HSA | FSA CARDS ARE NOW ACCEPTED

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

TNFRSF1A and Inflammation: What Your rs767455 Genotype Means for Healthy Aging

Inflammation is the body’s natural response to injury or infection. Short-term inflammation helps heal and protect tissues. When inflammation becomes chronic, it can contribute to age-related diseases such as heart disease, type 2 diabetes, and neurodegenerative conditions. The TNFRSF1A gene makes the TNF Receptor 1 protein, which senses inflammatory signals from TNF-alpha and helps regulate immune responses. Variations in this gene can change how inflammation is managed, which may influence your risk for inflammatory conditions. No genotype guarantees a condition will or will not develop; genes interact with lifestyle and environment.

How to Think About Genetic Risk

  • Genetic variation can change how strongly or weakly cells respond to inflammatory signals.
  • Healthy lifestyle choices often have larger effects on long-term inflammation than single gene variants.
  • Use genetic information as a guide to personalization, not as a diagnosis.
Two effect alleles (CC) — Increased risk of inflammatory dysregulation

You carry two copies of the effect allele at rs767455 (CC). This genotype is associated with a higher likelihood of altered TNF Receptor 1 function and an increased risk of inflammatory diseases. That could mean a stronger or less well-regulated response to inflammatory signals. Carrying this genotype does not mean you will develop disease. It means paying attention to inflammation-related health measures may be especially helpful.

Practical recommendations

  • Diet: Emphasize a Mediterranean-style pattern — vegetables, fruits, whole grains, legumes, lean proteins (fish, poultry), nuts, and olive oil. Limit processed foods, refined carbs, and trans fats.
  • Omega-3s: Consider EPA/DHA from fatty fish or a high-quality fish oil supplement after consulting your healthcare provider.
  • Anti-inflammatory herbs: Turmeric (curcumin) and ginger may help reduce inflammation for some people; discuss dosing and interactions with a clinician.
  • Weight: Maintain a healthy body weight; excess adiposity increases systemic inflammation.
  • Exercise: Aim for at least 150 minutes per week of moderate aerobic activity plus two sessions of resistance training.
  • Sleep: Target 7 to 9 hours of quality sleep per night. Poor sleep raises inflammatory markers.
  • Stress: Use stress reduction practices such as mindfulness, cognitive-behavioral strategies, yoga, or breathing techniques to lower chronic stress-driven inflammation.
  • Monitoring: Talk to your clinician about periodic checks of inflammatory markers (for example, high-sensitivity CRP), metabolic health, and cardiovascular risk assessment if clinically indicated.
  • Medication considerations: Some people with inflammatory conditions require medical therapies guided by a specialist. Genetics can inform monitoring but not replace medical management.
One effect allele (CT) — Likely modestly increased risk

You have one copy of the effect allele at rs767455 (CT). This genotype is associated with a likely increased tendency toward a stronger or somewhat altered inflammatory response. The effect is generally less pronounced than with two effect alleles. Lifestyle interventions that reduce chronic inflammation can be especially valuable.

Practical recommendations

  • Diet: Focus on whole, minimally processed foods. Prioritize plant-based meals, oily fish twice weekly, and replace refined grains with whole grains.
  • Omega-3s and polyphenols: Include fatty fish, walnuts, chia or flax seeds, and colorful produce rich in polyphenols. Supplements can be considered after medical discussion.
  • Physical activity: Regular aerobic and strength training helps lower systemic inflammation and improves metabolic health.
  • Sleep and stress: Prioritize consistent sleep routines and stress management to reduce inflammatory signaling.
  • Body composition: Prevent central adiposity through diet and exercise; abdominal fat is a major source of inflammatory molecules.
  • Routine care: Maintain preventive health visits and appropriate screening for cardiovascular and metabolic risk.
No effect alleles (TT) — Typical inflammatory regulation

You carry two copies of the non-effect allele at rs767455 (TT). This is the most common genotype and is associated with typical TNF Receptor 1 function and ordinary inflammatory regulation. Even with this genotype, chronic inflammation can arise from lifestyle and environmental factors, so prevention remains important.

Practical recommendations

  • Diet: Maintain an anti-inflammatory eating pattern rich in fruits, vegetables, whole grains, legumes, lean proteins, and healthy fats.
  • Exercise: Continue regular physical activity and strength training to support immune and metabolic health.
  • Sleep and stress: Sustain healthy sleep habits and effective stress reduction strategies to minimize inflammation over the long term.
  • Preventive screening: Follow routine health checkups and screenings as advised by your healthcare provider.

