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Functional Health DNA Test
Functional Health DNA Test
Functional Health DNA Test
Functional Health DNA Test
Functional Health DNA Test

Functional Health DNA Test

$398.00

750+ Genetic Traits. 10 Comprehensive Reports. 1 Swab.

  • Methylation & Detox Reports: understand and support your energy, mood, focus, cellular repair and how your body handles toxins.
  • Nutrition & Weight Loss Reports: insights on dietary response, nutrient metabolism, macros, hunger, cravings, fat distribution, weight regain.
  • Allergies & Food Sensitivity Report: discover immune responses, environmental and food triggers, and metabolic sensitivities.
  • Fitness & Injury Report: understand your genetics related to endurance, strength response, recovery, lean mass, metabolic rate, motivation
  • Hormone & Reproductive Reports: insights on fertility/pregnancy plus estrogen, progesterone & testosterone pathways, PMS/PMDD, hot flashes & metabolism.
  • Longevity & Cardiometabolic Reports: unlock the secrets to healthy aging with insights related to lifespan, hearing, vision, skin health, inflammation, fatigue, pain, heart health, blood pressure, diabetes, and more.
  • Personalized Diets, Meal Plans, and Supplement Recommendations: custom solutions based on your unique genes and biology, with only the specific nutrients you need.
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Use the Power of Genetics to Take Control of Your Functional Health

With countless wellness options, finding what truly works for your body can be overwhelming. Precision Wellness Tests provide a personalized roadmap by analyzing how your unique genetics impact key health areas. These insights empower you to make informed decisions aligned with your goals—because health isn’t just about the genetic cards you’re dealt; it’s how you play them.

750+ DNA reports including Cardiovascular, Nutrition, Gut Health, Hormones, Diet and Microbiome

The Precision Functional Health Genetic Test offers a comprehensive insight into the key genetic factors that impact your body's core functions, helping you take a proactive approach to maintaining overall health and resilience. This test examines genetic predispositions for kidney health, providing personalized recommendations to support and protect kidney function. It also provides valuable insights into metabolic health, equipping you with tailored strategies for balanced weight and blood sugar control. By analyzing hormone health, the test offers targeted advice for achieving optimal hormonal balance. Cardiovascular health is another critical focus, with genetic insights into heart and blood vessel health, offering specific strategies to support cardiovascular wellness. Additionally, the test reveals genetic risks related to liver and gallbladder function, giving you actionable tips to maintain these essential organs. With insights into gut health and digestion, this test also provides recommendations for a balanced microbiome and digestive well-being. Empower yourself with this all-encompassing tool to support long-term, functional health.

Your Precision Functional Health Genetic Test comes with evidence-based, actionable, and personalized supplement, diet and lifestyle recommendations.

  • WHAT YOU GET: 750+ personalized genetic reports and recommendations related to Cardiovascular, Nutrition, Gut Health, Hormones, Diet and Microbiome and much more
  • WHY PRECISION HEALTH? Precision Health tailors wellness solutions targeting areas like Inflammation, Microbiome, Cholesterol, Underactive Thyroid, Fatty Liver and more based on your unique DNA
  • HOW DOES IT WORK? Once you've opened your kit, register by following the instructions inside. Then, collect your sample and mail it back to us using the prepaid return mailer.
  • ACTIONABLE REPORTS: Practical reports for improving your overall wellness, including insights for Digestion, Hormones, Metabolism, Detox, Supplements, Diet and Lifestyle Recommendations
  • TARGETED INSIGHTS: Tailor your diet, supplements, and lifestyle to your genetic makeup for optimal health and performance.
  • PERSONALIZED RECOMMENDATIONS: Discover personalized diet, supplement, and lifestyle recommendations tailored to your DNA, all evidence-based and backed by 20,000+ clinical trials.
  • ADVANCED DNA TESTING: Get comprehensive reports with personalized diet, supplement, and lifestyle recommendations to achieve your health goals. Analysis of over 200 million genetic variants.
  • YOUR PRIVACY MATTERS: Your privacy is our priority. We use HIPAA compliant security and advanced encryption, ensuring your personal information is always protected.

    • One test for the rest of your life

    Personalized, actionable advice

    Achieve your health goals faster

    Optimize your diet, vitamins, and lifestyle

    Make Targeted Changes Based on Your DNA

    With personalized dietary, supplement, and lifestyle suggestions, you will understand why specific health recommendations are right for your body and tailored to meet your current health needs. Our recommendations are crafted based on your genetic profile because there is no such thing as one-size-fits-all.

    50 %
    of adults in the U.S. have at least one chronic health condition, many of which are impacted by genetic factors.1
    80 %
    of Americans have nutrient deficiencies, which can impact everything from cognitive function to immunity and metabolic health.2
    25 %
    of U.S. adults are affected by mental health conditions, where genetic predispositions play a key role in conditions such as anxiety, depression, and stress management.3

    How It Works

    Discover lifelong insights from one test.

    Order

    Select your test and purchase directly online. 3-5 days later, your kit will arrive at your door.

    Swab

    Follow the instructions included in your kit to ensure you collect an effective sample.

    Results

    Send your completed DNA specimen back and receive your personalized results.

