PlexusDx DNA test kit with smartphone displaying genetic results on a white background
PlexusDx Longevity & Healthy Aging Genetic Test kit box with 150+ personalized aging and cellular health insights
Targeted DNA recommendations: personalized diet, supplement, and lifestyle insights based on your unique genetic results
How PlexusDx at-home DNA testing works: order online, swab at home, receive personalized genetic health reports
Your privacy is PlexusDx number one priority: HIPAA-compliant security, advanced encryption, data never sold or shared

Longevity & Healthy Aging Genetic Test

See how your genes shape aging, resilience, and long-term health, with guidance you can act on.

$298.00

One cheek swab, 228 DNA insights across longevity, heart, methylation, and healthy aging.

Four PlexusDx reports in one test: Longevity & Lifespan, Healthy Aging, Cardiometabolic, and Methylation Pathway.

Covers six areas, from cellular aging and telomeres to heart health, methylation, and how you age.

Genetic tendencies, not a diagnosis.

One test for life. Your DNA never changes.

Genetic Tests are a one-time purchase

Optional interest-free financing available. One-time purchase.

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Overview
228
genetic insights
4
genetic reports
140
genes
6
focus areas

The Longevity & Healthy Aging Genetic Test turns one cheek swab into 228 DNA insights across 140 genes, covering cellular aging and longevity, heart and metabolic health, methylation, inflammation, and how your skin, bones, and senses age.

Genes in this test
FOXO3SIRT1TERTPCSK9NOS3APOA5
Focus areas
Cellular aging & longevityHeart, cholesterol & blood pressureBlood sugar & metabolic healthMethylation & nutrient processingInflammation & immune agingSkin, bone & sensory aging
Reports included
Longevity & Lifespan Genetic ReportHealthy Aging Genetic ReportCardiometabolic Genetic ReportMethylation Pathway Genetic Report
HIPAA-compliant platform
Data never sold
One test for life
What you'll learn

What your DNA reveals in this test

Cellular aging & longevity

How your genes may relate to cellular aging, NAD and sirtuin activity, and the telomere pathways tied to a longer, healthier life. The well-studied FOXO3 and TERT genes sit here.

Heart, cholesterol & blood pressure

How your genes may shape heart and artery health, cholesterol and fat handling, and blood pressure as you age. Helpful context for cardiometabolic resilience.

Blood sugar & metabolic health

How your genes may shape blood sugar regulation, triglycerides, and the way your body turns food into energy.

Methylation & nutrient processing

How your genes may shape methylation, the everyday chemistry your body uses to process nutrients, balance neurotransmitters, and support detox. The well-known MTHFR gene sits here.

Inflammation & immune aging

How your genes may shape your inflammatory tendency and the way your immune system changes with age.

Skin, bone & sensory aging

How your genes may relate to skin aging and elasticity, bone and joint resilience, and how your vision, hearing, and other systems change over time. Context, not a diagnosis.

What this test covers

Your Longevity & Healthy Aging test looks at 228 genetic insights across 140 genes, grouped into six plain-language areas of longevity and healthy aging. Each one shows how your genes relate to a pathway, not a diagnosis.

Cellular aging & longevity

These genes are studied for how they relate to cellular aging, NAD and sirtuin activity, and the telomere pathways linked with a longer, healthier life.

Longevity and healthy agingNAD and sirtuin activityTelomere maintenanceCellular upkeep
Featured genesFOXO3SIRT1TERT

Heart, cholesterol & blood pressure

These genes relate to the health of your heart and arteries, how your body handles cholesterol and fats, and how it manages blood pressure as you age.

Heart and artery healthCholesterol and lipid handlingBlood pressure regulationClotting balance
Featured genesPCSK9NOS3APOA5

Blood sugar & metabolic health

These genes influence blood sugar regulation, triglyceride handling, and the broader way your body turns food into energy.

Blood sugar regulationMetabolic balanceTriglyceride and fat metabolism
Featured genesTCF7L2MTNR1BPPARG

Methylation & nutrient processing

These genes shape methylation, the everyday chemistry your body uses to process nutrients, balance neurotransmitters, and support detox. The well-known MTHFR gene sits here.

Folate and B-vitamin cycleMethionine and methyl donorsTranssulfuration and glutathioneNeurotransmitter and histamine processingCofactor nutrients
Featured genesMTHFRCOMTCBS

Inflammation & immune aging

These genes may shape your inflammatory tendency and the way your immune system changes with age.

