Health Education Articles | PlexusDx – Tagged "free-testosterone"

Healthcare provider discussing SHBG genetics and TRT response with a male patient — PlexusDx Precision Peptide Genetic Test

Does SHBG Genetics Affect TRT? What Providers Should Know

Yes — SHBG genetics directly affect how free testosterone responds to androgen-pathway protocols. The Precision Peptide Genetic Test analyzes SHBG variants as part of 14 pathways and 150+ genetic insights across 49 peptides, giving providers the genetic context to understand why the same protocol produces different free testosterone outcomes in different men.

Man reviewing SHBG genetics and free testosterone variability — PlexusDx Precision Peptide Genetic Test

SHBG Genetics: Why Your Free Testosterone Varies

SHBG — sex hormone-binding globulin — determines how much of your testosterone is biologically available to cells. High SHBG binds more testosterone, reducing free levels; low SHBG releases more. SHBG gene variants shape your baseline level genetically. The Precision Peptide Genetic Test analyzes SHBG as part of Men’s Hormone insights across 14 pathways, 49 peptides, and 150+ genetic insights.

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