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Riboflavin, FMO3, and What Your Genotype Means for Energy and Cardiovascular Health

Riboflavin, also known as Vitamin B2, is a water soluble vitamin that plays a central role in converting food into usable energy. It supports cell growth, helps the body absorb iron, and contributes to antioxidant defenses that protect cells from damage. The FMO3 gene encodes an enzyme in the liver that helps break down certain dietary compounds, including converting trimethylamine or TMA into a non-odorous form. This enzyme depends on coenzymes derived from riboflavin to function well.

Variants in the FMO3 gene can change how efficiently this enzyme works. Reduced FMO3 activity can mean slower processing of some dietary compounds and may be associated with higher risk for certain health issues, including elevated blood pressure under particular circumstances. Lifestyle factors such as smoking can interact with genetic variation to increase those risks. The guidance below explains the common genotypes at rs2266782, what they usually mean for FMO3 function, and practical steps you can take to support healthy metabolism and cardiovascular wellness.

Genetic interpretations

AA genotype (2 effect alleles): decreased FMO3 function

If your genotype at rs2266782 is AA, you carry two copies of the effect allele. This is associated with decreased FMO3 enzyme function. Because FMO3 depends on riboflavin derived coenzymes, lower enzyme activity may reduce the efficiency of breaking down compounds such as trimethylamine from dietary sources.

Health considerations

  • Potential for slower clearance of certain dietary compounds.
  • Possible increased risk of elevated blood pressure, particularly among people who smoke.
  • Riboflavin status may be especially important to support residual enzyme activity.

Practical steps

  • Prioritize riboflavin rich foods: dairy, eggs, lean meats, fortified grains, spinach, and leafy vegetables.
  • Discuss riboflavin supplementation with your healthcare provider if dietary intake may be insufficient.
  • Avoid smoking and limit other exposures that can worsen cardiovascular risk.
  • Maintain regular physical activity and follow a balanced diet to support blood pressure and metabolic health.
AG genotype (1 effect allele): slightly decreased FMO3 function

If your genotype at rs2266782 is AG, you carry one copy of the effect allele. This is associated with a modest reduction in FMO3 enzyme function. The enzyme still functions, but slightly less efficiently compared to the typical form.

Health considerations

  • Slightly reduced efficiency in processing some dietary compounds.
  • Small increase in risk for elevated blood pressure has been reported among smokers with this variant.

Practical steps

  • Include riboflavin rich foods regularly: dairy products, eggs, lean meats, fortified grains, mushrooms, and almonds.
  • Consider supplementation only after consulting your healthcare provider, especially if you follow a restrictive diet.
  • Avoid smoking and reduce exposure to secondhand smoke.
  • Adopt heart healthy habits: regular exercise, stress management, and a diet rich in fruits, vegetables, whole grains, and lean protein.
GG genotype (0 effect alleles): typical FMO3 function

If your genotype at rs2266782 is GG, you carry two copies of the non-effect allele. This is associated with typical FMO3 enzyme function. Your FMO3 enzyme is expected to work efficiently, relying on riboflavin derived coenzymes to break down compounds like trimethylamine.

Health considerations

  • No genetic decrease in FMO3 function is expected based on this variant.
  • Maintaining adequate riboflavin intake remains important for energy production, iron metabolism, and cellular protection.

Practical steps

  • Consume riboflavin rich foods: dairy, eggs, lean meats, fortified grains, mushrooms, spinach, and almonds.
  • Keep a balanced lifestyle with regular exercise and avoid smoking to support cardiovascular health.
  • Consider routine nutrition review with your healthcare provider if you have additional health concerns.

Dietary recommendations

Focus on whole foods that are naturally high in riboflavin and supportive nutrients. Examples to include regularly:

  • Dairy: milk, yogurt, cheese
  • Eggs
  • Lean meats and poultry
  • Fortified cereals and whole grain products
  • Leafy greens such as spinach
  • Mushrooms and almonds

A varied diet will also provide other B vitamins, antioxidants, and minerals that support liver function and cardiovascular health.

Supplement considerations

Many people meet riboflavin needs through food, but supplements can be helpful in certain situations, such as restrictive diets, increased needs, or documented deficiency. Typical supplemental options include B complex vitamins or single riboflavin supplements. Discuss dose, timing, and potential interactions with your healthcare provider before starting any new supplement.

Lifestyle strategies to support FMO3 and cardiovascular health

  • Avoid tobacco use and limit exposure to secondhand smoke. Smoking may amplify the effect of reduced FMO3 function on blood pressure.
  • Engage in regular moderate physical activity. Aim for a mix of aerobic and strength training exercises most days of the week.
  • Manage stress through sleep, mindfulness, or other techniques that work for you.
  • Maintain a balanced weight and monitor blood pressure regularly, especially if you have additional risk factors.

Testing and follow up

If you are concerned about riboflavin status or cardiovascular risk, your healthcare provider can order nutritional assessments and screening tests such as blood pressure monitoring and routine labs. If supplementation is being considered, your provider can recommend appropriate dosing and monitor for effectiveness.

Limitations and next steps

Genetic information describes predispositions and tendencies, not certainties. The rs2266782 variant relates to FMO3 enzyme efficiency but does not diagnose specific conditions on its own. Environment, diet, lifestyle, and other genes also influence outcomes.

Important notice

PlexusDx provides educational information about genetic predispositions only. This content is not medical advice. Always consult your healthcare provider before making medical decisions, starting supplements, or changing lifestyle and treatment plans.