    From Sofa to Science

    Experience the convenience of Precision Wellness right from your home. Just follow the simple steps included with your kit, and soon your detailed report will arrive at your doorstep.

    Your Kit Contains:

    1x INSTRUCTIONS & REGISTRATION CODE
    1x CHEEK SWAB & TRANSPORT TUBE
    1x BIOHAZARD BAG
    1x PREPAID RETURN MAILER

    Comprehensive Functional Health Genetic Test

    The following questions are specific to the PlexusDx Functional Health Genetic Test

    What is the PlexusDx Functional Health Genetic Test and what reports are included?

    The PlexusDx Functional Health Genetic Test is an at-home DNA test that analyzes your genetics to deliver personalized, actionable health insights across key biological systems, translating more than 750 genetic insights into clear guidance you can use to make smarter nutrition, lifestyle, and wellness decisions. It includes 10 genetic reports: Methylation Pathway, Detoxification, Diet and Nutrition, Weight and Body Fat, Fitness and Injury, Allergies and Food Sensitivities, Hormone and Fertility Health, Longevity and Lifespan, Healthy Aging, and Cardiometabolic Health.

    What is included in the Methylation Pathway genetic report?

    Methylation is one of the body’s most important behind-the-scenes systems, supporting energy production, balanced brain chemistry, detox support, cellular repair, and healthy aging. The PlexusDx Methylation Pathways panel reviews key genetic pathways that influence how efficiently you create, recycle, and use methyl groups, and it highlights where targeted nutrition and lifestyle support may help most.

    Core methylation cycles

    • Folate cycle: Converts folate into active forms used for DNA building, repair, and methylation. Genetic differences here can affect methylation efficiency and which folate forms may be most helpful.
    • Methionine cycle: Produces and recycles SAMe, the body’s primary methyl donor. This cycle influences methylation capacity, neurotransmitter balance, and homocysteine handling.

    These cycles help power essential “maintenance” tasks, especially during stress, poor sleep, intense training, or nutrient gaps.

    Pathways tied to detox and recovery

    • Transsulfuration: Links methylation to sulfur metabolism and glutathione precursor production, influencing antioxidant capacity, inflammation balance, and recovery from oxidative stress.
    • Glutathione redox cycle: Reflects how well glutathione may be recycled for cellular protection and resilience.
    • Formate metabolism: Supports one-carbon metabolism connected to methylation and DNA synthesis.

    Brain and mood-related pathways

    • BH4 cycle: Supports neurotransmitter production and nitric oxide signaling, with potential links to mood, focus, and stress response.
    • Neurotransmitter methylation: Affects how neurotransmitters are methylated and broken down, shaping mental clarity and stress response.
    • Histamine degradation: May relate to histamine sensitivity patterns such as headaches, flushing, congestion, skin reactivity, sleep disruption, or a “wired but tired” feeling.

    Nitrogen balance and cellular growth

    • Urea cycle: Helps clear ammonia and manage nitrogen balance, supporting protein metabolism, exercise recovery, and cognitive clarity.
    • Polyamine cycle: Supports cell growth, repair, and healthy aging, with genetics that may influence cellular turnover and resilience.

    Key nutrient cofactors

    The panel includes genetic insights tied to nutrients that support these pathways, including choline and betaine, folate and B12, B6 and riboflavin (B2), vitamin C, selenium, zinc, magnesium, iron, methionine, and NAC.

    What this panel helps you do

    You will see where you may be naturally efficient, where extra support may be useful, and which diet and supplement strategies best fit your biology, with practical guidance for energy, mood, detox support, and long-term wellness.

    What is included in the Detoxification genetic report?

    Detoxification is your body’s built-in cleanup system, helping you process everyday exposures from food, air, water, personal care products, and lifestyle factors. The PlexusDx Detoxification panel reviews genetic pathways that shape how efficiently you activate, neutralize, and eliminate common compounds, and how resilient you may be to oxidative stress, the wear-and-tear effect of inflammation, stress, and environmental load. The goal is to help you make smarter choices and personalize support based on your biology.

    The detox two-step: Phase 1 and Phase 2

    Detox is a coordinated process:

    Phase 1 detox: Enzymes convert compounds into intermediate forms. If Phase 1 runs quickly, reactive byproducts can build up if Phase 2 and antioxidant defenses do not keep pace.

    Phase 2 detox: Neutralizes and prepares compounds for removal by making them more water-soluble so they can be eliminated through bile, urine, and sweat.

    Overall balance: Genetics can tilt you toward being more activation-heavy or clearance-heavy, which may influence sensitivity to exposures, including headaches, fatigue, brain fog, nausea, skin issues, or sensitivity to smells and chemicals.

    This panel helps clarify whether you may benefit more from supporting clearance, reducing exposure, or strengthening antioxidant capacity.

    Oxidative stress and antioxidant defenses

    Because detox processes can generate reactive compounds, the report also evaluates genetic tendencies related to:

    • Oxidative stress sensitivity: How strongly you may be affected by inflammation, intense exercise, poor sleep, or higher environmental load.
    • Antioxidant protection: How well your body may buffer oxidative damage, which can matter for energy, recovery, skin health, and long-term wellness.

