In the Precision Peptide Genetic Test, the Reproductive Health pathway delivers 6 insights across the genes governing estrogen Phase 1 metabolism, Phase 2 clearance, methylation supply, and receptor sensitivity. Part of 14 pathways, 49 peptides, and 150+ genetic insights, these 6 variants map women's estrogen biology as a connected system — not a checklist of isolated traits.

HRT works differently for every woman because the biological systems that process estrogen are individually variable — and genetics is the layer that explains those differences most precisely. The Precision Peptide Genetic Test maps six variables across 14 pathways, 49 peptides, and 150+ genetic insights that determine how your body handles any hormone support protocol.

Yes — COMT Val158Met directly shapes estrogen clearance speed, and slow COMT genotypes can contribute to the functional estrogen accumulation associated with estrogen dominance. The Precision Peptide Genetic Test analyzes COMT as part of 14 pathways, 49 peptides, and 150+ genetic insights — revealing your clearance baseline before symptoms or protocols make it relevant.

Multiple genes shape estrogen levels in women — from production through metabolism to clearance and receptor response. The Precision Peptide Genetic Test analyzes the key variants across 14 pathways, 49 peptides, and 150+ genetic insights, giving providers the genetic picture that estradiol blood tests alone cannot deliver.

The Precision Peptide Genetic Test maps the genetic variables that shape how you experience the menopause transition — from vasomotor symptom intensity to bone density trajectory to mood changes. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your Reproductive Health panel explains why menopause feels profoundly different from one woman to the next.

The Precision Peptide Genetic Test analyzes GSTM1 and GSTT1 — the glutathione S-transferase genes whose null deletions eliminate the tertiary Phase 2 backstop against reactive estrogen quinones. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your GSTM1 and GSTT1 deletion status determines whether glutathione conjugation is available when COMT and SULT1A1 clearance is insufficient.

Two women begin the same hormone support protocol on the same day. Weeks later, one feels significantly better — symptoms eased, energy restored. The other notices little change or unwanted effects. The Precision Peptide Genetic Test maps six biological variables across 14 pathways and 150+ genetic insights that explain this gap — not chance, but genetics.

The Precision Peptide Genetic Test analyzes SULT1A1 — the sulfotransferase enzyme that runs a methylation-independent route to estrogen clearance. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your SULT1A1 Arg213His genotype determines how quickly sulfation neutralizes estradiol and its metabolites for excretion — a parallel Phase 2 pathway that COMT genetics alone cannot capture.

The Precision Peptide Genetic Test analyzes ESR1 and ESR2 — the two estrogen receptor genes that determine how sensitively your tissues respond to circulating estrogen. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your estrogen receptor variants explain why the same estradiol level produces very different biological effects in different women.

The Precision Peptide Genetic Test analyzes MTHFR C677T and A1298C — the variants that set your methylation capacity and determine how efficiently your body produces the SAMe that estrogen clearance depends on. Part of 14 pathways, 49 peptides, and 150+ genetic insights, MTHFR is the upstream genetic variable that connects the methylation cycle to women's hormone balance.

The Precision Peptide Genetic Test analyzes COMT Val158Met — the single variant that most directly determines how quickly your body clears catechol estrogens in Phase 2 metabolism. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your COMT genotype explains why two women with identical estrogen levels can experience hormonal balance very differently.

The Precision Peptide Genetic Test analyzes CYP1A1 and CYP1B1 — the two Phase 1 enzymes that determine which metabolic route estradiol takes after it leaves circulation. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your CYP1A1 and CYP1B1 variants set the 2-OHE2 to 4-OHE2 ratio that shapes your estrogen biology from the inside out.

Aromatase activity varies between men because CYP19A1 — the gene encoding aromatase — is polymorphic. Different CYP19A1 variants alter how the enzyme is expressed and how efficiently it converts testosterone to estradiol. The Precision Peptide Genetic Test analyzes CYP19A1 as part of 14 pathways and 150+ genetic insights across 49 peptides.

Genetics shapes estrogen in men through four pathways: how much testosterone converts to estradiol (CYP19A1), how efficiently it clears (COMT, MTHFR), how sensitively tissues respond (ESR1), and how much substrate is available (SHBG, SRD5A2). The Precision Peptide Genetic Test maps all these variables across 14 pathways and 150+ genetic insights.