PlexusDx leads in delivering personalized health reports which provide important insights into genetic traits that influence your overall health.

We investigate the remarkable field of genetics to understand how the FADS1 and FADS2 genes affect fat metabolism and their potential impact on your health.

Genetic Trait:

The FADS1 and FADS2 genes regulate how specific fatty acids undergo metabolism within the body. Variants in genetic material can modify how these genes operate which may result in abnormal levels of fatty acids along with cholesterol and triglycerides. Check this report to learn more.

Trait Overview:

The genes FADS1 and FADS2 produce the protein known as fatty acid desaturase (FADS) or delta-5 desaturase (D5D). The FADS enzyme plays a critical part in fat metabolism through its conversion of polyunsaturated fatty acids (PUFAs). PUFAs fulfill crucial functions in the body including serving as cell structural elements and energy sources while they control cell signaling pathways. Less FADS activity results in diminished quantities of essential PUFAs including EPA and DHA. Fatty acid levels have the potential to disrupt cholesterol and triglyceride concentrations within the body.

Evidence and Explanation:

Research indicates that particular genetic variants in FADS1/2 contribute to fat metabolism problems. A genome-wide study that analyzed 426 Spanish subjects discovered that people carrying the 'T' allele of rs174546 tend to have reduced levels of PUFAs including omega-6 fatty acid AA and omega-3 fatty acids EPA and DHA. The genetic variant affects how ALA from plants transforms into EPA and DHA. A study conducted on 224 individuals from an isolated island population in the U.S. showed that the ‘T’ allele correlates with diminished levels of omega-6 fatty acids. The allele shows a correlation with increased triglyceride levels while showing a decrease in LDL and total cholesterol. The findings come from studies conducted in European, Canadian, and Mexican populations. Other SNPs including rs174547, rs174548, and rs174550 have shown comparable findings. The minor allele in each case led to reduced D5D activity together with declining amounts of omega-3 and omega-6 fatty acids. When these alleles are inherited they tend to come together which means that you will most likely possess all the minor variants at once or none at all. Researchers evaluated the SNP rs174547 in populations exceeding 21,000 Japanese people and 1,200 Mongolian people. The ‘C’ allele demonstrated a connection with increased triglycerides levels and decreased HDL cholesterol levels among Japanese participants. Among Mongolian individuals the ‘C’ allele affected LDL cholesterol levels without changing HDL or triglyceride levels. Research has shown that the presence of the ‘C’ allele in rs174547 leads to reduced LDL levels in individuals who consume limited omega-3 fatty acids. Research from Chinese populations indicates that individuals with the ‘C’ allele of rs174550 tend to have reduced HDL levels along with increased triglyceride levels.

Practical Advice:

Knowledge about your genetic predispositions allows you to make educated health decisions. Below you will find actionable tips based on PlexusDx insights starting with point number one.

  1. Consult a healthcare provider: It's important to share your genetic test results with a skilled healthcare expert who can offer you individualized advice based on your genetic makeup.
  2. Dietary adjustments: Incorporate omega-3 rich foods into your diet to support your body's fat metabolism and enhance your general health.
  3. Regular monitoring: Maintain regular health screenings to monitor your cholesterol and triglyceride levels so you can identify any imbalances promptly.
  4. Lifestyle modifications: Achieve complete well-being through consistent physical exercise and stress management which together maintain a healthy lifestyle.

Conclusion:

The FADS1 and FADS2 genes serve as essential components in fat metabolism and genetic variations within these genes influence how efficiently your body processes fatty acids. Precision Health & Wellness tests from PlexusDx which you can purchase through their website PlexusDx.com, Amazon and Walmart enable you to understand your genetic predispositions and take proactive actions to improve your health. Understanding your health information gives you control over your well-being. Begin your journey to personalized health awareness today to discover how you can live a healthier and more knowledgeable life.