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PlexusDx DNA test kit with smartphone displaying genetic results on a white background
PlexusDx Food Sensitivity & Allergy Genetic Test kit box with 240+ genetic insights for immune response and dietary sensitivities
Targeted DNA recommendations: personalized diet, supplement, and lifestyle insights based on your unique genetic results
Food Sensitivity & Allergy DNA Test
Food Sensitivity & Allergy DNA Test
Your privacy is PlexusDx number one priority: HIPAA-compliant security, advanced encryption, data never sold or shared

Food Sensitivity & Allergy DNA Test

$298.00

240+ Genetic Traits. 2 Comprehensive Reports. 1 Swab.

  • Allergies & Food Sensitivity Report: discover immune responses, environmental and food triggers, and metabolic sensitivities.
  • Diet & Nutrition Report: insights on dietary response, nutrient metabolism, macros, micronutrient and mineral needs.
  • Personalized Diets, Meal Plans, and Supplement Recommendations: custom solutions based on your unique genes and biology, with only the specific nutrients you need.

Comprehensive DNA reports including Food Sensitivities, Intolerances, Allergies, and Environmental Toxins

The Precision Food Sensitivity & Allergy Comprehensive Test offers a personalized approach to managing your environment, diet, and immune health. By analyzing your genetic profile, it reveals how your body detoxifies environmental toxins, identifies food sensitivities, and uncovers predispositions to inflammation and autoimmune risks. Armed with these insights, you'll receive tailored dietary, supplement, and lifestyle recommendations to support detox, bolster immunity, and achieve a balanced, allergy-conscious lifestyle.

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Leverage Genetics to Take Control of Your Allergies, Food Intolerances, and Environmental Sensitivities

With countless wellness options, finding what truly works for your body can be overwhelming. Precision Wellness Tests provide a personalized roadmap by analyzing how your unique genetics impact key health areas. These insights empower you to make informed decisions aligned with your goals—because health isn’t just about the genetic cards you’re dealt; it’s how you play them.

240+ DNA reports including Food Sensitivities, Intolerances, Allergies, and Environmental Toxins

The Food Sensitivity and Allergy Comprehensive Test provides a tailored approach to managing your environment, diet, and immune health based on your unique genetic profile. This test examines how your body handles detoxification from environmental toxins, delivering personalized recommendations to support natural detox processes. It also explores your genetic predispositions to food allergies and sensitivities, helping you make informed dietary adjustments for optimal well-being. With insights into the genetic factors influencing immunity, inflammation, and autoimmune risks, you’ll receive personalized tips to bolster immune resilience and manage inflammation effectively. Additionally, the test identifies specific genetic tendencies toward allergies, offering strategies to minimize reactions and support your immune system. Equip yourself with the insights needed for a balanced, allergy-conscious lifestyle.

Your Food Sensitivity and Allergy Comprehensive Test comes with evidence-based, actionable, and personalized supplement and diet recommendations.

  • WHAT YOU GET: 240+ personalized genetic reports and recommendations related to Food Sensitivities, Intolerances, Allergies, Environmental Toxins and much more
  • WHY PRECISION HEALTH? Precision Health tailors wellness solutions targeting areas like Gluten Sensitivity, Histamine Intolerance, Peanut Allergy, Inflammation, Toxins and more based on your DNA
  • HOW DOES IT WORK? Once you've opened your kit, register by following the instructions inside. Then, collect your sample and mail it back to us using the prepaid return mailer.
  • ACTIONABLE REPORTS: Practical reports for improving your overall wellness, including insights for Egg Allergy, Lactose Intolerance, Oxalate Sensitivity, Supplements, Diet and Lifestyle Recommendations
  • TARGETED INSIGHTS: Tailor your diet, supplements, and lifestyle to your genetic makeup for optimal health and performance.
  • PERSONALIZED RECOMMENDATIONS: Discover personalized diet, supplement, and lifestyle recommendations tailored to your DNA, all evidence-based and backed by 20,000+ clinical trials.
  • ADVANCED DNA TESTING: Get comprehensive reports with personalized diet, supplement, and lifestyle recommendations to achieve your health goals. Analysis of over 200 million genetic variants.
  • YOUR PRIVACY MATTERS: Your privacy is our priority. We use HIPAA compliant security and advanced encryption, ensuring your personal information is always protected.

