Uterine Fibroids | CCND1 (rs9344)

If you have the AA genotype for rs9344, you carry two copies of the effect allele. This genotype is associated with a higher likelihood of developing uterine fibroids. The CCND1 variant linked to AA may increase cell growth signaling in uterine tissue, making uterine smooth muscle cells more responsive to hormonal and environmental triggers.

Lifestyle and dietary suggestions

• Prioritize a whole foods diet rich in fruits, vegetables, legumes, whole grains, nuts, and seeds.
• Emphasize polyphenol-rich foods such as berries, kale, beans, apples, and green tea. Polyphenols can modulate inflammation and cellular signaling.
• Limit intake of processed foods, high-sugar products, and excessive red or processed meats.
• Reduce or moderate soy and dairy if you notice symptom changes after consumption, and discuss alternatives with your clinician.
• Maintain a healthy body weight through balanced nutrition and portion control. Adipose tissue affects hormone levels and inflammation.

Supplements and botanicals to discuss with your provider

• Green tea extract standardized for EGCG
• Curcumin or turmeric formulations with enhanced absorption
• Resveratrol
• Ensure any supplement choice is safe in the context of your medications and health history.

Environmental and lifestyle measures

• Limit exposure to endocrine disrupting chemicals such as BPA and phthalates. Use glass or stainless steel food containers and choose personal care products labeled free of phthalates.
• Engage in regular physical activity, including aerobic exercise and resistance training, to support hormonal balance.
• Aim for 7 to 9 hours of sleep per night and manage stress with evidence based techniques such as mindfulness, yoga, or counseling.

Talk with your healthcare provider about personalized monitoring and symptom management. If fibroid symptoms appear or worsen, imaging and specialist referral may be appropriate.

If you have the AG genotype for rs9344, you carry one copy of the effect allele. This genotype is associated with a likely increased risk of developing uterine fibroids. The CCND1 variant may make uterine smooth muscle cells somewhat more sensitive to hormonal and environmental factors that promote growth.

Practical steps to support uterine health

• Follow a mostly plant forward diet emphasizing polyphenol rich foods: berries, dark leafy greens like kale, beans, cruciferous vegetables, onions, and garlic.
• Limit processed and fried foods, and reduce added sugars and refined carbohydrates.
• Consider moderating soy and dairy if you are concerned about symptom triggers.
• Maintain regular exercise and aim for a healthy body composition.

Supplements to consider with medical guidance

• Green tea extract (EGCG)
• Curcumin
• Resveratrol

Environmental and prevention tips

• Choose low chemical personal care and household products to reduce endocrine disruptor exposure.
• Avoid heating food in plastic, and limit canned foods that may be lined with BPA containing materials.
• Keep routine gynecologic care and discuss any menstrual changes, pelvic pain, or fertility concerns with your provider promptly.

Work with your clinician to create a monitoring plan. Early recognition of symptoms can support timely management and preserve reproductive health.

If you have the GG genotype for rs9344, you carry two copies of the non effect allele and do not have the CCND1 variation associated with increased cell cycle activity in uterine smooth muscle. Your genetic risk for fibroids is considered typical. That does not mean fibroids cannot occur. Lifestyle and environmental factors still play a significant role.

Recommendations for ongoing uterine health

• Maintain a balanced diet rich in whole foods, fruits, vegetables, legumes, and whole grains.
• Include polyphenol rich foods like berries, kale, beans, and green tea as part of a varied diet.
• Limit processed foods and reduce exposure to endocrine disruptors such as BPA and phthalates.
• Stay active with regular aerobic exercise and strength training, and manage stress and sleep quality.

When to seek care

• Seek evaluation for heavy or prolonged bleeding, severe pelvic pain, difficulty with fertility, or any new pelvic symptoms.
• Routine gynecologic exams and appropriate imaging based on symptoms help identify fibroids early when intervention may be helpful.