HSA | FSA CARDS ARE NOW ACCEPTED

Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

Understanding Your Genetic Result for CDKN2B-AS1 (rs10757274) and Heart Health

Heart disease, also called coronary artery disease, happens when fatty deposits build up inside the arteries that supply your heart. Over time these plaques can narrow arteries, reduce blood flow, and increase the risk of chest pain, fatigue, heart attack, or other cardiovascular events. Both genes and lifestyle factors influence this risk. The CDKN2B-AS1 gene makes a regulatory RNA that affects other genes important for artery health. Variants at rs10757274 in CDKN2B-AS1 are linked to differences in coronary artery disease risk.

How to Read This Result

This report explains what your genotype at rs10757274 means for your genetic predisposition to coronary artery disease and gives practical, approachable recommendations you can discuss with your healthcare provider. Genetics account for roughly 50 to 60 percent of heart disease risk overall, which means lifestyle choices and preventive care matter a great deal for everyone.

Two effect alleles (GG)

Genotype: GG (two copies of the effect allele)

Interpretation: Carrying two G alleles at rs10757274 is associated with an increased risk of coronary artery disease. The CDKN2B-AS1 RNA influences genes that help maintain healthy artery structure and function. Your GG genotype may contribute to a higher lifetime likelihood of developing atherosclerotic plaques in arteries that supply the heart. This genetic influence adds to other inherited and environmental risk factors.

What to consider: Given this elevated genetic risk, prioritizing heart protective habits and regular medical follow up is particularly important. Work with your clinician to assess overall cardiovascular risk, which includes family history, cholesterol levels, blood pressure, blood sugar, weight, and lifestyle factors.

One effect allele (AG)

Genotype: AG (one copy of the effect allele)

Interpretation: Carrying one G allele at rs10757274 is associated with a likely increased risk of coronary artery disease compared with noncarriers. The gene product affects other genes involved in artery health, so this allele may modestly raise your predisposition to plaque buildup in heart arteries.

What to consider: This result suggests you may have an increased genetic tendency toward coronary artery disease but the effect is usually smaller than with two copies. Lifestyle interventions and routine screening are effective ways to reduce overall risk. Discuss personalized screening and prevention strategies with your healthcare provider.

No effect alleles (AA)

Genotype: AA (no effect allele)

Interpretation: Carrying two A alleles indicates a typical genetic risk at this locus. You do not carry the G allele linked to increased coronary artery disease risk at rs10757274. This does not mean zero risk. Heart disease risk remains influenced by many genes and lifestyle factors.

What to consider: Maintain heart healthy habits and follow routine screening as recommended for your age and health status. Healthy choices reduce risk for most people, regardless of genotype.

Practical Lifestyle and Diet Recommendations

  • Mediterranean-style diet: Focus on vegetables, fruits, whole grains, legumes, nuts, seeds, fish, and olive oil. Limit processed foods, sugary drinks, and foods high in saturated fat. Emphasize high fiber choices and lean protein sources.
  • Healthy fats: Choose sources of monounsaturated and polyunsaturated fats such as olive oil, avocados, fatty fish, walnuts, and flaxseed. Reduce intake of trans fats and limit saturated fats found in fatty meats and full-fat dairy.
  • Regular physical activity: Aim for at least 150 minutes per week of moderate aerobic activity or 75 minutes of vigorous activity, plus muscle strengthening two or more days per week. Even brisk daily walks help.
  • Maintain healthy weight: Work toward a body weight that lowers strain on your heart and helps control blood pressure and blood sugar.
  • Quit smoking: Smoking raises cardiovascular risk dramatically. Seek support to stop tobacco use.
  • Limit alcohol: If you drink, do so in moderation. Excess alcohol increases blood pressure and calories and can worsen other risk factors.
  • Manage stress and sleep: Prioritize 7 to 9 hours of sleep per night and practice stress reduction techniques like mindfulness, breathing exercises, or regular physical activity.