    • One test for the rest of your life

    Personalized, actionable advice

    Achieve your health goals faster

    Optimize your diet, vitamins, and lifestyle

    Make Targeted Changes Based on Your DNA

    With personalized dietary, supplement, and lifestyle suggestions, you will understand why specific health recommendations are right for your body and tailored to meet your current health needs. Our recommendations are crafted based on your genetic profile because there is no such thing as one-size-fits-all.

    50 %
    of adults in the U.S. have at least one chronic health condition, many of which are impacted by genetic factors.1
    80 %
    of Americans have nutrient deficiencies, which can impact everything from cognitive function to immunity and metabolic health.2
    25 %
    of U.S. adults are affected by mental health conditions, where genetic predispositions play a key role in conditions such as anxiety, depression, and stress management.3

    How It Works

    Discover lifelong insights from one test.

    Order

    Select your test and purchase directly online. 3-5 days later, your kit will arrive at your door.

    Swab

    Follow the instructions included in your kit to ensure you collect an effective sample.

    Results

    Send your completed DNA specimen back and receive your personalized results.

    From Sofa to Science

    Experience the convenience of Precision Wellness right from your home. Just follow the simple steps included with your kit, and soon your detailed report will arrive at your doorstep.

    Your Kit Contains:

    1x INSTRUCTIONS & REGISTRATION CODE
    1x CHEEK SWAB & TRANSPORT TUBE
    1x BIOHAZARD BAG
    1x PREPAID RETURN MAILER

    Food Sensitivity & Allergies Genetic Test

    Frequently asked questions

    What is Nutrigenomics (NGx)?

    Nutrigenomic (NGx) testing investigates the influence of genetic makeup on nutrient needs. The generic advice to “eat right and exercise” means different things depending on your genetics. This test can help you outline what changes you can make to your daily habits that can impact your weight, energy, and overall health.

    Is Nutrigenomics (NGx) right for me?

    Everyone can benefit from knowing how your genetics influence your body’s response to nutrition, providing you with a lifetime of guidance.

    What is the PlexusDx Food Sensitivity & Allergies Genetic Test?

    Key Features of the Test

    • Genetic Insights: Analyzes markers related to food sensitivities (e.g., lactose, gluten), environmental triggers (e.g., mold), and specific allergies like peanuts or milk.
    • Comprehensive Reporting: Covers how your body detoxifies environmental toxins and uncovers risks for inflammation or autoimmune issues.
    • Actionable Guidance: Provides tailored meal plans, supplement suggestions, and lifestyle recommendations based on your unique DNA.
    What is included in the Food Sensitivity & Allergies genetic report?

    Food reactions and allergy-like symptoms can be confusing - especially when they show up as “random” congestion, headaches, skin flare-ups, digestive discomfort, fatigue, or brain fog. The PlexusDx Food Sensitivity & Allergies panel uses your DNA to highlight genetic tendencies related to immune reactivity, histamine handling, and sensitivity patterns to common triggers—so you can make smarter choices, reduce trial-and-error, and build a plan that supports symptom control and quality of life.

    This report is designed to help you understand three key areas: immune responsiveness, environmental allergy risk, and food-trigger patterns.

    1) Immune response: your body’s baseline reactivity

    At the foundation is your genetic tendency for:

    • Immune System: Overall immune responsiveness and how strongly your body may “react” to allergens or irritants. A higher-reactivity pattern can make you more prone to allergy-like symptoms, while a lower-reactivity pattern may reduce sensitivity - though environment still matters a lot.

