Male patient discussing MTHFR methylation and male hormone optimization — PlexusDx Precision Peptide Genetic Test

MTHFR and Methylation: How They Shape Male Hormone Optimization

The Precision Peptide Genetic Test analyzes MTHFR C677T and A1298C — the variants that determine your methylation capacity and its downstream effects on estrogen clearance, homocysteine levels, and hormone metabolism. Part of 14 pathways and 150+ genetic insights across 49 peptides, MTHFR is the genetic variable connecting methylation to the male hormone system.

Healthcare provider discussing SHBG genetics and TRT response with a male patient — PlexusDx Precision Peptide Genetic Test

Does SHBG Genetics Affect TRT? What Providers Should Know

Yes — SHBG genetics directly affect how free testosterone responds to androgen-pathway protocols. The Precision Peptide Genetic Test analyzes SHBG variants as part of 14 pathways and 150+ genetic insights across 49 peptides, giving providers the genetic context to understand why the same protocol produces different free testosterone outcomes in different men.

Man consulting a clinician on the genes that affect testosterone levels — PlexusDx Precision Peptide Genetic Test

What Genes Affect Testosterone Levels? The Complete Genetic Guide

The Precision Peptide Genetic Test analyzes six Reproductive Health genes that directly influence testosterone levels, conversion, and signaling — including SHBG, CYP19A1, AR, SRD5A2, LHCGR, and CYP17A1. Part of 14 pathways and 150+ genetic insights across 49 peptides, these variants explain why testosterone behaves differently in different men.

Man on TRT reviewing the genetic factors behind individual response — PlexusDx Precision Peptide Genetic Test

Why TRT Works for Some Men and Not Others: The Genetic Answer

The Precision Peptide Genetic Test analyzes 6 Reproductive Health insights that explain why androgen-pathway protocols produce different outcomes for different men. SHBG, CYP19A1, AR, SRD5A2, LHCGR, and CYP17A1 each shape how testosterone is bound, converted, sensed, and signaled — as part of 14 pathways and 150+ genetic insights across 49 peptides.

Male patient discussing DHEA and pregnenolone pathway genetics — PlexusDx Precision Peptide Genetic Test

DHEA and Pregnenolone Pathway Genetics: What Your DNA Reveals

The Precision Peptide Genetic Test analyzes CYP17A1 and related variants — the genes governing DHEA and pregnenolone synthesis in your adrenal androgen pathway. Part of 14 pathways and 150+ genetic insights across 49 peptides, your upstream steroid pathway genetics explain why the same hormonal support strategies produce different results across different men.

Male patient discussing SRD5A2 5-alpha reductase and DHT conversion genetics — PlexusDx Precision Peptide Genetic Test

SRD5A2 and 5-Alpha Reductase Genetics: DHT Conversion in Men

The Precision Peptide Genetic Test analyzes SRD5A2 — the gene controlling 5-alpha reductase, the enzyme that converts testosterone into DHT. Part of 14 pathways and 150+ genetic insights across 49 peptides, your SRD5A2 variants determine how much testosterone is routed toward the androgen pathway's most potent signaling molecule.

Man reviewing HPTA axis LH and FSH genetics for fertility preservation — PlexusDx Precision Peptide Genetic Test

HPTA Axis Genetics: LH, FSH, and Fertility Preservation in Men

The Precision Peptide Genetic Test analyzes LH and FSH receptor variants — the genes governing how sensitively your HPTA axis signals testosterone production and sperm health. Part of 14 pathways and 150+ genetic insights across 49 peptides, your HPTA genetics help explain why fertility preservation strategies matter differently for different men on androgen-pathway protocols.

Man reviewing androgen receptor CAG repeat sensitivity genetics — PlexusDx Precision Peptide Genetic Test

Androgen Receptor CAG Repeats: Sensitivity Explained

The Precision Peptide Genetic Test analyzes AR CAG repeats — the genetic variable that determines how sensitively your androgen receptor responds to testosterone. Part of 14 pathways and 150+ genetic insights across 49 peptides, CAG repeat length helps explain why two men with identical testosterone levels can have completely different androgen responses.

Male patient discussing CYP19A1 aromatase and estrogen conversion genetics — PlexusDx Precision Peptide Genetic Test

CYP19A1 (Aromatase) and Estrogen Conversion in Men

The Precision Peptide Genetic Test analyzes CYP19A1 — the aromatase gene that controls how much testosterone your body converts to estrogen. Part of 14 pathways and 150+ genetic insights across 49 peptides, your CYP19A1 variants help explain why estrogen levels vary between men on the same androgen-pathway protocol.

Clinician reviewing men's hormone genetic testing with a male patient — PlexusDx Precision Peptide Genetic Test

Complete Guide to Genetic Men's Hormone Testing: 6 Pathway Insights

The Precision Peptide Genetic Test analyzes 6 Reproductive Health insights covering men's hormone pathways — SHBG, CYP19A1, AR, SRD5A2, and LH/FSH receptor variants — within a panel of 14 pathways, 49 peptides, and 150+ genetic insights. This pillar guide breaks down each gene, what it reveals about testosterone response, and why DNA is the most underused variable in hormone protocols.