    Common exposure pathways covered

    The panel includes genetic insights related to processing and sensitivity patterns for:

    • Alcohol detoxification: Efficiency of processing alcohol and byproducts, which can relate to sensitivity and next-day effects.
    • Nicotine detoxification: Differences in how nicotine exposure may be processed, including secondhand exposure.
    • Mold and fungal toxins: Patterns tied to indoor air quality and mycotoxin-like exposures.
    • Heavy metals: Lead, arsenic, and mercury-related pathways that may influence sensitivity and the value of exposure reduction.

    Chemical and pollutant sensitivities

    Genetics related to processing and sensitivity patterns for common environmental exposures, including:

    • BPA detoxification and phthalate sensitivity
    • PBDE sensitivity, often linked to flame retardants and household dust
    • Benzene sensitivity and PAH sensitivity, associated with exhaust, smoke, and some high-heat cooking exposures
    • Glyphosate sensitivity patterns
    • Organophosphate pesticide and pyrethroid detoxification pathways

    These insights do not confirm exposure. They highlight where reducing exposure may be especially worthwhile.

    What you get from this panel

    The Detoxification report translates complex genetics into practical guidance to help you:

    • Understand your Phase 1 and Phase 2 balance
    • Identify potential sensitivities related to chemicals, mold, heavy metals, and pesticides
    • Support antioxidant defenses and oxidative stress resilience
    • Make more informed choices around environment, diet, and lifestyle to improve day-to-day well-being
    What is included in the Diet & Nutrition genetic report?

    Most nutrition advice is one-size-fits-all. Your body is not. The PlexusDx Diet and Nutrition panel turns your DNA into practical guidance on how you may respond to different foods, macronutrients, and key nutrients, so you can make smarter choices for energy, body composition, heart health, digestion, and long-term wellness. It helps you focus on what is most likely to work for you.

    Macronutrients and diet-style fit

    Your genes can influence how you handle carbohydrates, fats, and protein, and which eating patterns may suit you best:

    • Carbohydrates and higher-carb patterns: How you may process carbs and whether a higher-carb approach may be a good fit.
    • Fats and lipid metabolism: How you may handle fats, which can help guide fat intake and food quality.
    • Higher-protein patterns: Whether higher protein may better support satiety, lean mass, and metabolic goals.
    • Keto-style approaches: Genetic tendencies tied to fat-based fueling and lipid handling that may make keto easier or harder.
    • Mediterranean-style eating: Patterns often linked to cardiometabolic response, useful for sustainable heart-healthy habits.

    Heart and metabolic health signals

    This panel includes genetic insights related to cardiometabolic markers and body composition tendencies:

    • Cholesterol and triglycerides: Tendencies in blood fats and how strongly diet may affect them.
    • Adiponectin: A hormone-like signal tied to insulin sensitivity and metabolic flexibility.
    • Homocysteine: A marker influenced by genetics and nutrient status, often linked to cardiovascular and metabolic health.

    Digestion and food tolerance

    Genetics can offer a smarter starting point for gut comfort:

    • FODMAP-related patterns: Whether a low-FODMAP trial may be worth considering for bloating, gas, or irregularity.
    • Microbiome-related tendencies: Genetic influences on gut environment and diet response.

    Micronutrients and performance nutrients

    Your nutrient needs and utilization can vary. This panel helps you prioritize:

    • Vitamins: A, C, D, K, folate, B12, B6, riboflavin, biotin
    • Minerals: magnesium, zinc, selenium, iron, copper, manganese, calcium, sodium, phosphate, molybdenum
    • Choline: Important for brain function, liver fat handling, and methyl support
    • Energy and fitness nutrients: CoQ10, creatine, carnitine, lycopene

    Lifestyle nutrition insights

    • Caffeine: Likely sensitivity and metabolism speed, useful for sleep and energy balance.
    • Antioxidant response: Tendencies that may influence how much you benefit from antioxidant-rich foods.

    What you get from this panel

    The Diet and Nutrition report helps you choose a diet style that better fits your biology, prioritize the nutrients most likely to matter for you, support heart and metabolic health with targeted decisions, and reduce food trial and error so you can eat and supplement with more confidence.

    What is included in the Weight & Body Fat genetic report?

    Weight loss is not only about calories. Appetite signals, cravings, blood sugar response, and fat storage patterns can all be influenced by genetics. The PlexusDx Weight and Body Fat panel helps you understand the drivers that may make weight management easier or harder for you, so you can build a plan that works with your biology.

    Appetite, cravings, and eating behavior

    This section looks at real-world consistency factors, including genetic tendencies related to:

    • Hunger and fullness signals
    • Snacking and between-meal cravings
    • Overeating and response to highly palatable foods
    • Emotional eating under stress, low mood, or fatigue
    • Sweet cravings and reward response to sugary foods

    These insights can guide practical strategies such as higher-protein meals, better meal timing, fiber targets, and trigger-food planning.