    This context helps explain why some people can tolerate exposures easily while others feel symptoms quickly.

    2) Histamine: the “allergy signal” that drives many symptoms

    Histamine is a chemical your immune system uses to signal irritation and trigger symptoms like itching, flushing, congestion, headaches, hives, and sometimes digestive upset.

    • Histamine: This trait focuses on genetic tendencies that can affect histamine sensitivity and how your body may break histamine down. If your genetics suggest slower histamine clearance, you may be more likely to feel symptomatic with certain foods, alcohol, or seasonal allergens - especially during high-stress, poor-sleep, or high-exposure periods.

    This section is especially useful for people who experience broad, hard-to-pin-down symptoms that seem to fluctuate.

    3) Common food sensitivities and allergy tendencies

    This panel includes genetic insights for several high-interest food categories that frequently drive avoidance diets and symptom tracking:

    • Gluten: Genetic tendencies related to gluten sensitivity patterns and symptom likelihood.
    • Milk Allergy and Egg Allergy: Indicators tied to immune sensitivity patterns involving common animal-based proteins.
    • Peanut Allergy: Genetic risk tendencies associated with peanut-related immune reactivity.

    These insights are not a diagnosis, but they can help you prioritize which foods are worth testing through elimination-and-reintroduction or discussing with a clinician - rather than cutting everything “just in case.”

    4) Environmental and animal allergens: what you breathe matters too

    Many “food” symptoms are actually driven (or amplified) by environmental allergens that raise baseline immune activation. This report includes genetic tendencies related to:

    • Birch Pollen, Grass Allergy, and Hay Fever: Seasonal allergy susceptibility patterns that can drive congestion, watery eyes, post-nasal drip, cough, fatigue, and sleep disruption.
    • Mold Allergy: Sensitivity patterns related to indoor air quality and damp environments.
    • Cat Allergy and Dog Allergy: Animal dander-related sensitivity tendencies.
    • Cockroach Allergy: A common indoor allergen associated with household exposure patterns, especially in urban environments.
    • Contact Dermatitis: Skin reactivity tendencies that can show up with topical exposures (soaps, fragrances, metals, cleaning products), often presenting as rashes or irritation.

    Understanding your likely environmental triggers can help you reduce the “background inflammation” that makes you feel reactive to everything.

    5) Lifestyle sensitivities that can amplify symptoms

    A few everyday exposures can noticeably worsen symptoms in genetically susceptible people:

    • Alcohol: Alcohol can increase histamine load and disrupt immune balance in some people, which may worsen flushing, headaches, congestion, or skin symptoms.
    • Caffeine: Genetic differences can influence how your body handles caffeine - affecting jitteriness, sleep quality, and stress response, which can indirectly worsen allergy-like symptoms.
    • Mercury Sensitivity: A sensitivity trait that can be relevant for people with higher exposure (dietary or environmental) and who experience symptom flares in response to certain triggers.

    What you get from the Food Sensitivity & Allergies panel

    This report helps you:

    • Identify likely food and environmental triggers worth paying attention to (gluten, milk, egg, peanut, pollens, mold, pets)
    • Understand whether histamine sensitivity may be a major driver of symptoms
    • Reduce trial-and-error with more targeted elimination and exposure strategies
    • Make more informed lifestyle decisions around alcohol, caffeine, and indoor air quality
    • Build a clearer plan to support comfort, energy, skin, and digestion day to day

    It’s a DNA-guided roadmap to help you pinpoint triggers faster and feel more in control—without guessing your way through restrictive diets.

    What is included in the Diet & Nutrition genetic report?

    Most nutrition plans fail for one simple reason: they’re built for the average person. The PlexusDx Diet & Nutrition panel helps you personalize food and supplement choices using your DNA - so you can build an approach that better supports energy, digestion, body composition goals, and long-term cardiometabolic health. This panel focuses on how your genes may influence macronutrient response, heart-healthy lipid handling, nutrient needs, and everyday factors like caffeine and gut comfort.

