HSA | FSA CARDS ARE NOW ACCEPTED

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

ADRB2 and Cardiac Output: What Your Genotype Means for Heart Performance

Cardiac output is the amount of blood the heart pumps each minute. It is a key driver of oxygen and nutrient delivery to muscles and organs, especially during exercise. The ADRB2 gene helps control how your heart and blood vessels respond to adrenaline and other stress signals. Variations in ADRB2 can change how strongly those signals work, which may affect how well your heart adapts to exertion and stress.

This article explains how common variants of the ADRB2 rs1042713 single nucleotide polymorphism can influence cardiac output and exercise adaptation. It also provides practical, evidence-informed strategies for diet, supplements, and lifestyle that support healthy heart function. PlexusDx does not provide medical advice. Always consult your healthcare provider before making changes to medications, supplements, or major lifestyle routines.

How ADRB2 Affects Heart Function

  • ADRB2 encodes the beta-2 adrenergic receptor, a protein on heart and blood vessel cells that responds to adrenaline and noradrenaline.
  • When activated, this receptor can increase heart rate, improve blood flow to skeletal muscle, and modify how the heart pumps blood during stress or exercise.
  • Differences in ADRB2 may change receptor function or expression, subtly altering cardiac output at rest and during activity.

Practical Implications

Regardless of genotype, you can support healthy cardiac output by focusing on regular aerobic fitness, balanced nutrition, stress management, sleep, and avoiding excessive stimulants. Below are targeted suggestions that complement your genetic background.

Recommendations to Support Cardiac Output

Exercise

  • Aim for at least 150 minutes per week of moderate aerobic activity or 75 minutes of vigorous activity, plus two strength sessions weekly.
  • Include steady-state cardio like brisk walking, cycling, or swimming to build endurance and improve stroke volume and cardiac output.
  • Add interval training once or twice weekly to boost cardiovascular efficiency. Start gently and increase intensity under the guidance of your healthcare provider if needed.

Nutrition

  • Prioritize a diet rich in vegetables, fruits, whole grains, lean proteins, and healthy fats.
  • Include omega-3 rich foods such as fatty fish, walnuts, and flaxseed to support vascular health and reduce inflammation.
  • Choose antioxidant rich foods like berries, leafy greens, and colorful vegetables to protect cardiovascular tissues from oxidative stress.
  • Limit excessive sodium and highly processed foods to support healthy blood pressure and heart workload.

Hydration and Stimulants

  • Maintain regular hydration before, during, and after exercise to support blood volume and cardiac output.
  • Avoid excessive caffeine, energy drinks, or stimulants that can provoke rapid heart rate or irregular responses, especially if you have known heart conditions or sensitivity.

Sleep and Stress Management

  • Aim for 7 to 9 hours of quality sleep per night. Poor sleep can raise resting heart rate and reduce recovery capacity.
  • Use relaxation practices such as deep breathing, meditation, yoga, or progressive muscle relaxation to temper adrenergic activation and support steady cardiovascular responses.

Supplements to Consider

Talk with your healthcare provider before starting supplements, especially if you take medications or have medical conditions.

  • Omega-3 fatty acids (EPA/DHA) to support vascular function and reduce inflammation.
  • Magnesium to support normal muscle and nerve function, including the heart.
  • Coenzyme Q10 for cellular energy support in cardiac tissue, particularly if you are on statin therapy.
  • Potassium-rich foods or supplements if advised by your clinician, to help maintain healthy blood pressure and heart rhythm.

Genetic Interpretation: rs1042713 (ADRB2)

2 effect alleles (GG)

You have two copies of the effect allele at rs1042713 (genotype GG). This variant is associated with an enhanced cardiac output response at rest and during exercise. Your heart may pump a greater volume of blood per minute when exercising, which can support improved oxygen and nutrient delivery to muscles and organs. This genetic profile may be advantageous for endurance performance and efficient cardiovascular adaptation.

