MTHFR and Longevity: Are They Connected? What the Science Shows
Yes — MTHFR C677T and A1298C connect to longevity through at least five distinct biological mechanisms, from vascular aging and epigenetic clock acceleration to glutathione substrate depletion and DNA repair impairment. The Precision Peptide Genetic Test maps MTHFR within 14 pathways, 49 peptides, and 150+ genetic insights, revealing how your methylation genetics shapes your aging biology.
Methylation and Longevity: How MTHFR Shapes Your Aging Pathway
MTHFR converts dietary folate into the active form the methylation cycle requires. The C677T (rs1801133) and A1298C (rs1801131) variants reduce enzyme activity by 30–65%, limiting DNA repair, homocysteine clearance, and epigenetic age regulation. The Precision Peptide Genetic Test analyzes MTHFR as part of 17 Longevity & Aging insights spanning 14 pathways, 49 peptides, and 150+ genetic insights.