Can you use an HSA on tirzepatide? Usually yes, when a licensed clinician prescribes it for a diagnosed condition. We compare how Eden, MEDVi, Ro, LillyDirect, and PlexusDx handle HSA at checkout, what 30–40% pre-tax savings looks like in real dollars, and where PlexusDx Tirzepatide Injection ($229–$309/mo), Tirzepatide Oral ($229–$509/mo), and GLP-Squared ($179–$325/mo) fit. PlexusDx accepts HSA card payment where your plan permits and does not directly bill.