HSA | FSA CARDS ARE NOW ACCEPTED

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

FN1 Gene and Stretch Marks: What Your Genotype Means for Skin Resilience

Stretch marks are common skin lines that appear when the skin stretches or shrinks quickly, causing tiny tears in collagen and elastin fibers. Fibronectin, a protein produced by the FN1 gene, helps support skin structure and guides tissue repair after these microscopic injuries. Variations in the FN1 gene can change fibronectin function, which may affect how well your skin repairs itself and how likely you are to develop stretch marks.

How fibronectin affects skin health

Fibronectin helps cells attach to the extracellular matrix, supports collagen and elastin organization, and signals wound-healing processes. If fibronectin production or function is reduced, the skin may be slower or less effective at repairing the small tears caused by rapid stretching. That can increase the visible risk of stretch marks during pregnancy, growth spurts, weight changes, or rapid muscle gain.

Simple strategies to support skin resilience

  • Nutrition: Aim for a balanced diet with adequate vitamin C, zinc, complete protein, and antioxidants to support collagen synthesis and tissue repair.
  • Hydration: Drink sufficient fluids daily to support skin hydration and elasticity.
  • Topical care: Regular moisturizing and gentle skin massage can improve skin pliability and circulation.
  • Targeted supplements: Collagen peptides and hyaluronic acid may support skin structure and hydration when used alongside a healthy diet.
  • Weight management: Avoid rapid weight gain or loss when possible; if changes are expected, increase skin-supportive care during those periods.

Genetic Interpretations

2 effect alleles (AA) — Higher risk

If you have the AA genotype for rs3910516, you carry two copies of the effect allele. This configuration is associated with a higher genetic risk for stretch marks due to potential reductions in fibronectin function. Your skin may be less efficient at repairing microscopic tears in collagen and elastin when stretched quickly. That means situations such as pregnancy, adolescent growth spurts, rapid weight gain, or fast muscle growth may more often lead to visible stretch marks.

Practical steps:

  • Increase intake of vitamin C rich foods (citrus, strawberries, bell peppers) to support collagen production.
  • Include zinc sources (shellfish, lean meats, legumes, seeds) for tissue repair.
  • Prioritize high-quality protein (fish, poultry, eggs, dairy, or plant-based complete proteins) to supply amino acids for collagen and fibronectin synthesis.
  • Consider collagen peptide supplements daily to provide building blocks for extracellular matrix proteins.
  • Add hyaluronic acid support for skin hydration, taken orally or used topically.
  • Use emollient moisturizers twice daily and add gentle skin massage to increase local circulation and elasticity.
  • Monitor body changes and work with a healthcare provider to plan slower, steady weight or muscle gains when possible.
1 effect allele (AG) — Moderate risk

If you have the AG genotype for rs3910516, you carry one copy of the effect allele. This is associated with a moderate increase in risk for stretch marks compared with people who carry no effect alleles. Your fibronectin production is likely close to typical levels but may be somewhat affected, so your skin repair ability could be mildly reduced under stress.

Practical steps:

  • Ensure consistent vitamin C intake to support collagen formation, including foods and, if needed, a daily supplement within recommended amounts.
  • Eat a balanced diet rich in complete proteins and zinc to support tissue repair.
  • Maintain good skin hydration and add regular moisturization, especially during periods of rapid body change.
  • Consider collagen peptides or topical hyaluronic acid if you notice early signs of skin fragility.
  • Adopt gradual approaches to weight or muscle changes to reduce mechanical stress on skin.
0 effect alleles (GG) — Typical risk

If you have the GG genotype for rs3910516, you carry two copies of the non-effect allele. This pattern is associated with typical fibronectin production and average wound-repair capability for skin. While your genetic predisposition for stretch marks is average, stretch marks can still occur from pregnancy, growth spurts, or rapid weight changes.

Practical steps:

  • Maintain a nutrient-dense diet with vitamin C, zinc, and adequate protein to support ongoing skin health.
  • Keep skin well hydrated and use moisturizers regularly, especially during known periods of rapid body change.
  • Consider preventive topical care and gentle massage during pregnancy or athletic training phases.
  • Monitor skin for early lines and respond with increased hydration and care to reduce progression.

