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TNFRSF1A and Inflammation: What Your rs767455 Genotype Means for Healthy Aging

Inflammation is the body’s natural response to injury or infection. Short-term inflammation helps heal and protect tissues. When inflammation becomes chronic, it can contribute to age-related diseases such as heart disease, type 2 diabetes, and neurodegenerative conditions. The TNFRSF1A gene makes the TNF Receptor 1 protein, which senses inflammatory signals from TNF-alpha and helps regulate immune responses. Variations in this gene can change how inflammation is managed, which may influence your risk for inflammatory conditions. No genotype guarantees a condition will or will not develop; genes interact with lifestyle and environment.

How to Think About Genetic Risk

  • Genetic variation can change how strongly or weakly cells respond to inflammatory signals.
  • Healthy lifestyle choices often have larger effects on long-term inflammation than single gene variants.
  • Use genetic information as a guide to personalization, not as a diagnosis.
Two effect alleles (CC) — Increased risk of inflammatory dysregulation

You carry two copies of the effect allele at rs767455 (CC). This genotype is associated with a higher likelihood of altered TNF Receptor 1 function and an increased risk of inflammatory diseases. That could mean a stronger or less well-regulated response to inflammatory signals. Carrying this genotype does not mean you will develop disease. It means paying attention to inflammation-related health measures may be especially helpful.

Practical recommendations

  • Diet: Emphasize a Mediterranean-style pattern — vegetables, fruits, whole grains, legumes, lean proteins (fish, poultry), nuts, and olive oil. Limit processed foods, refined carbs, and trans fats.
  • Omega-3s: Consider EPA/DHA from fatty fish or a high-quality fish oil supplement after consulting your healthcare provider.
  • Anti-inflammatory herbs: Turmeric (curcumin) and ginger may help reduce inflammation for some people; discuss dosing and interactions with a clinician.
  • Weight: Maintain a healthy body weight; excess adiposity increases systemic inflammation.
  • Exercise: Aim for at least 150 minutes per week of moderate aerobic activity plus two sessions of resistance training.
  • Sleep: Target 7 to 9 hours of quality sleep per night. Poor sleep raises inflammatory markers.
  • Stress: Use stress reduction practices such as mindfulness, cognitive-behavioral strategies, yoga, or breathing techniques to lower chronic stress-driven inflammation.
  • Monitoring: Talk to your clinician about periodic checks of inflammatory markers (for example, high-sensitivity CRP), metabolic health, and cardiovascular risk assessment if clinically indicated.
  • Medication considerations: Some people with inflammatory conditions require medical therapies guided by a specialist. Genetics can inform monitoring but not replace medical management.
One effect allele (CT) — Likely modestly increased risk

You have one copy of the effect allele at rs767455 (CT). This genotype is associated with a likely increased tendency toward a stronger or somewhat altered inflammatory response. The effect is generally less pronounced than with two effect alleles. Lifestyle interventions that reduce chronic inflammation can be especially valuable.

Practical recommendations

  • Diet: Focus on whole, minimally processed foods. Prioritize plant-based meals, oily fish twice weekly, and replace refined grains with whole grains.
  • Omega-3s and polyphenols: Include fatty fish, walnuts, chia or flax seeds, and colorful produce rich in polyphenols. Supplements can be considered after medical discussion.
  • Physical activity: Regular aerobic and strength training helps lower systemic inflammation and improves metabolic health.
  • Sleep and stress: Prioritize consistent sleep routines and stress management to reduce inflammatory signaling.
  • Body composition: Prevent central adiposity through diet and exercise; abdominal fat is a major source of inflammatory molecules.
  • Routine care: Maintain preventive health visits and appropriate screening for cardiovascular and metabolic risk.
No effect alleles (TT) — Typical inflammatory regulation

You carry two copies of the non-effect allele at rs767455 (TT). This is the most common genotype and is associated with typical TNF Receptor 1 function and ordinary inflammatory regulation. Even with this genotype, chronic inflammation can arise from lifestyle and environmental factors, so prevention remains important.

Practical recommendations

  • Diet: Maintain an anti-inflammatory eating pattern rich in fruits, vegetables, whole grains, legumes, lean proteins, and healthy fats.
  • Exercise: Continue regular physical activity and strength training to support immune and metabolic health.
  • Sleep and stress: Sustain healthy sleep habits and effective stress reduction strategies to minimize inflammation over the long term.
  • Preventive screening: Follow routine health checkups and screenings as advised by your healthcare provider.

Practical Lifestyle and Nutrition Strategies to Support Healthy Inflammation

  • Adopt a Mediterranean-style or whole-foods dietary pattern emphasizing fiber, monounsaturated fats, omega-3 fatty acids, and phytonutrients.
  • Include fatty fish (salmon, sardines, mackerel) 2 to 3 times per week or discuss omega-3 supplements with your clinician.
  • Use culinary turmeric and ginger regularly; consider a standardized curcumin supplement only after consulting a healthcare provider for dosing and safety.
  • Limit added sugars, processed meats, ultra-processed snacks, and excessive alcohol intake.
  • Engage in regular physical activity combining aerobic and resistance training; break up long sedentary periods.
  • Prioritize sleep hygiene: consistent schedule, dark and cool bedroom, limited screens before bed.
  • Use stress reduction techniques daily: meditation, paced breathing, spending time outdoors, or structured therapy when needed.
  • Maintain healthy body composition through balanced energy intake and activity.

Supplement and Testing Considerations

  • Supplements to consider with clinical guidance: EPA/DHA fish oil, vitamin D if deficient, and standardized curcumin for targeted use.
  • Before starting supplements, review potential interactions with medications and underlying conditions with your clinician.
  • Tests your clinician may consider based on symptoms or risk: high-sensitivity C-reactive protein (hs-CRP), fasting glucose and lipids, HbA1c, vitamin D level, and other inflammatory markers as clinically indicated.

When to Seek Medical Attention

  • If you experience unexplained fevers, persistent joint pain, rash, significant fatigue, or other concerning symptoms, consult your healthcare provider.
  • If you have a personal or family history of autoimmune or autoinflammatory disease, consider discussing referral to a rheumatologist or immunologist.

Important Disclaimer

PlexusDx provides educational information about genetic predispositions only. This content is not medical advice and should not replace care from a qualified healthcare professional. Always consult your healthcare provider before making changes to diet, supplements, medications, or lifestyle based on genetic results.