Practical Lifestyle and Nutrition Strategies to Support Healthy Inflammation

  • Adopt a Mediterranean-style or whole-foods dietary pattern emphasizing fiber, monounsaturated fats, omega-3 fatty acids, and phytonutrients.
  • Include fatty fish (salmon, sardines, mackerel) 2 to 3 times per week or discuss omega-3 supplements with your clinician.
  • Use culinary turmeric and ginger regularly; consider a standardized curcumin supplement only after consulting a healthcare provider for dosing and safety.
  • Limit added sugars, processed meats, ultra-processed snacks, and excessive alcohol intake.
  • Engage in regular physical activity combining aerobic and resistance training; break up long sedentary periods.
  • Prioritize sleep hygiene: consistent schedule, dark and cool bedroom, limited screens before bed.
  • Use stress reduction techniques daily: meditation, paced breathing, spending time outdoors, or structured therapy when needed.
  • Maintain healthy body composition through balanced energy intake and activity.

Supplement and Testing Considerations

  • Supplements to consider with clinical guidance: EPA/DHA fish oil, vitamin D if deficient, and standardized curcumin for targeted use.
  • Before starting supplements, review potential interactions with medications and underlying conditions with your clinician.
  • Tests your clinician may consider based on symptoms or risk: high-sensitivity C-reactive protein (hs-CRP), fasting glucose and lipids, HbA1c, vitamin D level, and other inflammatory markers as clinically indicated.

When to Seek Medical Attention

  • If you experience unexplained fevers, persistent joint pain, rash, significant fatigue, or other concerning symptoms, consult your healthcare provider.
  • If you have a personal or family history of autoimmune or autoinflammatory disease, consider discussing referral to a rheumatologist or immunologist.

Important Disclaimer

PlexusDx provides educational information about genetic predispositions only. This content is not medical advice and should not replace care from a qualified healthcare professional. Always consult your healthcare provider before making changes to diet, supplements, medications, or lifestyle based on genetic results.

If this genetic variant is present in your PlexusDx results, the following tests and reports are commonly used to explore it further:

🧬 Genetic Tests:

🧪 Blood Tests:

📄 Genetic Report:

Frequently Asked Questions About INFLAMMATION and TNFRSF1A rs767455

What does the TNFRSF1A rs767455 (CC, CT, or TT) genotype mean for inflammation?

TNFRSF1A helps control signaling through TNF Receptor 1, which responds to inflammatory signals from TNF-alpha. The rs767455 genotype can be associated with differences in how strongly or how well inflammation is regulated. CC (two effect alleles) is associated with increased likelihood of altered TNF Receptor 1 function and a higher risk of inflammatory dysregulation; CT (one effect allele) is generally linked to a modestly increased tendency toward a stronger or altered inflammatory response; TT (no effect alleles) is associated with typical inflammatory regulation.

How should I adjust my lifestyle if my rs767455 results show CC or CT?

Even if you carry an effect allele, genes do not guarantee disease—lifestyle and environment strongly influence long-term inflammation. For CC and CT, the source recommends prioritizing an anti-inflammatory, whole-foods or Mediterranean-style dietary pattern (including fruits, vegetables, whole grains, legumes, lean proteins, and olive oil), omega-3 sources (fatty fish or clinician-guided fish oil), regular aerobic plus resistance exercise (about 150 minutes/week of moderate activity plus strength training), 7–9 hours of quality sleep, and daily stress-reduction strategies (mindfulness, breathing, yoga, or therapy when needed). Maintaining a healthy weight and discussing appropriate inflammatory-marker monitoring with your clinician can also be especially useful.

What inflammatory tests might a clinician consider for people with rs767455 risk-associated genotypes?

Testing depends on symptoms and overall risk, but the source notes that clinicians may consider high-sensitivity C-reactive protein (hs-CRP) and metabolic/inflammation-related labs such as fasting glucose and lipids, HbA1c, vitamin D levels, and other inflammatory markers as clinically indicated. If you have concerning symptoms (e.g., unexplained fevers, persistent joint pain, rash, or significant fatigue) or a personal/family history of autoimmune or autoinflammatory disease, seek medical attention and discuss whether referral to a rheumatologist or immunologist is appropriate.

What tests can help me learn more about INFLAMMATION and TNFRSF1A rs767455?

The Longevity and Healthy Aging Genetic Test delivers over 200 genetic insights related to cellular repair, inflammation balance, metabolism, cardiometabolic health, and aging pathways. The Healthy Aging Genetic Report translates your results into personalized, actionable guidance. Your healthcare provider can also recommend targeted blood tests based on your specific pathway results and health history to complement your genetic insights with current biomarker data.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.