HSA | FSA CARDS ARE NOW ACCEPTED

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

ANRIL and Pregnancy: What Your rs1333048 Genotype Means for Vascular Health and Preeclampsia Risk

Pregnancy triggers major changes in blood vessels, blood pressure, and immune function to support the growing baby. The ANRIL gene produces a regulatory RNA that helps control vascular health and immune responses. Variants at the rs1333048 position in ANRIL are associated with differences in how the cardiovascular system adapts during pregnancy, which can influence the risk of preeclampsia — a condition marked by new-onset high blood pressure and potential damage to organs and the placenta.

How ANRIL Influences Pregnancy

ANRIL affects gene networks involved in vascular tone, inflammation, and blood vessel remodeling. During pregnancy, these processes determine how well the placenta is supplied with blood and how maternal blood pressure is regulated. Depending on which alleles you carry at rs1333048, your genetic profile may modestly shift your baseline risk for hypertensive complications in pregnancy, including preeclampsia, placental blood flow problems, growth restriction, and preterm birth.

Genetic Interpretations

Two effect alleles — CC genotype

If you have the CC genotype for rs1333048, you carry two copies of the effect allele. This genotype is associated with a lower risk of preeclampsia. The CC genotype is linked to improved vascular flexibility and more stable blood pressure regulation during pregnancy, which may help protect against complications such as reduced placental blood flow, fetal growth restriction, or preterm birth related to hypertensive disease.

Even with a protective genotype, maintaining healthy habits optimizes outcomes. Continue routine prenatal care and blood pressure monitoring, and follow the lifestyle and supplement guidance below to support vascular and placental health throughout pregnancy.

One effect allele — AC genotype

If you have the AC genotype for rs1333048, you carry one copy of the effect allele. This genotype is associated with a likely lower risk of preeclampsia compared with individuals who do not carry the C allele. The presence of a single C allele is linked to better-regulated blood pressure, improved placental blood flow, and reduced likelihood of growth restriction or preterm birth related to hypertensive complications.

This genetic advantage can be supported through regular prenatal monitoring and the dietary, supplement, and lifestyle strategies outlined below to help maintain healthy vascular function throughout pregnancy.

No effect alleles — AA genotype

If you have the AA genotype for rs1333048, you carry two copies of the non-effect allele. This genotype does not convey the same genetic protection linked to the C allele, and your baseline risk for preeclampsia is typical for the general population. Genetics is only one piece of the puzzle; many modifiable factors strongly influence pregnancy outcomes.

You can still reduce risk and support a healthy pregnancy by following evidence-informed nutrition, supplementation, monitoring, and lifestyle practices described below. Work with your healthcare provider to tailor a plan to your personal and pregnancy health history.

Dietary and Nutrition Recommendations

  • Adopt a heart-healthy pregnancy diet centered on vegetables, fruits, whole grains, lean proteins, beans, nuts, and seeds. Prioritize a variety of colors to ensure micronutrient diversity.
  • Limit sodium intake by minimizing processed foods, ready-made meals, and added salt. Aim to meet your provider's guidance for sodium during pregnancy.
  • Include folate-rich foods such as dark leafy greens, legumes, fortified cereals, and citrus. Adequate folate supports placental development and reduces the risk of neural tube defects.
  • Choose sources of lean protein and omega-3 fats: fatty fish low in mercury (for example, salmon and sardines), plant-based omega-3s (flax, chia, walnuts), and lean poultry.
  • Maintain regular, balanced meals and moderate portion sizes to support healthy weight gain and stable blood sugar.

Supplement Considerations

  • Take a prenatal vitamin that provides at least 400–800 micrograms of folic acid or methylfolate as recommended by your provider.
  • Ensure adequate vitamin D status through prenatal supplements and testing when indicated. Vitamin D supports immune and vascular health in pregnancy.
  • Consider supplemental magnesium if recommended by your healthcare provider; magnesium can support vascular tone and may help with blood pressure regulation.
  • Include omega-3 fatty acids (DHA/EPA) through prenatal formulations or doctor-approved fish oil to support fetal brain development and vascular health.
  • Always review supplements with your prenatal care provider before starting, stopping, or changing doses.