    Blood sugar and weight-loss resistance

    Blood sugar stability can shape hunger, energy, and progress. This section includes genetics related to:

    • Glucose control and blood sugar swings that may drive cravings or crashes
    • Weight-loss response, including where more precision may help with macros, timing, activity, or recovery
    • Weight regain tendencies after dieting

    Fat storage and body composition

    Not all weight is the same. This section covers genetic tendencies related to:

    • Fat distribution patterns
    • Sensitivity to dietary fat intake
    • Muscle mass maintenance and development, which can affect metabolism and glucose control
    • Baseline body weight tendency, including BMI and obesity-related risk patterns

    Nutrition levers tied to body fat outcomes

    This panel also highlights genetics connected to:

    • Fiber response for fullness, blood sugar balance, and weight control
    • Response to monounsaturated fats and saturated fats for satiety and metabolic support

    What you get from this panel

    You can use this report to:

    • Identify likely blockers such as hunger, snacking, sugar cravings, overeating, and emotional eating
    • Choose tactics that improve adherence and reduce cravings
    • Support steadier energy through better blood sugar control
    • Train and eat more effectively based on fat distribution and muscle tendencies
    • Lower the risk of weight regain with a plan you can maintain
    What is included in the Fitness & Injury genetic report?

    The best workout plan is one your body can recover from, adapt to, and stick with. The PlexusDx Fitness and Injury panel uses your DNA to help you train smarter for better performance, improved body composition, stronger recovery, and fewer setbacks.

    Performance potential

    Your genetics can offer clues about the training mix you may respond to best, including:

    • Endurance capacity, including aerobic efficiency and oxygen delivery
    • Endurance versus power tendencies, which can guide steady-state training and high-intensity work
    • Strength and resistance training response, including muscle and grip strength markers
    • Explosive power traits that may support sprinting, jumping, HIIT, and strength-focused goals
    • Lean body mass potential, which can influence how quickly you see visible changes

    Recovery and resilience

    Progress depends on how well you recover. This section covers genetic tendencies related to:

    • Recovery speed and optimal training frequency
    • Muscle soreness and damage response, which can inform volume and intensity
    • Pain sensitivity and how training may feel day to day
    • Stress response, since stress can impair recovery and raise injury risk
    • Motivation and activity drive, which helps shape a plan you can maintain

    Metabolism and body composition

    Training affects more than fitness. This panel includes genetics linked to:

    • Resting metabolic rate and baseline calorie burn
    • How strongly exercise may support fat loss for you
    • Glucose response and insulin sensitivity changes with training
    • Lipid response, including triglycerides and HDL cholesterol
    • Blood pressure tendencies that can inform training and recovery priorities

    Injury risk and durability

    This section highlights genetics related to staying durable, including:

    • Tendon strength and tolerance to repetitive load
    • Collagen and soft-tissue injury susceptibility to support smarter progression and warmups
    • Concussion-related considerations for contact or higher-risk activities

    What you get from this panel

    You can use this report to:

    • Choose a training style that fits you, whether endurance, strength, power, or a blend
    • Plan recovery so you train consistently without burnout
    • Support fat loss and metabolic health with the right cardio and strength balance
    • Reduce injury risk with smarter progression and connective-tissue support
    • Build a routine you are more likely to sustain based on motivation and stress patterns
    What is included in the Longevity & Lifespan genetic report?

    Healthy aging is not one single pathway. It is a collection of systems that influence how well your body maintains cells, protects tissues from damage, and stays resilient over time. The PlexusDx Longevity and Lifespan panel turns your DNA into practical guidance across the core biological drivers linked to long-term health, cardiovascular resilience, and cellular aging. This report helps you focus on the habits and nutrients that are most likely to support your body as you age, based on how you are built.

    1) Cellular aging and repair capacity

    A major pillar of longevity is how well your cells protect and renew themselves over time.

    • Telomeres: Telomeres are protective caps on the ends of chromosomes that naturally shorten with aging. Genetic differences can influence how quickly telomeres may shorten and how resilient your cells may be under stress. This section helps you understand your baseline cellular aging tendency and where lifestyle support may be most beneficial.
    • Heat shock proteins: These proteins help cells respond to stress by stabilizing and repairing damaged proteins. They play an important role in recovery, resilience, and maintaining healthy cellular function as you age. Your genetics may influence how strongly your body activates this protective system.

    2) Metabolic energy and cellular renewal pathways

    Longevity depends on efficient energy production and strong cellular maintenance systems.

    • NAD+: NAD is a central molecule used in energy production, DNA repair, and cellular signaling. It also supports pathways often linked to healthy aging. This part of the report highlights genetic patterns that may influence NAD-related efficiency and where supportive strategies may be most relevant.

    3) Hormone-like aging regulators and resilience

    Some genes act like master switches for aging-related pathways.

    • Klotho: Klotho is often described as a longevity-associated protein that may support brain health, vascular function, and metabolic resilience. Genetic differences in Klotho-related pathways can influence how strongly you may benefit from lifestyle habits that support cognitive and cardiovascular aging.

    4) Cardiovascular and lipid factors that shape lifespan

    For many people, long-term health is closely tied to heart and vascular function.

    • Cholesterol: Your genetics can influence how your body manages cholesterol and how strongly diet and lifestyle may impact it. This section helps prioritize heart-smart nutrition and habits based on your inherited tendencies.
    • Heart health: This includes genetic drivers tied to vascular function and long-term cardiovascular resilience. It helps you understand whether focusing on blood pressure support, inflammation balance, activity, and cardiometabolic habits may be especially high return for you.

