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MTHFR & Methylation DNA Test
MTHFR & Methylation DNA Test
MTHFR & Methylation DNA Test
MTHFR & Methylation DNA Test
MTHFR & Methylation DNA Test

MTHFR & Methylation DNA Test

$298.00

95+ DNA reports including MTHFR, COMT, BHMT, and Folate Metabolism.

Unlock comprehensive insights with the MTHFR + Methylation Genetic Test, designed to uncover genetic factors affecting detoxification and methylation—key to cognitive health, hormone balance, and overall well-being. Understand crucial genes like MTHFR and MTRR, receive tailored strategies for nutrient absorption and toxin clearance, and access personalized supplement plans and 10,000+ recipes for lasting health optimization.

Pay using HSA/FSA with flex Select Flex at checkout to pay for your HSA/FSA eligible items

Our comprehensive summary reports include:

  • Cutting-edge ancestry-informed polygenic risk scores based on 200M genetic variants
  • Diet, supplement, and lifestyle regimens that supports the best version of yourself
  • Actionable recommendations based on science and 20,000+ clinical studies

Use the Power of Genetics to Take Control of Your Methylation Genes and Detoxificaton Pathways

The PlexusDx Methylation Genes Test provides a personalized roadmap by analyzing key genetic markers like the MTHFR gene, COMT, and many others that influence detoxification, nutrient absorption, and overall health. These insights empower you to make informed choices on diet, supplements, and lifestyle - because health isn’t just about the genes you inherit, it’s about how you optimize them.

Why Precision Health?

One test for the rest of your life

Personalized, actionable advice

Achieve your health goals faster

Lifestyle recommendations, backed by science

Optimize your diet, macronutrients, vitamins and minerals

Supplement advice based on 20,000 clinical studies

Make Targeted Changes Based on Your Methylation Genes

With personalized dietary, supplement, and lifestyle suggestions, you will understand why specific health recommendations are right for your body and tailored to meet your current health needs. Our recommendations are crafted based on your genetic profile because there is no such thing as one-size-fits-all.

40 %
of the U.S. population carries at least one variant of the MTHFR gene, which can reduce enzyme activity by up to 70% in homozygous individuals. This can lead to elevated homocysteine, a marker linked with cardiovascular disease, cognitive decline, and pregnancy complications.
60 %
of methylation imbalances can be improved with targeted diet, supplements, and lifestyle when genetics play a role. By pinpointing genetic “bottlenecks” in folate, B12, or detox pathways, the PlexusDx test helps you follow a plan that’s built for your DNA.
25 %
of people carry changes in the COMT gene, which influence how the body breaks down dopamine, impacting focus, mood, and stress resilience. With the PlexusDx test, you’ll discover if your COMT status may benefit from personalized nutrition or lifestyle support.

How It Works

Discover lifelong insights from one test.

Order

Select your test and purchase directly online. No doctor order required.

Swab

Follow the instructions included in your kit to ensure you collect an effective sample.

Results

Send your completed DNA specimen back and receive your personalized results.

From Sofa to Science

Experience the convenience of Precision Wellness right from your home. Just follow the simple steps included with your kit, and soon your detailed report will arrive at your doorstep.

Your Kit Contains:

1x INSTRUCTIONS & REGISTRATION CODE
1x CHEEK SWAB & TRANSPORT TUBE
1x BIOHAZARD BAG
1x PREPAID RETURN MAILER

FAQs

PlexusDx Methylation Genes Test

The following questions are specific to the PlexusDx Genetic Methylation Test.

What is the PlexusDx Genetic Methylation Test?

The PlexusDx Genetic Methylation Test is an advanced DNA test that analyzes over 200 million genetic variants to generate 95+ personalized reports. It examines key genes like MTHFR, COMT, BHMT, AHCY, MTR, and MTRR that influence detoxification, methylation, hormone balance, and overall wellness.

Which health areas can this DNA test help improve?

By focusing on genetic factors affecting methylation and detoxification, the test provides insights into cognitive health, cardiovascular wellness, hormone balance, immune function, and antioxidant production.

What genes are included in the MTHFR + Methylation Test?

The test examines critical genes such as MTHFR, COMT, BHMT, AHCY, and MTRR, among others, to identify potential genetic bottlenecks that may impact nutrient metabolism, detoxification, and methylation efficiency.

How does the PlexusDx DNA test work?

Once your kit arrives, simply register it online, collect your cheek swab sample, and return it using the prepaid mailer. Your sample is analyzed in a secure lab, and results are delivered online with actionable insights.

What kind of results and recommendations will I receive?

