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Understanding Your Magnesium Genetics: ATP2B1 and rs7965584

Magnesium is an essential mineral involved in more than 300 enzyme reactions that support muscle and nerve function, blood sugar control, blood pressure regulation, energy production, and bone health. Most magnesium is stored in bones and tissues, with a small amount circulating in the blood. The ATP2B1 gene produces an enzyme that helps regulate calcium transport and may also influence how the body maintains magnesium balance in the blood. Variations at the rs7965584 location can be associated with differences in serum magnesium levels.

How to Read This Result

This report explains how your rs7965584 genotype in ATP2B1 relates to magnesium balance and offers practical, consumer-friendly tips on diet, supplements, lifestyle, and monitoring. Genetic predisposition is one factor among many. Environment, diet, medications, and health conditions also affect magnesium status. PlexusDx does not provide medical advice. Always consult your healthcare provider before making changes to supplements, medications, or treatment plans.

Quick Summary

  • Magnesium supports muscle, nerve, cardiovascular, metabolic, and bone health.
  • ATP2B1 plays a role in mineral transport; rs7965584 genotypes can influence serum magnesium.
  • Dietary and lifestyle strategies can help support healthy magnesium levels regardless of genotype.
  • Discuss testing and supplementation with your healthcare provider before starting new treatments.

Genetic Interpretations

2 effect alleles (GG) — Lower serum magnesium levels

If you have the GG genotype for rs7965584, you carry two copies of the effect allele. This genotype is associated with lower serum magnesium levels. While ATP2B1 primarily participates in calcium transport, research suggests it may also influence how the body maintains magnesium balance in blood.

Implications

  • Higher risk for lower circulating magnesium compared with people without the effect allele.
  • Potential impact on muscle and nerve function, energy metabolism, blood pressure regulation, and bone health if magnesium intake is inadequate.
  • May benefit from more proactive dietary and lifestyle measures and possibly supplementation under clinical guidance.

Practical steps are described in the diet, supplements, and lifestyle sections below.

1 effect allele (AG) — Likely lower serum magnesium levels

If you have the AG genotype for rs7965584, you carry one copy of the effect allele. This genotype is associated with likely lower serum magnesium levels. With one copy of the G allele, your body may be somewhat less efficient at maintaining optimal magnesium levels compared with people without the allele.

Implications

  • Moderate predisposition to lower circulating magnesium.
  • Consider emphasizing magnesium-rich foods and healthy habits to support normal levels.
  • Supplements such as magnesium citrate or glycinate may help when dietary intake is insufficient; check with your healthcare provider before starting.
0 effect alleles (AA) — Typical serum magnesium levels

If you have the AA genotype for rs7965584, you carry two copies of the non-effect allele. This genotype is associated with typical serum magnesium levels. Your genetic variation at this location does not predispose you to lower blood magnesium through this specific pathway.

Implications

  • No increased genetic risk for lower serum magnesium from rs7965584.
  • Standard dietary and lifestyle recommendations apply to maintain healthy magnesium status.
  • Continue routine monitoring and discuss any symptoms or concerns with your healthcare provider.

Diet Recommendations to Support Magnesium

Food is the best first-line source of magnesium. Aim for a varied diet that regularly includes magnesium-rich choices. Try to include several servings per week of the following:

  • Leafy greens: spinach, Swiss chard, kale
  • Nuts and seeds: almonds, cashews, pumpkin seeds, chia seeds
  • Legumes: black beans, lentils, chickpeas
  • Whole grains: brown rice, quinoa, oats
  • Fatty fish: salmon, mackerel
  • Avocado, bananas, dark chocolate (70 percent cocoa or higher)

Cooking tips: soak and rinse beans and whole grains to improve mineral availability. Favor whole foods over highly processed alternatives, which tend to be lower in magnesium.

Supplement Recommendations

If dietary intake is inadequate or blood tests show low magnesium, supplementation may be useful. Discuss supplementation with your healthcare provider to determine dose and form. Commonly used forms include:

  • Magnesium citrate: well absorbed, may have mild laxative effects in higher doses
  • Magnesium glycinate: well tolerated, less likely to cause loose stools
  • Magnesium oxide: higher elemental magnesium content but lower absorption; may cause more digestive side effects

General guidance

  • Your provider can recommend appropriate dosing based on lab results, symptoms, kidney function, and medications.
  • Avoid very high doses without medical supervision because excess magnesium can cause gastrointestinal symptoms and, in severe cases, affect heart rhythm, especially with impaired kidney function.

Lifestyle Strategies to Support Magnesium Balance

  • Manage stress: chronic stress can increase magnesium loss. Practices such as mindfulness, deep breathing, yoga, or regular gentle movement can help.
  • Limit alcohol: excess alcohol consumption can lower magnesium levels.
  • Sleep: aim for consistent, adequate sleep to support metabolic and hormonal balance.
  • Physical activity: regular moderate exercise supports overall mineral handling and cardiovascular health. Avoid excessive endurance exercise without proper nutrition and replenishment.
  • Medications: certain diuretics, proton pump inhibitors, and other drugs can reduce magnesium. Review medications with your healthcare provider.

When to Check Your Magnesium

Consider testing if you have symptoms that could indicate low magnesium, such as muscle cramps, weakness, irregular heartbeat, fatigue, or persistent low energy. Routine serum magnesium can be helpful, but note that blood levels reflect only a small portion of total body magnesium. If symptoms persist despite a normal serum magnesium, your clinician may consider additional assessments or empiric dietary and supplement strategies.

Practical Next Steps

  • Review your genotype interpretation above and note which category applies to you.
  • Increase magnesium-rich foods in your daily meals and snacks.
  • If you think you may need a supplement, discuss options and dosing with your healthcare provider.
  • Consider a baseline serum magnesium test if you have symptoms, use medications that affect magnesium, or have conditions that alter mineral balance.
  • Adopt stress reduction, good sleep habits, regular activity, and moderate alcohol intake to support mineral homeostasis.

Important Disclaimer

PlexusDx provides educational information about genetic predispositions only. This content is not medical advice. Genetic results are one piece of information and do not diagnose or predict disease on their own. Always consult your healthcare provider before starting new supplements, changing medications, or making significant lifestyle changes. Your provider can help interpret genetic findings in the context of your medical history, current health, and medications.