    5) Overall longevity tendency

    This section brings the systems together into a clearer picture of your long-term resilience.

    • Longevity: Your longevity genetics reflect a combined influence of cellular maintenance, stress resilience, metabolism, and cardiovascular factors. This is not destiny, but it can highlight the areas where you may have more natural resilience and where you may benefit most from consistent support.

    What you get from this panel

    The Longevity and Lifespan report helps you:

    • Understand your cellular aging and stress resilience systems, including telomeres and heat shock proteins
    • Support long-term cellular energy and repair capacity through NAD-linked pathways
    • Learn how a key longevity regulator like Klotho may influence resilience as you age
    • Personalize heart-smart strategies using cholesterol and heart health genetics
    • Focus on the highest impact habits for your biology, based on your overall longevity profile

    This panel is designed to turn complex aging biology into clear, practical priorities you can act on today.

    What is included in the Healthy Aging genetic report?

    Healthy aging is about staying strong, comfortable, and confident in your body as the years add up. The PlexusDx Healthy Aging panel translates your DNA into practical guidance across visible aging, joint and mobility health, inflammation and energy, and longer-term risks that can impact quality of life. This report helps you focus on the areas where you may be more sensitive and where consistent habits can make the biggest difference.

    1) Skin and appearance aging

    This section looks at genetic tendencies tied to how your skin responds to time, sunlight, and collagen support.

    • Skin aging: A big-picture view of your inherited tendency toward visible aging changes, including firmness, texture, and resilience.
    • Wrinkles: Genetics that can influence collagen support, skin elasticity, and how quickly fine lines may develop over time.
    • Sun spots: Helps explain how strongly sun exposure may affect pigmentation changes and uneven tone.
    • Stretch marks: Links to connective tissue and skin elasticity that can affect how skin responds to growth, weight changes, or pregnancy.
    • Droopy eyelids: A trait tied to structural and connective tissue factors that can influence skin support around the eyes.
    • Gray hair: Genetic patterns related to hair pigment maintenance that can influence when graying may occur.
    • Skin cancer: Highlights genetic susceptibility patterns related to skin cancer risk, helping you prioritize sun protection behaviors and skin screening routines.

    This section is designed to help you personalize prevention, not to predict a specific outcome.

    2) Mobility, joints, and everyday comfort

    Aging well depends heavily on maintaining joint function, connective tissue strength, and pain-free movement.

    • Back pain: Looks at inherited tendency toward back discomfort and structural sensitivity, supporting smarter choices around movement, posture, and strength training habits.
    • Arthritis: Genetics linked to joint wear-and-tear and inflammation-related joint changes that can affect stiffness and comfort over time.
    • Tendonitis: Genetic patterns that may influence tendon resilience and irritation risk, useful for training decisions and recovery strategies.
    • Osteoporosis: Evaluates genetic tendencies related to bone density maintenance and fracture risk, helping guide strength training, protein intake, and bone-supportive nutrients.

    This section can help you train and move in a way that supports long-term mobility.

    3) Inflammation, fatigue, and recovery

    Many aging-related symptoms are strongly influenced by how your body handles inflammation and stress.

    • Inflammation: Genetic tendencies related to inflammatory signaling, which can influence joint comfort, skin health, recovery, and overall resilience.
    • Fatigue: Genetics that may contribute to differences in energy regulation and how strongly stressors like poor sleep, overtraining, or nutrient gaps impact your day-to-day stamina.

    This part of the report helps you focus on high return levers like sleep quality, exercise recovery, and anti-inflammatory nutrition patterns.

    4) Oral and sensory health

    Quality of life includes strong oral health and maintaining the senses that keep you connected.

    • Gum disease: Genetic susceptibility patterns related to periodontal inflammation and tissue response, supporting smarter prevention habits and dental maintenance.
    • Hearing loss: Genetics linked to age-related hearing decline risk, helping you prioritize protective habits and earlier screening if needed.

    5) Longer-term aging risks that can affect wellbeing

    This panel also includes traits tied to health conditions that commonly increase with age and can impact comfort and independence.

    • Gallstones: Genetic tendencies related to bile and cholesterol handling that may influence risk patterns over time.
    • Blindness: Broad genetic susceptibility signals related to vision health risks that can guide prevention habits and screening awareness.

    What you get from this panel

    The Healthy Aging report helps you:

    • Personalize skin and appearance aging support, including wrinkles, sun spots, stretch marks, droopy eyelids, gray hair, skin aging, and skin cancer
    • Support long-term mobility with insights on back pain, arthritis, tendonitis, and osteoporosis
    • Understand your baseline patterns for inflammation and fatigue to improve recovery and daily energy
    • Strengthen prevention strategies for gum disease and hearing loss
    • Stay proactive about aging-related risks like gallstones and vision health

    This panel is designed to help you age with more strength, comfort, and confidence by focusing on the areas where your DNA suggests you may benefit most from targeted support.

    What is included in the Cardiometabolic genetic report?

