Does COMT Affect Estrogen Dominance? What the Genetics Show
Yes — COMT Val158Met directly shapes estrogen clearance speed, and slow COMT genotypes can contribute to the functional estrogen accumulation associated with estrogen dominance. The Precision Peptide Genetic Test analyzes COMT as part of 14 pathways, 49 peptides, and 150+ genetic insights — revealing your clearance baseline before symptoms or protocols make it relevant.
COMT Val158Met and Estrogen Clearance: What Your Genetics Reveal
The Precision Peptide Genetic Test analyzes COMT Val158Met — the single variant that most directly determines how quickly your body clears catechol estrogens in Phase 2 metabolism. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your COMT genotype explains why two women with identical estrogen levels can experience hormonal balance very differently.