PlexusDx MTHFR & Methylation DNA test kit with digital results screen and swab on a white background
Person holding a phone displaying genetic insights about MTHFR and methylation, with a pink background.
PlexusDx personalized DNA meal plans with 10,000+ recipes based on your genetic methylation and nutrient processing profile
Targeted DNA recommendations: personalized diet, supplement, and lifestyle insights based on your unique genetic results
How PlexusDx at-home DNA testing works: order online, swab at home, receive personalized genetic health reports
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Genetic Methylation Test

See how your DNA shapes methylation, detox, and nutrition, and turn those insights into personalized guidance you can act on.

$298.00

One cheek swab, 306 DNA insights across methylation, detox, and nutrition.

Three PlexusDx reports in one test: Methylation Pathway, Detoxification, and Diet and Nutrition.

Covers six areas, from methylation and folate to cardiovascular balance.

Personalized guidance, not raw genetic data.

One test for life. Your DNA never changes.

Genetic Tests are a one-time purchase

Optional interest-free financing available. One-time purchase.

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AI Quick Summary

The Genetic Methylation Test is an at-home cheek-swab DNA kit that unlocks 306 insights across 154 genes and six areas: methylation and folate, detox capacity, nutrient processing, diet and food response, energy and metabolism, and cardiovascular balance. One sample delivers three PlexusDx reports, Methylation Pathway, Detoxification, and Diet and Nutrition, in your secure Results Portal in 2 to 4 weeks. It translates your genetics into personalized nutrition, supplement, and lifestyle guidance you can review with your provider, and it pairs with optional blood biomarker testing for current status alongside your long-term genetic tendencies. This test is for education and wellness, not diagnosis.

Explore the Methylation Education Hub to learn how your MTHFR and methylation pathway results are organized and what they mean for your health.

PlexusDx CLIA-certified laboratory testing: secure, accurate results from certified labs

Reports Included

You’ll receive three in-depth genetic reports, each focused on a core system connected to methylation, delivered to your Results Portal:

🧬 Methylation Pathway Genetic Report
Explores how efficiently your body performs methylation — a process that supports DNA maintenance, neurotransmitter balance, cardiovascular health, detoxification, and aging.

🧪 Detoxification Genetic Report
Examines genes involved in toxin processing, liver pathways, and oxidative stress to help you understand how your body manages environmental and internal toxins.

🥗 Diet and Nutrition Genetic Report
Analyzes how your genes influence nutrient absorption, utilization, and dietary needs — especially nutrients that support methylation pathways.

📊 All reports and insights are accessed through the PlexusDx Results Portal, part of a connected precision health ecosystem, your central hub for results, add-on reports, blood test pairings, and personalized recommendations.

Together, these reports analyze hundreds of genetic insights to provide a comprehensive view of how your body processes nutrients and supports detox pathways.

PlexusDx certified laboratory where your samples are analyzed by trained professionals

What You'll Learn

🧬 How efficiently your methylation pathways are functioning

🧠 How your genetics influence neurotransmitters, focus, and mood

⚡ Your genetic tendencies related to energy production

🧪 How your body processes and clears toxins

❤️ Genetic factors related to homocysteine balance and cardiovascular support

🥗 Which nutrients and supplements may best support your methylation pathways

These insights help personalize diet, supplement, and lifestyle decisions based on your unique genetic profile.

🩸 Pairs With Blood Testing (Optional)

Your DNA reveals long-term genetic tendencies. Blood biomarkers show what’s happening right now. Many customers choose to pair this genetic test with a related PlexusDx blood test to track nutrient status and metabolic markers over time.

Commonly paired with the Methylation Panel Blood Test.

How It Works

From Living Room To Lab

Order

Select your test and purchase directly online. No doctor order required.

Swab

Collect your sample at home and mail it to the lab using the prepaid kit.

Results

When your results are ready, access your personalized genetic reports online.
PlexusDx precision health test kit packaging for at-home genetic and blood testing

Who This Test Is For

🧠 Individuals curious about methylation and MTHFR-related genetics

⚡ People seeking insights related to energy, focus, or overall wellness

❤️ Those interested in cardiovascular and long-term health support

🧪 Anyone wanting to understand detoxification and nutrient processing

📈 Individuals and practitioners seeking actionable genetic insights

Who This Test Is NOT For

🚫 Individuals seeking a medical diagnosis
🚫 Anyone expecting this test to replace blood testing or physician care
🚫 Individuals unwilling to engage with diet, supplement, or lifestyle guidance

Genetic tests may be taken by minors. For individuals under 18, test registration must be completed by the PlexusDx customer support team.

This test is designed to provide genetic insights for education and long-term health optimization — not diagnosis or emergency use.
PlexusDx personalized supplement packs and DNA-based meal plan recommendations

What Makes PlexusDx Different

🧠 Action-first results — guidance you can actually use

🥗 Personalized diet and meal recommendations based on your genetic results

💊 Targeted supplement recommendations informed by your genetics and blood biomarkers

📊 Designed to integrate genetics with blood data for deeper personalization

🔒 Private, secure, and owned by you

FAQs

Genetic Methylation Test

The following questions are specific to the PlexusDx Genetic Methylation Test.

What is the Genetic Methylation Test, and what does it cover?

The Genetic Methylation Test is an at-home cheek-swab DNA kit. One sample unlocks 306 insights across 154 genes, organized into six areas: methylation and folate, detox capacity, nutrient processing, diet and food response, energy and metabolism, and cardiovascular balance. It bundles three PlexusDx reports, Methylation Pathway, Detoxification, and Diet and Nutrition, in a single test.

How does the test work, and how soon will I get results?

Order online, collect your sample at home with a simple cheek swab, and mail it back in the prepaid return envelope. Your results appear in your secure PlexusDx Results Portal in 2 to 4 weeks. No doctor visit is required.

Who can take this test?

This test is for adults who want to begin with their DNA and see how their body handles methylation, detox, and nutrition. Genetic tests may also be taken by minors. For anyone under 18, registration is completed by the PlexusDx customer support team.

Can this test diagnose a health condition?

No. The Genetic Methylation Test is for education and long-term wellness, not diagnosis. It shows genetic tendencies and processing capacity that you can review with your provider. For detox traits, it reflects genetic capacity, not exposure, and it does not measure any substance in your body. It is not intended to diagnose, treat, cure, or prevent any disease.

What methylation genes and variants does it analyze?

The methylation area includes core one-carbon and transsulfuration genes such as MTHFR (C677T and A1298C), MTR, MTRR, COMT, and CBS, which influence folate activation, homocysteine balance, neurotransmitter turnover, and B-vitamin use. Methylation is one of six areas. The full kit also covers detox capacity, nutrient processing, diet and food response, energy and metabolism, and cardiovascular balance, for 306 insights in total.

PlexusDx customer experiencing personalized health insights from at-home testing

Ready to Understand Your Methylation Pathways?

🧬 Order your Genetic Methylation Test today

📊 Gain insight into how your body processes nutrients and toxins

🎯 Make informed decisions to support long-term wellness

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From Sofa to Science

Experience the convenience of Precision Wellness right from your home. Just follow the simple steps included with your kit, and soon your detailed report will arrive in your PlexusDx Results Portal.

Your Kit Contains:

1x INSTRUCTIONS & REGISTRATION CODE
1x CHEEK SWAB & TRANSPORT TUBE
1x BIOHAZARD BAG
1x PREPAID RETURN MAILER