Man reviewing SHBG genetics and free testosterone variability — PlexusDx Precision Peptide Genetic Test

SHBG Genetics: Why Your Free Testosterone Varies

SHBG — sex hormone-binding globulin — determines how much of your testosterone is biologically available to cells. High SHBG binds more testosterone, reducing free levels; low SHBG releases more. SHBG gene variants shape your baseline level genetically. The Precision Peptide Genetic Test analyzes SHBG as part of Men’s Hormone insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Athlete stretching post-workout representing genetics and muscle recovery — PlexusDx Precision Peptide Genetic Test

How Does Genetics Affect Muscle Recovery?

Recovery is where muscle growth actually happens — and your genetics determine how quickly and completely that process runs. IL-6, ACTN3, IGF1, GHSR, VDR, and ACE variants all shape different dimensions of post-exercise repair. The Precision Peptide Genetic Test analyzes all of them across 15 Muscle Growth insights spanning 14 pathways, 49 peptides, and 150+ genetic insights.

Competitive athlete representing genetic testing for athletic performance — PlexusDx Precision Peptide Genetic Test

Can Genetic Testing Predict Athletic Performance?

Not exactly — but it reveals the biological architecture athletic training response is built on. Genetic testing maps predispositions in fiber type (ACTN3), cardiovascular optimization (ACE), anabolic capacity (IGF1), and recovery (IL-6). The Precision Peptide Genetic Test delivers 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Strength athlete representing myostatin blocker genetics research — PlexusDx Precision Peptide Genetic Test

Myostatin Blockers and Genetics: What the Research Shows

Myostatin — encoded by the MSTN gene — is one of the most actively researched muscle growth regulators in exercise science. Your MSTN genotype determines how tightly this brake is set before any intervention. The Precision Peptide Genetic Test analyzes MSTN variants as part of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Fit athlete representing the genes that affect growth hormone response — PlexusDx Precision Peptide Genetic Test

What Genes Affect Growth Hormone Response?

Multiple genes shape growth hormone response — from GHSR, which triggers GH pulses from the pituitary, to IGF1, which converts that signal into anabolic action, to ACTN3 and MSTN, which determine what the signal builds. The Precision Peptide Genetic Test analyzes all of them as part of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Gym-goer representing the genetics behind why muscle building response varies — PlexusDx Precision Peptide Genetic Test

Why Don't I Build Muscle? Your Genetics May Have Answers

Struggling to build muscle despite consistent training? Genetics may be the missing variable. MSTN, ACTN3, IGF1, GHSR, and VDR variants all influence how your body responds to resistance training stimulus — from hypertrophy ceiling to anabolic signal strength to fiber architecture. The Precision Peptide Genetic Test analyzes 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Muscular athlete representing the ACTN3 gene and muscle growth genetics — PlexusDx Precision Peptide Genetic Test

Does ACTN3 Affect Muscle Growth?

Yes — ACTN3 affects muscle growth by determining your fast-twitch versus slow-twitch fiber ratio, which shapes how aggressively your muscle fibers hypertrophy. The R577X variant produces three genotypes (RR, RX, XX) with meaningfully different hypertrophy profiles. The Precision Peptide Genetic Test analyzes ACTN3 as one of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Fit adult representing genetics of the growth hormone axis peptide response — PlexusDx Precision Peptide Genetic Test

How Your Genetics Shape Growth Hormone Axis Peptide Response

Your response to growth hormone axis pathways isn’t shaped by a single gene — it’s the product of at least eight interacting genetic factors, from GH release (GHSR) to fiber architecture (ACTN3) to recovery capacity (IL-6). The Precision Peptide Genetic Test analyzes all as part of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Athlete recovering post-workout representing IL-6 inflammation and muscle recovery genetics — PlexusDx Precision Peptide Genetic Test

IL-6 and Recovery: The Inflammation–Muscle Connection

IL-6 is widely known as an inflammatory cytokine — but in muscle biology it also functions as a myokine: a recovery signal produced by contracting muscle that drives satellite cell activation and repair. The Precision Peptide Genetic Test analyzes IL6 variants as one of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Athlete representing ACE gene endurance versus power performance genetics — PlexusDx Precision Peptide Genetic Test

ACE Gene: Endurance vs Power Athlete Genetics

The ACE gene’s I/D polymorphism is one of the most replicated findings in sport genetics — separating endurance-optimized physiology (I allele) from power-optimized physiology (D allele) through cardiovascular architecture rather than fiber structure alone. The Precision Peptide Genetic Test analyzes ACE as one of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Active adult representing VDR vitamin D receptor and muscle performance genetics — PlexusDx Precision Peptide Genetic Test