    1) Find the diet style that fits your body

    Your genetics can influence how you respond to different eating patterns and macro splits. This report includes insights that help you choose the style that’s more likely to work for you—and avoid the ones that tend to backfire.

    • Carbohydrates and high carbohydrate diet: Understand whether your body may handle higher carb intake well, or whether you’re more likely to do better with a moderated approach.
    • High protein diet: Genetics that can influence how well higher protein supports satiety, lean mass, and body composition goals.
    • Fatty acids, lipid metabolism, and low fat diet: Insights related to how you absorb, transport, and utilize fats - useful for choosing the right fat intake and focusing on fat quality.
    • Keto diet: Helps you understand whether a lower-carb, higher-fat approach may be a better fit based on fat handling and lipid-related tendencies.
    • Mediterranean diet: Genetics that often align with cardiometabolic response and “sustainable” eating patterns, supporting heart health and long-term consistency.

    Instead of guessing which plan is “best,” this panel helps you build a plan that’s more compatible with your biology.

    2) Support heart and metabolic health with food choices that matter

    This section highlights genetic tendencies tied to cardiometabolic markers - so you can make more targeted choices around fats, fiber, and overall diet quality.

    • Cholesterol and triglycerides: Understand genetic tendencies that can influence blood lipid response to diet—useful for tailoring fat type, carb quality, and lifestyle habits.
    • Adiponectin: A metabolic signaling marker associated with insulin sensitivity and fat metabolism. Your genetics here can help explain how your body may regulate metabolic flexibility and body fat response to diet.
    • Homocysteine: A marker influenced by both genetics and nutrient status. This report helps identify patterns that may benefit from targeted B-vitamin and methyl-support strategies (especially when paired with smart diet choices).

    3) Personalize digestion and gut comfort

    How you feel after eating is a big part of consistency. The Diet & Nutrition panel includes genetics that can guide food choices for gut comfort:

    • FODMAPs diet: Helps identify whether a low-FODMAP approach may be worth trialing for bloating, gas, abdominal discomfort, or irregularity patterns.
    • Microbiome: Genetic influences that can affect how your gut ecosystem responds to diet, helping you prioritize foods and habits that better support digestive balance.

    This isn’t about restrictions for the sake of restrictions - it’s about finding your best “comfort zone” so you can stick with your plan.

    4) Identify the nutrients your body may need most

    Even the best diet can fall short if key nutrients aren’t being absorbed or utilized efficiently. This report highlights genetic factors related to important vitamins and minerals—so you can prioritize what’s most likely to help.

    Key vitamins

    • Vitamin A, vitamin C, vitamin D, vitamin K
    • Vitamin B12, vitamin B6, riboflavin (B2), biotin (B7)
    • Folate

    Key minerals and electrolytes

    • Calcium, magnesium, zinc, selenium, iron, copper, manganese
    • Sodium, phosphate, molybdenum

    Choline and methyl support

    • Choline: A standout nutrient tied to liver fat handling, brain function, and methyl support. Genetics here can influence dietary needs and how strongly you benefit from choline-rich foods.

    Antioxidant nutrition

    • Antioxidants: Genetic patterns that may influence how much oxidative stress affects you and how strongly you benefit from antioxidant-rich foods and supportive nutrients.
    • Lycopene: A diet-derived antioxidant associated with cellular protection and cardiometabolic support.

    Energy and performance nutrients

    • CoQ10: Supports mitochondrial energy production—often linked to stamina, recovery, and healthy aging.
    • Creatine: Supports power output, strength performance, and brain energy needs.
    • Carnitine: Supports fat transport into mitochondria, influencing energy from fat metabolism—especially relevant for training, recovery, and metabolic efficiency.

