PDE5 pathway support compounds work differently for different men because the upstream signal they amplify — eNOS-derived nitric oxide — is genetically variable. NOS3 genotype sets the vascular floor. The Precision Peptide Genetic Test maps this and other pathway variables across 14 pathways, 49 peptides, and 150+ genetic insights, explaining the response variability that dosing alone cannot.

PDE5 pathway support works differently for different people — and genetics is one of the most direct explanations for that variability. The Precision Peptide Genetic Test maps upstream NOS3 and downstream pathway variables as part of 14 pathways, 49 peptides, and 150+ genetic insights, explaining the vascular dimension of differential response.

eNOS — the endothelial nitric oxide synthase enzyme encoded by NOS3 — is the genetic starting point of the vascular cascade that sexual arousal depends on. The Precision Peptide Genetic Test analyzes NOS3 variants as part of 14 pathways, 49 peptides, and 150+ genetic insights, mapping the upstream NO signal before it reaches the PDE5 pathway.

The Precision Peptide Genetic Test analyzes 6 Sexual Health insights covering the four systems behind sexual response — vascular (eNOS, PDE5), dopamine (DRD2), bonding (OXTR), and circadian (MTNR1B) — within 14 pathways, 49 peptides, and 150+ genetic insights. This pillar breaks down what each gene reveals and why sexual health is a multi-system problem.