Vitamin D Receptor (VDR) and Muscle Performance

Vitamin D levels get all the attention — but VDR, the gene encoding the vitamin D receptor, determines whether those levels actually translate into muscle function. VDR variants influence protein synthesis, calcium handling, and satellite cell activity. The Precision Peptide Genetic Test analyzes VDR as one of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Fit adult representing GHSR ghrelin receptor genetics and growth hormone release — PlexusDx Precision Peptide Genetic Test

The GHSR Ghrelin Receptor: Genetics of GH Release

The GHSR gene encodes the ghrelin receptor — the trigger that initiates growth hormone pulses from the pituitary. GHSR variants shape the amplitude and frequency of GH output upstream of IGF-1 production. The Precision Peptide Genetic Test analyzes GHSR as one of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Strength athlete representing IGF-1 genetics and growth hormone axis response — PlexusDx Precision Peptide Genetic Test

IGF-1 Genetics and Growth Hormone Axis Response

IGF-1 — the primary mediator of growth hormone signaling — converts GH axis activation into muscle growth, tissue repair, and anabolic adaptation. The Precision Peptide Genetic Test analyzes IGF1 variants as part of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights — revealing how efficiently your biology converts growth hormone signals into action.

Muscular athlete representing myostatin MSTN genetics and muscle mass — PlexusDx Precision Peptide Genetic Test

Myostatin (MSTN) and Muscle Mass: What Your Genetics Reveal

Myostatin — encoded by the MSTN gene — is the body’s primary biological brake on muscle mass accumulation. The Precision Peptide Genetic Test analyzes MSTN variants as part of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights — revealing how tightly your genetics constrain your hypertrophy ceiling.

Sprinting athlete representing the ACTN3 sprint gene and muscle fiber type — PlexusDx Precision Peptide Genetic Test

ACTN3 and Muscle Fiber Type: The “Sprint Gene” Explained

The ACTN3 R577X variant — known as the “sprint gene” — determines your muscle fiber type composition, shaping how your body builds power, recovers from training, and responds to growth hormone axis pathways. The Precision Peptide Genetic Test includes ACTN3 as one of 15 Muscle Growth insights across 14 pathways, 49 peptides, and 150+ genetic insights.

Fit athlete representing genetic muscle growth testing and 15 pathway insights — PlexusDx Precision Peptide Genetic Test

Complete Guide to Genetic Muscle Growth Testing: 15 Pathway Insights

The Precision Peptide Genetic Test analyzes 15 muscle growth insights — ACTN3, IGF1, MSTN, GHSR, and GHR — within a panel of 14 pathways, 49 peptides, and 150+ genetic insights. This pillar guide breaks down each muscle gene, what it reveals about fiber type and growth response, and why your DNA is the most underused variable in any muscle protocol.

Healthcare professional explaining the longevity-aging pathway in genetic testing — PlexusDx Precision Peptide Genetic Test

What Is the Longevity-Aging Pathway in Genetic Testing?

The Longevity-Aging pathway in the Precision Peptide Genetic Test delivers 17 insights organized across five functional clusters — antioxidant defense, NAD+ homeostasis, methylation, longevity transcription factors, and structural aging biology. Part of 14 pathways, 49 peptides, and 150+ genetic insights, these 17 variants map biological aging as a connected system, not a list of isolated risk genes.

Healthy adult representing the genetics of antioxidant capacity — PlexusDx Precision Peptide Genetic Test

How Does Genetics Affect Antioxidant Capacity? A Complete Guide

Antioxidant capacity is not a single number — it is the combined genetic output of five overlapping enzyme systems, each with its own variant layer. The Precision Peptide Genetic Test maps SOD2, GPX1, GCLC, NFE2L2, FOXO3, and more across 14 pathways, 49 peptides, and 150+ genetic insights, revealing the genetic architecture your antioxidant biology is built on.

Mature adult representing the MTHFR genetics and longevity connection — PlexusDx Precision Peptide Genetic Test

MTHFR and Longevity: Are They Connected? What the Science Shows

Yes — MTHFR C677T and A1298C connect to longevity through at least five distinct biological mechanisms, from vascular aging and epigenetic clock acceleration to glutathione substrate depletion and DNA repair impairment. The Precision Peptide Genetic Test maps MTHFR within 14 pathways, 49 peptides, and 150+ genetic insights, revealing how your methylation genetics shapes your aging biology.

Healthy adult representing the genes that affect glutathione production — PlexusDx Precision Peptide Genetic Test

What Genes Affect Glutathione Production? Your Genetic Guide

Glutathione synthesis, recycling, and detoxification capacity are all genetically variable — GCLC, GCLM, GSR, GPX1, GSTM1, and NFE2L2 each shape a different step. The Precision Peptide Genetic Test maps these variants across 14 pathways, 49 peptides, and 150+ genetic insights, revealing where your antioxidant production is genetically strongest and where it leaks.