    Cardiometabolic health is the foundation for long-term energy, performance, and healthy aging. It reflects how well your body manages blood flow, blood pressure, blood sugar, and blood fats, along with key factors involved in vascular function and clotting. The PlexusDx Cardiometabolic panel translates your DNA into clear, practical guidance so you can personalize nutrition, exercise, and lifestyle choices that support heart and metabolic resilience over time.

    1) Heart and vascular risk signals

    This section focuses on genetic tendencies that can influence long-term cardiovascular health and circulation.

    • Heart disease: A broad view of inherited risk patterns tied to cardiovascular outcomes. This helps you prioritize the habits that matter most for your biology, including activity, sleep, stress support, and diet quality.
    • Nitric oxide: Nitric oxide supports blood vessel relaxation and healthy blood flow. Genetics here can influence vascular tone and exercise response, and can help guide strategies that support circulation and endothelial health.

    2) Blood pressure regulation

    Blood pressure is one of the most important measurable drivers of long-term cardiovascular outcomes.

    • Blood pressure: This section evaluates genetic tendencies related to blood pressure regulation, which can guide personalized strategies around sodium balance, weight management, activity, sleep quality, and stress response.

    3) Blood clotting and circulation balance

    Clotting is a normal and necessary process, but differences in clotting factors can influence how your body balances clot formation and healthy circulation.

    • Blood clots: Genetic susceptibility patterns tied to clotting tendency, which may help you understand personal risk signals and inform discussions with a clinician when relevant.
    • Fibrinogen: Fibrinogen is a key clotting protein that also relates to inflammation and cardiovascular risk. Genetics affecting fibrinogen can influence baseline clotting and inflammatory balance.

    This section is designed to support awareness and prevention habits, not to diagnose any condition.

    4) Blood fats and lipid handling

    Your lipid profile is strongly influenced by both genes and lifestyle. This panel helps you focus your efforts where they are most likely to pay off.

    • Triglycerides: Genetic tendencies related to triglyceride levels and response to diet and exercise. This can guide choices around carbohydrate quality, alcohol intake, omega-3 rich foods, fiber, and activity patterns.

    5) Blood sugar and metabolic resilience

    This section focuses on genetic drivers tied to how your body handles glucose and insulin over time.

    • Diabetes: Genetic tendencies related to type 2 diabetes risk, helping prioritize strategies that support glucose control and insulin sensitivity.
    • Metabolic syndrome: A broader risk pattern related to waist circumference, blood pressure, triglycerides, blood sugar, and HDL balance. Genetics can influence how easily you drift toward this cluster and which habits help most.

    What you get from this panel

    The Cardiometabolic report helps you:

    • Understand your inherited patterns for heart disease risk and vascular function, including nitric oxide support
    • Personalize strategies for blood pressure management
    • Gain clarity on clotting-related factors like blood clots and fibrinogen
    • Optimize diet and exercise choices to improve triglycerides and overall lipid response
    • Support metabolic health with insights on diabetes and metabolic syndrome risk patterns

    This panel turns complex cardiometabolic genetics into practical priorities so you can take action early and stay consistent with what works best for your body.

    What is included in the Allergies & Food Sensitivities genetic report?

    Food reactions and allergy-like symptoms can feel random, showing up as congestion, headaches, skin flares, digestive discomfort, fatigue, or brain fog. The PlexusDx Food Sensitivity and Allergies panel uses your DNA to highlight genetic tendencies related to immune reactivity, histamine handling, and sensitivity patterns to common triggers, so you can reduce trial and error and make more targeted choices.

    Immune responsiveness

    This section looks at your baseline immune reactivity and how strongly your body may respond to allergens and irritants, which can influence how quickly symptoms show up.

    Histamine handling

    Histamine is a key driver of symptoms such as itching, flushing, congestion, headaches, hives, and sometimes digestive upset. The panel evaluates genetic tendencies that may affect histamine sensitivity and breakdown, which can help explain why symptoms fluctuate with certain foods, alcohol, stress, poor sleep, or seasonal exposure.

    Food-trigger patterns

    The report includes genetic insights related to common food sensitivity and allergy tendencies, including:

    • Gluten-related sensitivity patterns
    • Milk and egg-related immune sensitivity tendencies
    • Peanut-related immune reactivity tendencies

    These insights are not a diagnosis, but they can help you prioritize what is worth testing through structured elimination and reintroduction or discussing with a clinician.

    Environmental and contact triggers

    Many symptoms are driven or amplified by environmental allergens. This panel includes tendencies related to:

    • Seasonal allergies such as birch pollen, grass allergy, and hay fever
    • Mold sensitivity patterns linked to indoor air quality
    • Cat and dog dander sensitivity tendencies
    • Cockroach allergen sensitivity patterns in indoor environments
    • Contact dermatitis tendencies that may show up with topical exposures such as fragrances, soaps, metals, and cleaning products

    Lifestyle sensitivities that can amplify symptoms

    This section covers genetic tendencies related to exposures that may worsen symptoms for some people, including alcohol, caffeine response, and mercury sensitivity patterns.

    What you get from this panel

    You can use this report to:

    • Identify likely food and environmental triggers to pay attention to
    • Understand whether histamine sensitivity may be a major driver
    • Reduce guesswork with more targeted elimination and exposure strategies
    • Make smarter choices around alcohol, caffeine, and indoor air quality
    • Build a clearer plan to support comfort, energy, skin, and digestion day to day
    What is included in the Hormone & Fertility Health genetic report?