Inflammatory tendencyImmune aging
Featured genesTNFNLRP3IL6

Skin, bone & sensory aging

These genes may relate to skin aging and elasticity, bone and joint resilience, and how your vision, hearing, and other systems change over time.

Skin aging and elasticitySun-related skin changesJoint comfortBone densityVision and eye healthHearing and balanceGum and oral healthBile and gallbladder healthEveryday energy
Featured genesMC1RVDRCFH

These insights describe tendencies your genes are associated with, not certainties about your health or how long you will live. They are a starting point for conversations with your provider, not a diagnosis.

How it works

From kit to results in four steps

1

Order your kit

We ship your DNA collection kit to your door for free, in discreet packaging.

2

Register and swab at home

Register your kit online with the included instructions, then take a quick, painless cheek swab. No needles, no clinic visit.

3

Mail it back

Seal your sample in the prepaid return envelope and drop it in the mail. Our CLIA-certified lab analyzes your DNA on the Illumina Global Screening Array.

4

Get your reports

In about 2 to 4 weeks, your reports and personalized guidance appear in your PlexusDx Results Portal.

Is this test right for you?
Who it's for
You want to understand how your genes may shape aging, longevity, and long-term health from one cheek swab.
You are curious about cellular aging, telomeres, NAD pathways, methylation, and cardiometabolic resilience.
You want personal nutrition, supplement, and lifestyle context built on your genetics, not generic anti-aging advice.
You want a DNA foundation to discuss with your provider and to pair with future blood tests.
You are starting with your DNA and want four healthy-aging reports covered in a single kit.
What it is not
A diagnostic test. It does not diagnose, treat, cure, or prevent any disease or condition.
A measure of your biological age or how long you will live. It reflects genetic tendencies only.
A promise of any specific health or longevity outcome. Your genes are one factor among many, including diet, activity, sleep, and environment.
The right starting point if you already have PlexusDx DNA on file. In that case, add the individual reports from your Results Portal instead.
What you receive

Everything included with your test

Four genetic reports

Your Longevity & Lifespan, Healthy Aging, Cardiometabolic, and Methylation Pathway reports, delivered together in your PlexusDx Results Portal.

An at-home swab kit

The cheek swab, collection vial, and a prepaid return envelope, with free shipping both ways.

Plain-English insights

Your results in clear language, with discussion points for you and your provider, not raw genetic data.

One swab, 228 insights

A single cheek swab covers all 228 insights across the four reports. Your DNA does not change, so you test once.

Your ecosystem

The reports inside this test

Each one is a full PlexusDx genetic report. Explore what they cover.

Longevity & Lifespan Genetic Report

How your genes may relate to cellular aging, NAD and sirtuin activity, telomere maintenance, and the pathways tied to a longer, healthier life.

View report

Healthy Aging Genetic Report

How your genes may shape the way your skin, bones, joints, senses, and energy tend to change as you age.

View report

Cardiometabolic Genetic Report

How your genes may relate to heart and artery health, blood pressure, blood sugar, triglycerides, and clotting balance.

View report

Methylation Pathway Genetic Report

How your genes may shape methylation, the everyday chemistry your body uses to process nutrients, balance neurotransmitters, and support detox.

View report

All your reports live in one place: your PlexusDx Results Portal, alongside any other PlexusDx tests and reports you own. One login, your whole genetic picture.

PlexusDx tests and reports are for wellness and educational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. Results are delivered through the PlexusDx Results Portal.

Built on your DNA

One cheek swab unlocks 228 DNA insights across longevity, heart health, and how you age.

$298

Order My Test

Free shipping both ways. One test for life.

Good to know

Frequently asked questions

Is this a diagnostic test?

No. This test is for education and wellness. It explains genetic tendencies linked to aging and does not diagnose disease, measure biological age, or predict how long you will live.

Do I need to retake this test later?

No. Your DNA does not change, so your results stay relevant for life.

Can this test be combined with blood testing?

Yes. Pairing genetic insights with blood biomarkers adds current-status context for deeper personalization.

How long does it take to get results?

Results are typically ready 2 to 4 weeks after the lab receives your sample.

What longevity-related genetic pathways does this test examine?

It looks at pathways tied to cellular aging and longevity, including NAD and sirtuin activity (SIRT1, SIRT3, SIRT6), telomere maintenance (TERT), and longevity-linked genes like FOXO3 and IGF1R. It also covers methylation and the MTHFR gene, heart and cholesterol pathways, inflammation, and how the skin, bones, and senses tend to age.