Health Education Articles | PlexusDx

Mature adult representing the MTHFR genetics and longevity connection — PlexusDx Precision Peptide Genetic Test

MTHFR and Longevity: Are They Connected? What the Science Shows

Yes — MTHFR C677T and A1298C connect to longevity through at least five distinct biological mechanisms, from vascular aging and epigenetic clock acceleration to glutathione substrate depletion and DNA repair impairment. The Precision Peptide Genetic Test maps MTHFR within 14 pathways, 49 peptides, and 150+ genetic insights, revealing how your methylation genetics shapes your aging biology.

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