    Hormones influence how you feel day to day, including energy, mood, sleep, metabolism, skin, and reproductive health. The PlexusDx Hormone and Fertility Health panel translates your DNA into practical guidance across hormone balance, cycle symptoms, thyroid function, and fertility-related traits. It is designed to help you understand your baseline tendencies and personalize nutrition, lifestyle, and conversations with your clinician when needed.

    1) Core hormone pathways that shape daily wellbeing

    This section focuses on genetic patterns tied to how your body produces, uses, and clears key hormones.

    • Estrogen: Genetics related to estrogen balance can influence cycle regularity, mood patterns, skin changes, and how strongly you experience hormonal shifts. It can also affect how your body processes estrogen over time.
    • Progesterone: Progesterone supports cycle balance, sleep quality, calm mood signaling, and early pregnancy support. Genetic tendencies here may influence luteal phase symptoms and cycle comfort.
    • Testosterone: Testosterone influences muscle mass, libido, motivation, and energy in all sexes. Genetics can affect androgen sensitivity and how strongly lifestyle factors influence levels and effects.

    These traits help explain why some people feel more sensitive to hormonal changes, while others feel more stable.

    2) Thyroid and metabolic regulation

    Thyroid hormones are central to metabolism, temperature regulation, energy, and mental clarity.

    • Thyroid: This section evaluates genetic tendencies tied to thyroid function and hormone signaling, which can inform strategies around nutrition, stress management, sleep, and symptom tracking.

    This is especially helpful for people who feel chronically low energy, struggle with weight changes, or notice cold sensitivity and brain fog patterns.

    3) Cycle symptoms and hormone sensitivity

    Many people have “normal labs” but still experience significant symptoms. Genetics can help identify sensitivity patterns.

    • PMS: Genetic influences tied to cycle-related symptoms such as irritability, cravings, sleep disruption, bloating, and fatigue.
    • PMDD: Genetic susceptibility patterns associated with stronger mood and anxiety changes around the menstrual cycle. This can support better planning, tracking, and professional support when needed.
    • Hot flashes: Genetics related to temperature regulation and hormone transition symptoms, useful for people approaching perimenopause or menopause.

    This section supports symptom awareness and proactive lifestyle choices that can reduce disruption.

    4) Fertility and reproductive health traits

    This section looks at genetic tendencies related to reproductive health and pregnancy readiness.

    • Infertility: Genetic susceptibility patterns tied to fertility challenges, which may help identify areas to monitor and discuss with a clinician, especially when combined with lifestyle and lab insights.
    • Uterine fibroids: Genetics linked to fibroid susceptibility, which may influence symptom awareness and screening decisions.
    • Pregnancy: Genetic factors that can influence pregnancy-related tendencies and how your body may respond to the physiological demands of pregnancy.

    These insights are not a diagnosis, but they can help you be more proactive with planning and care.

    What you get from this panel

    The Hormone and Fertility Health report helps you:

    • Understand hormone balance tendencies across estrogen, progesterone, and testosterone
    • Personalize strategies for energy, mood, and metabolism support using thyroid genetics
    • Make sense of cycle-related symptoms with insights on PMS, PMDD, and hot flashes
    • Get proactive reproductive health insights related to infertility, uterine fibroids, and pregnancy

    This panel is designed to turn complex hormone biology into clear, practical priorities so you can feel more in control of your health and plan with more confidence.

    Orders

    Find questions related to ordering.

    Does my doctor need to order these tests?

    No. You can order the test directly.

    Can I order these tests for someone else?

    Yes. You can purchase a test for another person. They will need to activate their test kit on our website upon receipt. For minors, parental or guardian consent is required for activation.

    Once someone has successfully responded to PGx registration questions, PlexusDx's Clinician Network will order your test for you.

    How long does it take to receive my results?

    Once we receive your sample at the lab, it takes approximately 10-14 business days to complete the review and analysis for PGx tests and 2-4 weeks for NGx tests.

    Can I use FSA/HSA to cover these tests?

    Yes, the cost of each test is typically reimbursable through both Flexible Spending Accounts (FSA) and Health Savings Accounts (HSA).

    What is Flex and what is their relationship with PlexusDx?

    PlexusDx has partnered with Flex to allow you to use your Health Savings Account (HSA) or Flexible Spending Account (FSA). This means you can now use your HSA or FSA debit card to buy health and wellness tests with pre-tax dollars, resulting in net savings of 30-40%, depending on your tax bracket.

    How do I pay with my HSA or FSA card?

    To use your HSA or FSA debit card, add products to your cart as usual. At checkout, select "Flex | Pay with HSA/FSA" as your payment option, enter your HSA or FSA debit card, and complete your checkout as usual. If you don't see "Flex | Pay with HSA/FSA," you may be in Shop Pay. Select "checkout as guest" to view more payment options.

    What if I don't have my HSA/FSA card available?

    If you don't have your HSA or FSA card handy, still select "Flex | Pay with HSA/FSA" as your payment method. Enter your credit card information and Flex will email you an itemized receipt to submit for reimbursement.