    Rather than a generic supplement list, this section helps you focus on high-impact nutrients that align with your genetics and goals.

    5) Everyday insights you’ll use immediately

    Small daily choices can make or break results. This panel includes:

    • Caffeine: Helps explain whether you’re likely to metabolize caffeine quickly or slowly, and how it may impact energy, sleep, and stress response—so you can time intake more strategically.

    What you get from this panel

    The Diet & Nutrition report helps you make smarter decisions by showing you:

    • Which diet styles may fit you best (keto, Mediterranean, higher protein, higher carb, low fat)
    • How your body may respond in key cardiometabolic areas (cholesterol, triglycerides, adiponectin, homocysteine)
    • Where gut comfort strategies may help (FODMAPs, microbiome)
    • Which nutrients to prioritize for best results (vitamins, minerals, antioxidants, and performance nutrients)

    It’s a practical roadmap for eating with more confidence—and far less trial and error.

    Orders

    Find questions related to ordering.

    Does my doctor need to order these tests?

    No. You can order the test directly.

    Can I order these tests for someone else?

    Yes. You can purchase a test for another person. They will need to activate their test kit on our website upon receipt. For minors, parental or guardian consent is required for activation.

    Once someone has successfully responded to PGx registration questions, PlexusDx's Clinician Network will order your test for you.

    How long does it take to receive my results?

    Once we receive your sample at the lab, it takes approximately 10-14 business days to complete the review and analysis for PGx tests and 2-4 weeks for NGx tests.

    Can I use FSA/HSA to cover these tests?

    Yes, the cost of each test is typically reimbursable through both Flexible Spending Accounts (FSA) and Health Savings Accounts (HSA).

    What is Flex and what is their relationship with PlexusDx?

    PlexusDx has partnered with Flex to allow you to use your Health Savings Account (HSA) or Flexible Spending Account (FSA). This means you can now use your HSA or FSA debit card to buy health and wellness tests with pre-tax dollars, resulting in net savings of 30-40%, depending on your tax bracket.

    How do I pay with my HSA or FSA card?

    To use your HSA or FSA debit card, add products to your cart as usual. At checkout, select "Flex | Pay with HSA/FSA" as your payment option, enter your HSA or FSA debit card, and complete your checkout as usual. If you don't see "Flex | Pay with HSA/FSA," you may be in Shop Pay. Select "checkout as guest" to view more payment options.

    What if I don't have my HSA/FSA card available?

    If you don't have your HSA or FSA card handy, still select "Flex | Pay with HSA/FSA" as your payment method. Enter your credit card information and Flex will email you an itemized receipt to submit for reimbursement.

    Why can't I see Flex as a payment method?

    The key here is to make sure you are logged out of Shop Pay. One of the easiest ways to do this is to go through checkout in an incognito window.

    Why is my HSA/FSA card being declined?

    HSA/FSA cards are debit cards, and the most common reason for declines is insufficient funds. Reach out to your HSA/FSA administrator to confirm your balance.

    I submitted my Flex itemized receipt for reimbursement and my FSA requires more information.
    Please forward us the request from your FSA, and we will work with the Flex team to issue you a new receipt.
    Help! I didn't receive an email from Flex with my itemized receipt and/or letter of medical necessity. What should I do?

    Please check your spam folder, as sometimes emails from notifications@withflex.com may be automatically filtered as spam by some email service providers. If you still can't find it, please email support@withflex.com and let them know the email address associated with your order.

    I would like to use multiple HSA/FSA cards to pay for an item. Can I do that?

    No, unfortunately, this isn't a supported feature right now. If there are insufficient funds in a single HSA or FSA account, you can instead enter a credit card on the Flex checkout page. You will receive an itemized receipt and/or Letter of Medical Necessity from Flex, which you can submit for reimbursement.

    Is sales tax covered by HSA/FSA funds, or is it treated separately?