What this means for you

  • You may see stronger aerobic performance and faster recovery of blood flow during exercise.
  • Focus on progressive endurance training to maximize the advantage and maintain balanced strength work to prevent overuse injuries.
  • Pay attention to hydration and avoid excessive stimulants that might exaggerate adrenergic responses.
1 effect allele (AG)

You carry one copy of the effect allele at rs1042713 (genotype AG). Your cardiac response to adrenaline and exercise tends to be intermediate between the two homozygous states. You may have a moderate capacity for increasing cardiac output with training and stress.

What this means for you

  • Consistent aerobic training can help improve cardiovascular efficiency and oxygen delivery.
  • Balance endurance sessions with strength and mobility work to build overall performance and reduce injury risk.
  • Implement stress reduction and sleep optimization to support recovery and steady heart responses.
0 effect alleles (AA)

You have two copies of the non-effect allele at rs1042713 (genotype AA). This profile is associated with average cardiac output characteristics. Your heart function during rest and exercise likely falls within the typical population range.

What this means for you

  • Standard evidence-based approaches to cardiovascular fitness are effective: regular aerobic exercise, progressive training, and good recovery practices.
  • Focus on a heart healthy diet rich in omega-3s and antioxidants and maintain consistent sleep and stress management routines.
  • Monitor exercise intensity and consult a clinician before beginning high intensity or competitive training if you have underlying cardiac risks.

When to Talk with Your Healthcare Provider

  • If you experience unexplained chest pain, dizziness, fainting, irregular heartbeat, or shortness of breath during activity.
  • If you have a personal or family history of heart disease, arrhythmia, or high blood pressure.
  • Before starting high intensity training, competitive sports, or new supplements, especially if you take prescription medications.

PlexusDx provides educational information about genetic predispositions. This information is not medical advice. Always consult your healthcare provider to interpret genetic results in the context of your health history and to make personalized medical decisions.

If this genetic variant is present in your PlexusDx results, the following tests and reports are commonly used to explore it further:

🧬 Genetic Tests:

🧪 Blood Tests:

📄 Genetic Report:

Frequently Asked Questions About Cardiac Output and ADRB2 rs1042713

What does the ADRB2 rs1042713 genotype mean for my cardiac output?

The ADRB2 rs1042713 variant influences how strongly your beta-2 adrenergic receptor responds to adrenaline and noradrenaline. This can affect your heart’s ability to increase cardiac output at rest and during exercise, which in turn can shape oxygen and nutrient delivery during physical activity.

How do different ADRB2 rs1042713 genotypes (GG, AG, AA) affect exercise adaptation?

Genotype GG is associated with an enhanced cardiac output response at rest and during exercise, supporting efficient cardiovascular adaptation. Genotype AG typically shows an intermediate response, with moderate capacity to increase cardiac output with training and stress. Genotype AA is associated with average cardiac output characteristics, where standard cardiovascular training and recovery strategies are likely most effective.

What lifestyle strategies can help support healthy heart performance with ADRB2 rs1042713?

Regardless of genotype, supporting cardiac output comes from regular aerobic fitness (including steady-state and some interval work), a heart-healthy diet rich in vegetables, whole grains, lean proteins, omega-3s, and antioxidants, and limiting excessive sodium and highly processed foods. Hydration, adequate sleep (7–9 hours), stress management (breathing, meditation, yoga, or relaxation), and avoiding excessive stimulants can also help support steady cardiovascular responses. If considering supplements like omega-3s, magnesium, coenzyme Q10, or potassium, discuss them with your healthcare provider first—especially if you take medications or have heart-related conditions.

What tests can help me learn more about Cardiac Output and ADRB2 rs1042713?

The Functional Health Genetic Test delivers over 750 personalized genetic insights across 10 in-depth genetic reports to support whole-body, systems-level health understanding. The Fitness and Injury Genetic Report translates your results into personalized, actionable guidance. Your healthcare provider can also recommend targeted blood tests based on your specific pathway results and health history to complement your genetic insights with current biomarker data.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.