    Why can't I see Flex as a payment method?

    The key here is to make sure you are logged out of Shop Pay. One of the easiest ways to do this is to go through checkout in an incognito window.

    Why is my HSA/FSA card being declined?

    HSA/FSA cards are debit cards, and the most common reason for declines is insufficient funds. Reach out to your HSA/FSA administrator to confirm your balance.

    I submitted my Flex itemized receipt for reimbursement and my FSA requires more information.
    Please forward us the request from your FSA, and we will work with the Flex team to issue you a new receipt.
    Help! I didn't receive an email from Flex with my itemized receipt and/or letter of medical necessity. What should I do?

    Please check your spam folder, as sometimes emails from notifications@withflex.com may be automatically filtered as spam by some email service providers. If you still can't find it, please email support@withflex.com and let them know the email address associated with your order.

    I would like to use multiple HSA/FSA cards to pay for an item. Can I do that?

    No, unfortunately, this isn't a supported feature right now. If there are insufficient funds in a single HSA or FSA account, you can instead enter a credit card on the Flex checkout page. You will receive an itemized receipt and/or Letter of Medical Necessity from Flex, which you can submit for reimbursement.

    Is sales tax covered by HSA/FSA funds, or is it treated separately?

    Sales tax for eligible items is also covered by HSA/FSA funds. If the customer has a split cart, the tax will be divided among the cards based on the items.

    My HSA/FSA Claim was denied. What should I do?

    We strongly recommend checking with your HSA/FSA provider to see if a purchase is eligible prior to completing the purchase. However, if you believe your claim has been wrongly denied, please send over any response from your HSA/FSA provider to us so we can share it with Flex and receive guidance on the next best steps to take. Please note that employer-sponsored FSAs can determine what products are eligible beyond the IRS's guidelines, so it's extremely important to check prior to purchase.

    Can a customer purchase a product now and apply for FSA reimbursement in the next calendar year?

    The ability to apply for FSA reimbursement in a future calendar year depends on the policy of the specific FSA provider. Most FSA administrators require that the purchase be made during the time of coverage. For example, if the FSA coverage is for 2025, all purchases typically need to be made and/or submitted for reimbursement within that coverage period. However, some administrators may have more flexible rules regarding the timing of when the expense occurred. We recommend that customers review their plan policy to confirm the details. Note: Health Savings Accounts (HSAs) are different and generally allow for reimbursement at any time, even in future years.

    Can old (non-Flex) customers use their order confirmation email to apply for HSA/FSA reimbursement?

    Unfortunately, for purchases made without using Flex in the checkout to receive an itemized receipt, it may be difficult to apply for reimbursement. For Health Savings Accounts (HSAs), consumers can use an itemized receipt for reimbursement anytime after they have made the purchase, even if it is many years later. For Flexible Spending Accounts (FSAs), most accounts require that the purchase was made in the calendar year during which the consumer had the FSA, as FSAs typically do not roll over. Some FSAs offer a buffer window, allowing customers additional time to submit receipts for expenses incurred during the previous calendar year.

    Can I speak to a live person?

    Customer Support is available 9am – 5pm EST Monday – Friday.

    877-760-2333

    support@tests.plexusdx.com

    Reporting & Results

    Below are common questions about the test results and reports.

    What is covered by the Precision Wellness Test reports?

    The PlexusDx Precision Wellness Tests cover over 1000 genetic reports related to your overall health. Here is a small sample...

    How you process macronutrients: 

    • Dietary protein
    • Dietary fats
    • Carbohydrates

    Choosing the right types of dietary fat:

    • Saturated fat
    • Omega-3
    • Unsaturated fat

    Getting enough vitamins:

    • Vitamin B6
    • Vitamin E
    • Vitamin D
    • Vitamin B12
    • Folate
    • Vitamin B2
    • Vitamin C
    • Vitamin A
    • Vitamin K

    Getting enough minerals:

    • Zinc
    • Magnesium
    • Iron
    • Potassium
    • Selenium
    • Calcium

    Improving your eating habits:

    • Tendency to overeat
    • Sugar cravings
    • Snacking 
    What steps should I take after getting my test results?

    Receiving your results marks a significant moment in your health journey. They serve as an insightful tool in managing your healthcare effectively. Should you have any inquiries about your results or if you're interested in obtaining clinical advice, please don't hesitate to contact us at results@plexusdx.com.

    Additionally, every client who completes our tests has the opportunity to be connected with either a Clinical Pharmacist or Registered Dietitian through the PlexusDx Network upon request.

    Does this test provide ancestry information?

    This DNA test doesn't offer ancestry details. It focuses solely on how your genes affect your response to specific medications.

    Can this test predict my disease risk?

    This DNA test isn't designed to assess your likelihood of developing diseases, including cancer.

    Privacy

    Below are questions about how we are committed to protecting your privacy and information.

    How does PlexusDx handle my DNA sample?

    Your genetic data is utilized solely for report processing, with no storage or use beyond this requirement. Rest assured, we promptly discard your sample after processing is complete.

    Will you share my data with my insurance or employer?

    No. Your data is for you, and you only.