You’ll get detailed, evidence-based reports with supplement and meal plan recommendations, lifestyle tips, and targeted insights for nutrients like Vitamin B12, Riboflavin, and Folate, plus markers like Homocysteine and PEMT activity.

What makes this a “Precision Health” DNA test?

Unlike generic health advice, Precision Health uses your unique DNA to tailor supplement, diet, and lifestyle recommendations that directly address your genetic makeup for optimal performance and long-term wellness.

What sets this test apart from other DNA kits?

The PlexusDx Genetic Methylation Test goes beyond ancestry and basic nutrition insights. It delivers clinically relevant, actionable health strategies backed by over 10,000 clinical trials, helping you turn genetic data into practical wellness outcomes.

What is Nutrigenomics (NGx)?

Nutrigenomic (NGx) testing investigates the influence of genetic makeup on nutrient needs. The generic advice to “eat right and exercise” means different things depending on your genetics. This test can help you outline what changes you can make to your daily habits that can impact your weight, energy, and overall health.

Is Nutrigenomics (NGx) right for me?

Everyone can benefit from knowing how your genetics influence your body’s response to nutrition, providing you with a lifetime of guidance.

Orders

Find questions related to ordering.

Does my doctor need to order these tests?

No. You can order the test directly.

Can I order these tests for someone else?

Yes. You can purchase a test for another person. They will need to activate their test kit on our website upon receipt. For minors, parental or guardian consent is required for activation.

Once someone has successfully responded to PGx registration questions, PlexusDx's Clinician Network will order your test for you.

How long does it take to receive my results?

Once we receive your sample at the lab, it takes approximately 10-14 business days to complete the review and analysis for PGx tests and 2-4 weeks for NGx tests.

Can I use FSA/HSA to cover these tests?

Yes, the cost of each test is typically reimbursable through both Flexible Spending Accounts (FSA) and Health Savings Accounts (HSA).

What is Flex and what is their relationship with PlexusDx?

PlexusDx has partnered with Flex to allow you to use your Health Savings Account (HSA) or Flexible Spending Account (FSA). This means you can now use your HSA or FSA debit card to buy health and wellness tests with pre-tax dollars, resulting in net savings of 30-40%, depending on your tax bracket.

How do I pay with my HSA or FSA card?

To use your HSA or FSA debit card, add products to your cart as usual. At checkout, select "Flex | Pay with HSA/FSA" as your payment option, enter your HSA or FSA debit card, and complete your checkout as usual. If you don't see "Flex | Pay with HSA/FSA," you may be in Shop Pay. Select "checkout as guest" to view more payment options.

What if I don't have my HSA/FSA card available?

If you don't have your HSA or FSA card handy, still select "Flex | Pay with HSA/FSA" as your payment method. Enter your credit card information and Flex will email you an itemized receipt to submit for reimbursement.

Why can't I see Flex as a payment method?

The key here is to make sure you are logged out of Shop Pay. One of the easiest ways to do this is to go through checkout in an incognito window.

Why is my HSA/FSA card being declined?

HSA/FSA cards are debit cards, and the most common reason for declines is insufficient funds. Reach out to your HSA/FSA administrator to confirm your balance.

I submitted my Flex itemized receipt for reimbursement and my FSA requires more information.
Please forward us the request from your FSA, and we will work with the Flex team to issue you a new receipt.
Help! I didn't receive an email from Flex with my itemized receipt and/or letter of medical necessity. What should I do?

Please check your spam folder, as sometimes emails from notifications@withflex.com may be automatically filtered as spam by some email service providers. If you still can't find it, please email support@withflex.com and let them know the email address associated with your order.

I would like to use multiple HSA/FSA cards to pay for an item. Can I do that?

No, unfortunately, this isn't a supported feature right now. If there are insufficient funds in a single HSA or FSA account, you can instead enter a credit card on the Flex checkout page. You will receive an itemized receipt and/or Letter of Medical Necessity from Flex, which you can submit for reimbursement.

Is sales tax covered by HSA/FSA funds, or is it treated separately?

Sales tax for eligible items is also covered by HSA/FSA funds. If the customer has a split cart, the tax will be divided among the cards based on the items.

My HSA/FSA Claim was denied. What should I do?

We strongly recommend checking with your HSA/FSA provider to see if a purchase is eligible prior to completing the purchase. However, if you believe your claim has been wrongly denied, please send over any response from your HSA/FSA provider to us so we can share it with Flex and receive guidance on the next best steps to take. Please note that employer-sponsored FSAs can determine what products are eligible beyond the IRS's guidelines, so it's extremely important to check prior to purchase.

Can a customer purchase a product now and apply for FSA reimbursement in the next calendar year?

