to a low-carbohydrate diet high in healthy fiber, aligned with his metabolic genetic profile
  • Added B-12 supplementation specifically formulated to address his identified genetic processing issue
  • Added K2 supplementation to address his identified K2 genetic variant

The Outcome

The results came quickly and came on multiple fronts. Isayah noticed weight loss relatively soon after implementing his changes — and the improvements didn't stop there. He also experienced a noticeable reduction in inflammation, faster physical recovery, and a decrease in the low-level aches and pains he had previously considered unavoidable. For Isayah, the experience was empowering: learning why his body behaved the way it did, and having the tools to actually do something about it. His description of the experience — "interesting and empowering" — captures what precision genetics can feel like when the findings are specific and the actions are clear.

In Their Own Words

"I found the information extremely interesting. I learned a lot about myself — some things I knew but didn't know why, other things I didn't know. I've switched to a more low-carb diet but high in healthy fibers. I've added a fairly specific vitamin supplementation protocol with specific vitamins like B-12 and K2, which I have genetic issues with. It has been an interesting and empowering experience to learn about myself. I notice pretty immediate weight loss based on my changes. I feel much better — not just based on the weight loss but a noticeable reduction in inflammation. My body's ability to recover is better, and little aches and pains I usually would have are decreasing."

— Isayah, PlexusDx Customer | February 2026

Results reflect Isayah's personal experience with PlexusDx genetic testing. Individual results will vary. PlexusDx genetic tests are not intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before making changes to your supplement or nutrition regimen.

Ready to find out what your genetics say about your metabolism, weight, and inflammation? Explore the Functional Health Genetic Test →

Frequently Asked Questions

What genetic factors can affect B12 and K2 processing?

Several genetic variants influence how the body absorbs, converts, and utilizes vitamin B12 and vitamin K2. For B12, variants in genes related to the methylation cycle — including MTHFR and related enzymes — can affect how efficiently your body converts B12 into its active forms, methylcobalamin and adenosylcobalamin. For K2, genetic variants in carboxylation pathways can affect how effectively K2 activates the proteins it's responsible for, including those related to calcium regulation and arterial health. Isayah's results identified specific genetic issues with both, pointing him toward supplementation forms and amounts that match his biology rather than general dosage guidance.

How can switching to a low-carb diet reduce inflammation based on genetic results?

Genetic variants that affect carbohydrate metabolism, insulin signaling, and inflammatory pathways can make some individuals significantly more responsive to dietary carbohydrate reduction than others. For people with these genetic tendencies, a high-carbohydrate diet may contribute to chronic low-grade inflammation, slower recovery, and metabolic inefficiency — even without producing dramatic symptoms. Isayah's experience — noticing reduced inflammation and faster recovery after shifting to a low-carb, high-fiber diet — reflects what can happen when a dietary change is not a generic recommendation but a genetics-informed one aligned with how his body actually processes food.

What does the PlexusDx Functional Health Genetic Test reveal about metabolism and weight management?

The Functional Health Genetic Test analyzes genetic variants across metabolic pathways including carbohydrate processing, fat metabolism, nutrient absorption, and inflammatory response. It identifies specific areas where your genetics may be contributing to metabolic inefficiency — and provides personalized dietary and supplement recommendations to address them. For customers like Isayah, the combination of a clear metabolic finding and a specific nutrient processing issue created an actionable protocol that produced observable results relatively quickly. Results are delivered through the PlexusDx Results Portal with specific guidance tailored to your full genetic profile.