Woman reviewing whether COMT variants affect estrogen dominance — PlexusDx Precision Peptide Genetic Test

Does COMT Affect Estrogen Dominance? What the Genetics Show

Yes — COMT Val158Met directly shapes estrogen clearance speed, and slow COMT genotypes can contribute to the functional estrogen accumulation associated with estrogen dominance. The Precision Peptide Genetic Test analyzes COMT as part of 14 pathways, 49 peptides, and 150+ genetic insights — revealing your clearance baseline before symptoms or protocols make it relevant.