Diet recommendations

  • Vitamin C: Citrus fruits, berries, kiwi, bell peppers, broccoli. Vitamin C is required for collagen cross-linking and fibronectin-related repair.
  • Zinc: Oysters, beef, pumpkin seeds, lentils. Zinc supports cell division and tissue repair.
  • Protein: Lean meats, fish, dairy, eggs, soy, legumes, and varied plant proteins provide the amino acids needed for collagen and extracellular matrix proteins.
  • Antioxidants: Colorful fruits and vegetables, green tea, and nuts help reduce oxidative stress that can weaken skin structure.

Supplements and topical supports

  • Collagen peptides: Provide amino acids for matrix repair; commonly used daily in powder or capsule form.
  • Hyaluronic acid: Supports skin hydration and can be taken orally or applied topically.
  • Vitamin C supplement: Useful if dietary intake is insufficient; follow recommended dosing guidance.
  • Moisturizers with emollients and humectants: Apply daily to maintain skin elasticity and reduce tearing risk.

Lifestyle tips

  • Hydrate consistently throughout the day.
  • Aim for gradual weight gain or loss when possible to reduce mechanical stress on skin.
  • Incorporate strength training gradually during muscle-building phases to avoid overly rapid increases in skin stretch.
  • Use gentle exfoliation and massage to support circulation and topical absorption of moisturizers.
  • Protect skin from excessive sun exposure to preserve collagen integrity.

When to consider clinical input or testing

  • Rapid, unexplained skin changes or widespread stretch marks without clear cause—speak with your healthcare provider.
  • Planning pregnancy or major body changes—discuss preventive skin-care plans with a clinician or dermatologist.
  • Considering high-dose supplements or treatments—review with a healthcare provider to ensure safety and interactions with medications or conditions.

Important notice

PlexusDx does not provide medical advice. This content is educational and describes genetic predispositions only. Always consult your healthcare provider before making changes to your diet, supplement routine, or medical care.

If this genetic variant is present in your PlexusDx results, the following tests and reports are commonly used to explore it further:

🧬 Genetic Tests:

🧪 Blood Tests:

📄 Genetic Report:

Frequently Asked Questions About Stretch Marks and FN1 rs3910516

How does the FN1 rs3910516 genotype affect my risk of stretch marks?

FN1 helps produce fibronectin, which supports skin structure and guides repair after tiny collagen and elastin injuries from rapid stretching. With rs3910516, having 2 effect alleles (AA) is linked to higher stretch mark risk, having 1 effect allele (AG) is linked to moderate risk, and having 0 effect alleles (GG) is linked to typical risk—though stretch marks can still happen with pregnancy, growth spurts, or rapid weight changes.

Why is fibronectin important for skin resilience during pregnancy or growth spurts?

Fibronectin helps cells attach to the extracellular matrix, supports organized collagen and elastin, and signals wound-healing. If fibronectin production or function is reduced, your skin may repair the micro-tears caused by quick body changes less efficiently, which can increase the visible likelihood of stretch marks during pregnancy, adolescence, weight shifts, or fast muscle gain.

What skin-supportive strategies can help regardless of my rs3910516 genotype?

To support collagen and tissue repair, focus on vitamin C, zinc, complete protein, antioxidants, and stay well hydrated. Pair this with regular moisturizing and gentle massage to improve skin pliability, and consider collagen peptides and/or hyaluronic acid (topical or oral) alongside a nutrient-dense routine. If possible, aim for gradual weight or muscle changes and consider clinical input before starting high-dose supplements or if you experience rapid, unexplained skin changes.

What tests can help me learn more about Stretch Marks and FN1 rs3910516?

The Longevity and Healthy Aging Genetic Test delivers over 200 genetic insights related to cellular repair, inflammation balance, metabolism, cardiometabolic health, and aging pathways. The Healthy Aging Genetic Report translates your results into personalized, actionable guidance. Your healthcare provider can also recommend targeted blood tests based on your specific pathway results and health history to complement your genetic insights with current biomarker data.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.