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Cortisol Blood Test

The Cortisol Test measures a key adrenal hormone involved in the stress response, metabolism, blood pressure, inflammation, and blood sugar regulation. Cortisol peaks in the morning and tapers through the day, rising with meals, exercise, or stress. 

Why Measure Cortisol?

  • Stress physiology: Context for fatigue, sleep issues, mood changes, or weight gain.
  • Adrenal overview: Review alongside DHEA-S and thyroid markers for broader endocrine context.

Preparation & Notes

Test at a consistent time of day (often morning). Avoid unusually intense exercise immediately before collection unless advised. Discuss steroid medications with your provider.

How the PlexusDx Test Works

  • At-home collection (finger prick);
  • prepaid return mailer;
  • ~2 business day results;
  • HSA/FSA eligible; no physician order required.

FAQ

Single blood draw vs. diurnal pattern? A single value offers a snapshot; clinical context and additional testing may be used to evaluate daily rhythm.