HSA | FSA CARDS ARE NOW ACCEPTED

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

Understanding Uterine Fibroids and the CCND1 Gene

Uterine fibroids are noncancerous growths that form in the muscular wall of the uterus. They can cause heavy menstrual bleeding, pelvic pain, pressure symptoms, and, in some cases, challenges with fertility. Many factors influence fibroid development, including hormones, environment, and genetics. The CCND1 gene helps regulate how cells progress through the cell cycle. Certain variations in CCND1 can change how uterine smooth muscle cells respond to signals that control growth, potentially affecting fibroid risk.

What this means for you

Your CCND1 genotype can indicate whether you have a higher, moderate, or typical genetic tendency for fibroid development. Regardless of genotype, lifestyle, diet, and environmental exposures can influence uterine health and may help reduce symptoms or slow fibroid growth. The recommendations below are educational and intended to help you discuss options with your healthcare team.

Two effect alleles (AA genotype) — Increased risk

If you have the AA genotype for rs9344, you carry two copies of the effect allele. This genotype is associated with a higher likelihood of developing uterine fibroids. The CCND1 variant linked to AA may increase cell growth signaling in uterine tissue, making uterine smooth muscle cells more responsive to hormonal and environmental triggers.

Lifestyle and dietary suggestions

  • Prioritize a whole foods diet rich in fruits, vegetables, legumes, whole grains, nuts, and seeds.
  • Emphasize polyphenol-rich foods such as berries, kale, beans, apples, and green tea. Polyphenols can modulate inflammation and cellular signaling.
  • Limit intake of processed foods, high-sugar products, and excessive red or processed meats.
  • Reduce or moderate soy and dairy if you notice symptom changes after consumption, and discuss alternatives with your clinician.
  • Maintain a healthy body weight through balanced nutrition and portion control. Adipose tissue affects hormone levels and inflammation.

Supplements and botanicals to discuss with your provider

  • Green tea extract standardized for EGCG
  • Curcumin or turmeric formulations with enhanced absorption
  • Resveratrol
  • Ensure any supplement choice is safe in the context of your medications and health history.

Environmental and lifestyle measures

  • Limit exposure to endocrine disrupting chemicals such as BPA and phthalates. Use glass or stainless steel food containers and choose personal care products labeled free of phthalates.
  • Engage in regular physical activity, including aerobic exercise and resistance training, to support hormonal balance.
  • Aim for 7 to 9 hours of sleep per night and manage stress with evidence based techniques such as mindfulness, yoga, or counseling.

Talk with your healthcare provider about personalized monitoring and symptom management. If fibroid symptoms appear or worsen, imaging and specialist referral may be appropriate.

One effect allele (AG genotype) — Likely increased risk

If you have the AG genotype for rs9344, you carry one copy of the effect allele. This genotype is associated with a likely increased risk of developing uterine fibroids. The CCND1 variant may make uterine smooth muscle cells somewhat more sensitive to hormonal and environmental factors that promote growth.

Practical steps to support uterine health

  • Follow a mostly plant forward diet emphasizing polyphenol rich foods: berries, dark leafy greens like kale, beans, cruciferous vegetables, onions, and garlic.
  • Limit processed and fried foods, and reduce added sugars and refined carbohydrates.
  • Consider moderating soy and dairy if you are concerned about symptom triggers.
  • Maintain regular exercise and aim for a healthy body composition.

Supplements to consider with medical guidance

  • Green tea extract (EGCG)
  • Curcumin
  • Resveratrol

Environmental and prevention tips

  • Choose low chemical personal care and household products to reduce endocrine disruptor exposure.
  • Avoid heating food in plastic, and limit canned foods that may be lined with BPA containing materials.
  • Keep routine gynecologic care and discuss any menstrual changes, pelvic pain, or fertility concerns with your provider promptly.

Work with your clinician to create a monitoring plan. Early recognition of symptoms can support timely management and preserve reproductive health.

No effect alleles (GG genotype) — Typical risk

If you have the GG genotype for rs9344, you carry two copies of the non effect allele and do not have the CCND1 variation associated with increased cell cycle activity in uterine smooth muscle. Your genetic risk for fibroids is considered typical. That does not mean fibroids cannot occur. Lifestyle and environmental factors still play a significant role.