The ability to apply for FSA reimbursement in a future calendar year depends on the policy of the specific FSA provider. Most FSA administrators require that the purchase be made during the time of coverage. For example, if the FSA coverage is for 2025, all purchases typically need to be made and/or submitted for reimbursement within that coverage period. However, some administrators may have more flexible rules regarding the timing of when the expense occurred. We recommend that customers review their plan policy to confirm the details. Note: Health Savings Accounts (HSAs) are different and generally allow for reimbursement at any time, even in future years.

Can old (non-Flex) customers use their order confirmation email to apply for HSA/FSA reimbursement?

Unfortunately, for purchases made without using Flex in the checkout to receive an itemized receipt, it may be difficult to apply for reimbursement. For Health Savings Accounts (HSAs), consumers can use an itemized receipt for reimbursement anytime after they have made the purchase, even if it is many years later. For Flexible Spending Accounts (FSAs), most accounts require that the purchase was made in the calendar year during which the consumer had the FSA, as FSAs typically do not roll over. Some FSAs offer a buffer window, allowing customers additional time to submit receipts for expenses incurred during the previous calendar year.

Can I speak to a live person?

Customer Support is available 9am – 5pm EST Monday – Friday.

877-760-2333

support@tests.plexusdx.com

Reporting & Results

Below are common questions about the test results and reports.

What is covered by the Precision Wellness Test reports?

The PlexusDx Precision Wellness Tests cover over 1000 genetic reports related to your overall health. Here is a small sample...

How you process macronutrients: 

  • Dietary protein
  • Dietary fats
  • Carbohydrates

Choosing the right types of dietary fat:

  • Saturated fat
  • Omega-3
  • Unsaturated fat

Getting enough vitamins:

  • Vitamin B6
  • Vitamin E
  • Vitamin D
  • Vitamin B12
  • Folate
  • Vitamin B2
  • Vitamin C
  • Vitamin A
  • Vitamin K

Getting enough minerals:

  • Zinc
  • Magnesium
  • Iron
  • Potassium
  • Selenium
  • Calcium

Improving your eating habits:

  • Tendency to overeat
  • Sugar cravings
  • Snacking 
What steps should I take after getting my test results?

Receiving your results marks a significant moment in your health journey. They serve as an insightful tool in managing your healthcare effectively. Should you have any inquiries about your results or if you're interested in obtaining clinical advice, please don't hesitate to contact us at results@plexusdx.com.

Additionally, every client who completes our tests has the opportunity to be connected with either a Clinical Pharmacist or Registered Dietitian through the PlexusDx Network upon request.

Does this test provide ancestry information?

This DNA test doesn't offer ancestry details. It focuses solely on how your genes affect your response to specific medications.

Can this test predict my disease risk?

This DNA test isn't designed to assess your likelihood of developing diseases, including cancer.

Privacy

Below are questions about how we are committed to protecting your privacy and information.

How does PlexusDx handle my DNA sample?

Your genetic data is utilized solely for report processing, with no storage or use beyond this requirement. Rest assured, we promptly discard your sample after processing is complete.

Will you share my data with my insurance or employer?

No. Your data is for you, and you only.

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Vitamin B12 Blood Test

The Vitamin B12 Blood Test, part of the PlexusDx Methylation Panel, measures cobalamin levels to assess methylation, DNA synthesis, red blood cell health, and nerve function. B12 works with folate to recycle homocysteine, so low levels can raise homocysteine, cause anemia, fatigue, or cognitive issues. Results are influenced by diet, absorption, medications, and lifestyle. Paired with folate and homocysteine, this panel provides a full picture of nutrient balance and methylation health.

 

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Folate (Vitamin B9) Blood Test

Folate (Vitamin B9) Blood Test

The Folate Blood Test, part of the PlexusDx Methylation Panel, measures vitamin B9 levels to assess DNA synthesis, red blood cell health, and methylation balance. Folate helps convert homocysteine to methionine, so low levels can cause elevated homocysteine, anemia, or pregnancy complications. Combined with B12 and homocysteine testing, this panel gives a full picture of nutrient status. At-home collection, fast results, and HSA/FSA eligibility make it easy to monitor your health.

 

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Homocysteine Blood Test

Homocysteine Blood Test

The Homocysteine Blood Test, part of the PlexusDx Methylation Panel, measures homocysteine levels to assess methylation and B-vitamin status. Elevated homocysteine often reflects folate, B12, or B6 deficiency and has been linked with higher cardiovascular risk. Paired with folate and vitamin B12 testing, this panel provides a clear view of nutrient balance and methylation health. At-home collection, fast results, and HSA/FSA eligibility make it simple to monitor and improve your health.

 

👉 Test this biomarker with the PlexusDx Methylation Panel Blood Test