Lifestyle and Monitoring

  • Attend regular prenatal visits and blood pressure checks. Early detection of elevated blood pressure allows timely management.
  • Engage in gentle, pregnancy-appropriate physical activity such as walking, swimming, or prenatal yoga unless restricted by your provider.
  • Prioritize sleep, stress reduction, and mental health. Practices such as deep breathing, mindfulness, and prenatal support groups can be helpful.
  • Avoid tobacco, vaping, and alcohol. These exposures increase the risk of hypertensive disorders, placental problems, and adverse fetal outcomes.
  • Report symptoms promptly: severe headaches, visual changes, sudden swelling, upper abdominal pain, or decreased fetal movement require immediate clinical attention.

Blood Tests and Clinical Follow-Up

  • Routine prenatal labs and blood pressure monitoring are standard. Your provider may recommend additional testing based on personal or family history.
  • If you have risk factors for hypertensive disease, your provider may recommend more frequent monitoring, urine protein assessments, or specialized ultrasound evaluation of fetal growth and placental blood flow.
  • Work with your care team to interpret results in the context of your full medical history, medications, and pregnancy course.

When to Talk with Your Healthcare Provider

Share your genetic result with your prenatal provider so it can be considered alongside your medical history, blood pressure trends, and pregnancy course. Ask about personalized monitoring plans, whether additional labs or imaging are appropriate, and the best choices for supplements and activity in your specific case.

PlexusDx provides genetic information to educate about predispositions and potential risk patterns. This information is not medical advice. Always consult your healthcare provider or prenatal care team to make medical decisions, interpret test results, and design a care plan tailored to your health needs.

If this genetic variant is present in your PlexusDx results, the following tests and reports are commonly used to explore it further:

🧬 Genetic Tests:

🧪 Blood Tests:

📄 Genetic Report:

Frequently Asked Questions About Pregnancy and ANRIL rs1333048

What does the ANRIL rs1333048 genotype mean for preeclampsia risk?

The ANRIL gene produces a regulatory RNA involved in vascular health and immune responses during pregnancy. Variants at rs1333048 are associated with differences in how your cardiovascular system adapts during pregnancy, which can modestly shift your baseline risk for preeclampsia—a condition involving new-onset high blood pressure and potential organ/placental complications.

How do the rs1333048 CC, AC, and AA genotypes differ during pregnancy?

CC genotype: linked to a lower risk of preeclampsia and more stable blood pressure regulation, supporting protective placental blood flow and reduced risk of hypertensive-related growth restriction or preterm birth. AC genotype: carries one effect allele (C) and is associated with likely lower preeclampsia risk versus those without the C allele, with better-regulated blood pressure and improved placental blood flow. AA genotype: carries no C effect alleles; baseline preeclampsia risk is typical for the general population, so focus shifts to evidence-based nutrition, supplementation, monitoring, and lifestyle support.

What pregnancy nutrition, supplements, and monitoring can support vascular health if I have rs1333048 effects?

Support vascular and placental health with a heart-healthy pregnancy diet (vegetables, fruits, whole grains, lean proteins, beans, nuts, seeds) and by limiting sodium and processed foods. Aim for folate-rich foods, include lean protein and omega-3 sources (e.g., low-mercury fatty fish or doctor-approved omega-3s), and maintain regular balanced meals. Consider prenatal folic acid/methylfolate, vitamin D (based on testing/your provider’s guidance), magnesium if recommended, and DHA/EPA for fetal brain development and vascular support. Also attend routine prenatal visits with blood pressure checks, engage in pregnancy-appropriate gentle activity if cleared, avoid tobacco/vaping/alcohol, and report urgent symptoms (severe headaches, visual changes, sudden swelling, upper abdominal pain, or decreased fetal movement) promptly.

What tests can help me learn more about Pregnancy and ANRIL rs1333048?

The Hormone, Thyroid, and Reproductive Health Genetic Test delivers over 85 personalized genetic insights through a comprehensive Hormone & Fertility Genetic Report, explaining inherited tendencies related to hormonal balance, reproductive function, and endocrine signaling. The Womens Hormone and Fertility Health Genetic Report translates your results into personalized, actionable guidance. Your healthcare provider can also recommend targeted blood tests based on your specific pathway results and health history to complement your genetic insights with current biomarker data.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.