    Sales tax for eligible items is also covered by HSA/FSA funds. If the customer has a split cart, the tax will be divided among the cards based on the items.

    My HSA/FSA Claim was denied. What should I do?

    We strongly recommend checking with your HSA/FSA provider to see if a purchase is eligible prior to completing the purchase. However, if you believe your claim has been wrongly denied, please send over any response from your HSA/FSA provider to us so we can share it with Flex and receive guidance on the next best steps to take. Please note that employer-sponsored FSAs can determine what products are eligible beyond the IRS's guidelines, so it's extremely important to check prior to purchase.

    Can a customer purchase a product now and apply for FSA reimbursement in the next calendar year?

    The ability to apply for FSA reimbursement in a future calendar year depends on the policy of the specific FSA provider. Most FSA administrators require that the purchase be made during the time of coverage. For example, if the FSA coverage is for 2025, all purchases typically need to be made and/or submitted for reimbursement within that coverage period. However, some administrators may have more flexible rules regarding the timing of when the expense occurred. We recommend that customers review their plan policy to confirm the details. Note: Health Savings Accounts (HSAs) are different and generally allow for reimbursement at any time, even in future years.

    Can old (non-Flex) customers use their order confirmation email to apply for HSA/FSA reimbursement?

    Unfortunately, for purchases made without using Flex in the checkout to receive an itemized receipt, it may be difficult to apply for reimbursement. For Health Savings Accounts (HSAs), consumers can use an itemized receipt for reimbursement anytime after they have made the purchase, even if it is many years later. For Flexible Spending Accounts (FSAs), most accounts require that the purchase was made in the calendar year during which the consumer had the FSA, as FSAs typically do not roll over. Some FSAs offer a buffer window, allowing customers additional time to submit receipts for expenses incurred during the previous calendar year.

    Can I speak to a live person?

    Customer Support is available 9am – 5pm EST Monday – Friday.

    877-760-2333

    support@tests.plexusdx.com

    Reporting & Results

    Below are common questions about the test results and reports.

    What is covered by the Precision Wellness Test reports?

    The PlexusDx Precision Wellness Tests cover over 1000 genetic reports related to your overall health. Here is a small sample...

    How you process macronutrients: 

    • Dietary protein
    • Dietary fats
    • Carbohydrates

    Choosing the right types of dietary fat:

    • Saturated fat
    • Omega-3
    • Unsaturated fat

    Getting enough vitamins:

    • Vitamin B6
    • Vitamin E
    • Vitamin D
    • Vitamin B12
    • Folate
    • Vitamin B2
    • Vitamin C
    • Vitamin A
    • Vitamin K

    Getting enough minerals:

    • Zinc
    • Magnesium
    • Iron
    • Potassium
    • Selenium
    • Calcium

    Improving your eating habits:

    • Tendency to overeat
    • Sugar cravings
    • Snacking 
    What steps should I take after getting my test results?

    Receiving your results marks a significant moment in your health journey. They serve as an insightful tool in managing your healthcare effectively. Should you have any inquiries about your results or if you're interested in obtaining clinical advice, please don't hesitate to contact us at results@plexusdx.com.

    Additionally, every client who completes our tests has the opportunity to be connected with either a Clinical Pharmacist or Registered Dietitian through the PlexusDx Network upon request.

    Does this test provide ancestry information?

    This DNA test doesn't offer ancestry details. It focuses solely on how your genes affect your response to specific medications.

    Can this test predict my disease risk?

    This DNA test isn't designed to assess your likelihood of developing diseases, including cancer.

    Privacy

    Below are questions about how we are committed to protecting your privacy and information.

    How does PlexusDx handle my DNA sample?

    Your genetic data is utilized solely for report processing, with no storage or use beyond this requirement. Rest assured, we promptly discard your sample after processing is complete.

    Will you share my data with my insurance or employer?

    No. Your data is for you, and you only.