Supplement and Nutrient Considerations

  • Omega-3 fatty acids: Fish oil or dietary intake of fatty fish twice weekly may support heart health. Discuss dose and need with your clinician, especially if you take blood thinners.
  • Vitamin D: Low vitamin D is common and may affect cardiovascular health indirectly. Consider testing levels before supplementing and follow your provider's guidance.
  • Fiber and plant sterols: Soluble fiber from oats, legumes, fruits, and vegetables can support healthy cholesterol levels. Plant sterol-enriched foods may also help lower LDL cholesterol when used appropriately.
  • CoQ10: Some people use CoQ10 for general cardiovascular support or if experiencing statin-associated muscle symptoms. Discuss benefits and interactions with your clinician.

Screening, Tests, and When to See Your Healthcare Provider

  • Have regular blood pressure checks and maintain records.
  • Get fasting lipid panel testing to monitor LDL, HDL, and triglycerides on a schedule recommended by your provider.
  • Monitor blood glucose or HbA1c if you have risk factors for diabetes.
  • Discuss whether additional testing such as coronary calcium scoring, carotid ultrasound, or advanced lipid testing is appropriate based on your overall risk profile.
  • If you experience chest pain, shortness of breath, fainting, or sudden weakness, seek immediate medical attention.

Putting Risk in Context

Genetic findings like rs10757274 are one component of risk. Lifestyle choices, clinical measures, and other inherited factors also shape your cardiovascular risk profile. Even if your genotype suggests increased risk, many people reduce their chance of heart disease substantially through diet, exercise, smoking cessation, weight control, and regular medical care. Conversely, a lower-risk genotype does not guarantee protection if other risk factors are present.

Important Disclaimer

PlexusDx does not provide medical advice. This information is educational and not a substitute for professional medical evaluation, diagnosis, or treatment. Always consult your healthcare provider to interpret genetic results in the context of your overall health, to order appropriate tests, and to design a prevention or treatment plan tailored to you.

If this genetic variant is present in your PlexusDx results, the following tests and reports are commonly used to explore it further:

🧬 Genetic Tests:

🧪 Blood Tests:

📄 Genetic Report:

Frequently Asked Questions About HEART DISEASE and CDKN2B-AS1 rs10757274

What does the CDKN2B-AS1 rs10757274 variant mean for my coronary artery disease risk?

The CDKN2B-AS1 gene helps regulate other genes involved in artery health. Variants at rs10757274 are associated with differences in coronary artery disease risk, with your specific genotype (AA, AG, or GG) indicating whether you have typical risk or a likely increased genetic predisposition to plaque buildup in heart arteries.

How should I interpret my rs10757274 genotype (AA, AG, or GG)?

AA (no effect alleles) suggests a typical genetic risk at this locus; you do not carry the G allele linked with increased risk. AG (one effect allele) is associated with a likely modest increase in coronary artery disease risk compared with noncarriers. GG (two effect alleles) is associated with an increased risk, meaning your lifetime likelihood of developing atherosclerotic plaques may be higher, especially alongside other inherited and environmental risk factors.

What lifestyle and screening steps can help reduce heart risk if rs10757274 is linked to higher predisposition?

You can lower overall risk substantially through heart-protective habits: follow a Mediterranean-style diet, choose healthier fats, get regular physical activity, maintain a healthy weight, quit smoking, limit alcohol, and prioritize sleep and stress management. Pair these with routine monitoring such as blood pressure checks, scheduled fasting lipid panels, and blood glucose/HbA1c when indicated, and ask your clinician whether tests like coronary calcium scoring or advanced lipid testing fit your overall risk profile. Seek immediate care for chest pain, shortness of breath, fainting, or sudden weakness.

What tests can help me learn more about HEART DISEASE and CDKN2B-AS1 rs10757274?

The Functional Health Genetic Test delivers over 750 personalized genetic insights across 10 in-depth genetic reports to support whole-body, systems-level health understanding. The Cardiometabolic Genetic Report translates your results into personalized, actionable guidance. Your healthcare provider can also recommend targeted blood tests based on your specific pathway results and health history to complement your genetic insights with current biomarker data.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.