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Understanding Grass Pollen Allergy and the LRRC32 Gene

Grass allergy is a common seasonal condition caused by inhaling grass pollen. Typical symptoms include itchy, watery eyes, sneezing, runny or blocked nose, and throat irritation. How strongly someone reacts to grass pollen depends on a mix of environmental exposures, immune system activity, and genetics. One gene that can influence this response is LRRC32, which helps control immune cells that prevent exaggerated reactions to harmless substances like pollen.

How LRRC32 Affects Immune Response

LRRC32 plays a role in regulating regulatory T cells, a subset of immune cells that keep inflammation in check. Variations in LRRC32 can change how well these regulatory pathways function. In some people, certain variants are associated with a stronger inflammatory response to grass pollen and higher levels of IgE antibodies that drive allergic symptoms. Having one or two copies of an effect allele may increase sensitivity, though it does not guarantee an allergy will develop.

Two effect alleles (TT for rs2155219)

Carrying two copies of the T allele for rs2155219 suggests a higher genetic tendency toward enhanced inflammatory responses to grass pollen. LRRC32 is less likely to fully support regulatory T cells in limiting immune overreaction, which can lead to stronger allergy symptoms such as severe sneezing, itchy eyes, and nasal congestion during grass pollen season. This genotype increases susceptibility but does not ensure symptoms will occur; environment and other genes also matter.

One effect allele (CT for rs2155219)

Having one copy of the T allele indicates a moderate genetic influence. LRRC32 function may be partially altered, which can raise the chance of developing higher IgE levels and an increased inflammatory reaction to grass pollen. People with this genotype may experience more noticeable seasonal symptoms than those without the T allele but typically less severe than those with two copies.

No effect alleles (CC for rs2155219)

Two copies of the C allele mean you do not carry the specific variant linked to greater grass pollen sensitivity at rs2155219. Your LRRC32 gene likely functions in its typical form and better supports regulatory T cell control over inflammation. You can still get seasonal allergies due to environmental triggers or other genetic factors, but this particular marker does not increase your risk.

Practical Steps to Reduce Grass Allergy Symptoms

Genetics are one piece of the puzzle. Whether or not your LRRC32 genotype increases risk, the following diet, supplement, and lifestyle steps can help reduce inflammation and improve symptom control during grass pollen season.

Diet and Nutrition

  • Follow an anti-inflammatory eating pattern: focus on whole foods, plenty of fruits, vegetables, legumes, whole grains, nuts, and seeds.
  • Increase omega-3 fatty acids: eat fatty fish (salmon, mackerel, sardines) 2–3 times per week or use a high-quality omega-3 supplement to support balanced immune responses.
  • Prioritize colorful fruits and vegetables: rich in antioxidants and bioflavonoids that can reduce oxidative stress and inflammation.
  • Include fermented foods and prebiotic fiber: yogurt, kefir, sauerkraut, kimchi, and fiber-rich foods (onions, garlic, asparagus) support a healthy gut microbiome, which influences immune regulation.
  • Limit pro-inflammatory items: reduce processed foods, excessive sugar, and trans fats that can worsen inflammation.

Supplements to Consider

  • Vitamin C: an antioxidant that can reduce histamine levels and support immune health. Consider 500–1,000 mg daily if tolerated.
  • Quercetin: a plant flavonoid with natural antihistamine and anti-inflammatory properties. Typical doses range from 250–500 mg two times daily.
  • Zinc: supports immune function; avoid excessive long-term dosing. A common supplemental dose is 15–30 mg daily with food.
  • Omega-3 (EPA/DHA): 1,000–2,000 mg combined daily can reduce inflammation and allergic responses.
  • Probiotics: a multi-strain probiotic taken daily may support immune balance; choose formulations with clinical strain data if possible.
  • Local honey: limited evidence exists, but some people report symptomatic relief when exposed incrementally to local pollen proteins. Use cautiously and avoid if allergic to honey components.

Always review supplement use with your healthcare provider to avoid interactions and ensure appropriate dosing for your health status.

Lifestyle Strategies

  • Monitor pollen counts and avoid outdoor activity during peak times: early morning and windy days often have the highest pollen levels.
  • Keep windows closed during high pollen seasons and use air conditioning with a clean HEPA or high-efficiency filter.
  • Shower and change clothes after spending time outside to remove pollen from skin and hair.
  • Use nasal irrigation: saline rinses can clear pollen and reduce nasal inflammation. Perform as directed using sterile or boiled-and-cooled water.
  • Wear wraparound sunglasses and a hat outdoors to reduce eye and face exposure to pollen.
  • Manage indoor humidity: maintain relative humidity between 30% and 50% to reduce dust mite growth and mold that can worsen symptoms.
  • Consider allergen-proof bedding covers and wash linens weekly in hot water during peak season.

When to Talk with a Healthcare Provider

  • If symptoms are persistent or worsening despite lifestyle changes and over-the-counter remedies
  • If you have severe symptoms such as difficulty breathing, swelling, or severe sinus pain
  • To discuss prescription options such as nasal corticosteroids, antihistamines, or immunotherapy (allergy shots or sublingual tablets) that may modify long-term allergic responses
  • To review any supplements for safety and interactions with medications

Final Notes and Disclaimer

This information is educational and intended to help you understand how a variation in LRRC32 may influence allergy risk and symptom severity. PlexusDx does not provide medical advice. Always consult your healthcare provider before making medical decisions, starting supplements, or changing treatments based on genetic information.