Weight Regain | ADRB2 (rs1042713)

If your genotype is GG you carry two copies of the effect allele. This is associated with reduced beta-2 receptor efficiency. Practically, this may mean:

• Slower fat breakdown when the body signals for energy release.
• A higher tendency to store fat after weight loss and a greater risk of weight regain.
• Possible need for stronger or more consistent lifestyle measures to maintain weight loss.

Practical recommendations

• Nutrition: Focus on high quality whole foods, moderate protein intake at each meal to support muscle mass, and healthy fats. Aim for a small sustainable calorie deficit or careful calorie maintenance to avoid metabolic slowdown.
• Exercise: Prioritize resistance training 2 to 4 times per week to preserve or build lean muscle, combined with regular cardiovascular activity to increase total energy expenditure.
• Meal timing and composition: Include protein and fiber at meals to support satiety. Consider higher protein during weight maintenance phases to protect lean mass.
• Behavior: Use consistent habits, tracking, and structured plans. Small, daily routines are more effective than sporadic intense efforts.
• Supplements to consider: Protein powder to help reach protein goals, vitamin D if deficient, omega 3 fatty acids for metabolic and inflammatory support. Discuss appropriateness with your healthcare provider.
• Monitoring: Regular body composition checks, not just scale weight, and periodic metabolic or hormone testing if recommended by your clinician.

If your genotype is AG you carry one effect allele. This is associated with a modest reduction in beta-2 receptor function. You may be somewhat more likely to regain weight after loss compared to individuals without the effect allele, but lifestyle can substantially offset this influence.

Practical recommendations

• Nutrition: Emphasize whole foods, adequate protein, and balanced meals with vegetables, whole grains or lower glycemic carbohydrates, and healthy fats. Avoid highly restrictive diets that are hard to sustain.
• Exercise: Combine regular aerobic exercise with strength training to maintain metabolic rate and preserve muscle after weight loss.
• Behavior: Build consistent, maintainable habits. Use portion awareness and mindful eating to prevent slow creep of calories.
• Supplements to consider: Protein supplementation if dietary intake is low, vitamin D if levels are low, and omega 3s if dietary fish intake is low. Review with your healthcare provider.
• Monitoring: Track progress with simple metrics like waist circumference, energy levels, and how clothes fit in addition to body weight.

If your genotype is AA you carry two copies of the non effect allele. This suggests typical beta-2 receptor function related to this specific variant. Your genetic profile for this variant does not indicate an increased predisposition to weight regain. Lifestyle and environment remain the most important factors.

Practical recommendations

• Nutrition: Continue with a balanced, whole foods based diet. Prioritize protein and fiber for satiety and muscle support.
• Exercise: Regular cardiovascular and resistance training will support long term weight stability and overall health.
• Behavior: Maintain consistent sleep, stress management, and daily activity patterns to reduce risk of weight drift over time.
• Supplements: Use targeted supplements only as needed based on diet and lab results, after discussing with your clinician.
• Monitoring: Regular check ins on weight and body composition help you catch small trends early and make adjustments.