Recommendations for ongoing uterine health

  • Maintain a balanced diet rich in whole foods, fruits, vegetables, legumes, and whole grains.
  • Include polyphenol rich foods like berries, kale, beans, and green tea as part of a varied diet.
  • Limit processed foods and reduce exposure to endocrine disruptors such as BPA and phthalates.
  • Stay active with regular aerobic exercise and strength training, and manage stress and sleep quality.

When to seek care

  • Seek evaluation for heavy or prolonged bleeding, severe pelvic pain, difficulty with fertility, or any new pelvic symptoms.
  • Routine gynecologic exams and appropriate imaging based on symptoms help identify fibroids early when intervention may be helpful.

Practical checklist

  • Eat a colorful, polyphenol rich diet: berries, leafy greens, beans, nuts, and whole grains.
  • Limit processed foods, excessive sugar, and consider moderating soy and dairy if relevant.
  • Consider supplements such as green tea extract, curcumin, and resveratrol only after discussing them with your healthcare provider.
  • Reduce exposure to endocrine disruptors by choosing glass or stainless steel food containers and low chemical personal care products.
  • Stay physically active, prioritize sleep, and use stress reduction strategies.
  • Report menstrual or pelvic changes to your healthcare provider and maintain routine gynecologic care.

Important notice

PlexusDx provides education about genetic predispositions and possible lifestyle supports only. This information is not medical advice. Always consult your healthcare provider before making changes to diet, supplements, medications, or medical care. Your provider can help interpret genetic results in the context of your personal and family medical history and guide appropriate testing, monitoring, and treatment.

If this genetic variant is present in your PlexusDx results, the following tests and reports are commonly used to explore it further:

🧬 Genetic Tests:

🧪 Blood Tests:

📄 Genetic Report:

Frequently Asked Questions About Uterine Fibroids and CCND1 rs9344

What does the CCND1 rs9344 variant mean for my risk of uterine fibroids?

Uterine fibroids are noncancerous growths in the uterine muscle wall, and genetics can influence susceptibility. CCND1 helps regulate cell-cycle progression, and the rs9344 variation may affect how uterine smooth muscle cells respond to growth signals from hormones and the environment. In PlexusDx context, the rs9344 genotype is interpreted as: AA (two effect alleles) = increased risk, AG (one effect allele) = likely increased risk, and GG (no effect alleles) = typical risk.

If I have the AA or AG genotype (effect alleles) for rs9344, what lifestyle steps may help?

Yes—genotype is not destiny. Regardless of whether you have AA, AG, or GG, lifestyle, diet, and environmental exposures can influence uterine health and may help reduce symptoms or slow fibroid growth. Common supportive steps include prioritizing a whole-food, mostly plant-forward diet rich in polyphenols (like berries, kale, beans, apples, cruciferous vegetables, onions, and garlic), limiting processed foods and added sugars, maintaining a healthy body weight, and staying physically active (aerobic plus resistance training).

How can I reduce endocrine disruptor exposure and when should I seek medical care for fibroid symptoms?

Because CCND1-related fibroid risk may involve sensitivity to hormonal and environmental triggers, reducing endocrine disrupting chemicals may be helpful. Practical measures include using glass or stainless steel food containers, avoiding heating food in plastic, and choosing personal care and household products labeled free of phthalates and made to reduce BPA exposure (including limiting BPA-lined canned foods). You should seek evaluation if you experience heavy or prolonged bleeding, severe pelvic pain, difficulty with fertility, or new/worsening pelvic symptoms; imaging and specialist referral may be appropriate based on symptoms.

What tests can help me learn more about Uterine Fibroids and CCND1 rs9344?

The Hormone, Thyroid, and Reproductive Health Genetic Test delivers over 85 personalized genetic insights through a comprehensive Hormone & Fertility Genetic Report, explaining inherited tendencies related to hormonal balance, reproductive function, and endocrine signaling. The Womens Hormone and Fertility Health Genetic Report translates your results into personalized, actionable guidance. Your healthcare provider can also recommend targeted blood tests based on your specific pathway results and health history to complement your genetic insights with current biomarker data.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.