VLDL Cholesterol Test: Understanding Its Role in Heart Health

Very low-density lipoprotein (VLDL) cholesterol is one of the types of lipoproteins that carry fats through the bloodstream. High levels of VLDL can contribute to plaque buildup in arteries, a condition known as atherosclerosis. This increases the risk of heart disease, stroke, and other vascular problems.

About the Test

Cholesterol, a waxy substance vital for normal cell function, travels through the blood attached to lipoproteins. The main types of lipoproteins are:

  • HDL (high-density lipoprotein): "Good cholesterol" that helps clear cholesterol from the body.
  • LDL (low-density lipoprotein): "Bad cholesterol" that contributes to plaque buildup.
  • VLDL (very low-density lipoprotein): Carries triglycerides and contributes to arterial plaque.

A VLDL cholesterol test estimates the amount of VLDL in the blood, helping doctors assess heart and vascular health.

Purpose of the Test

The VLDL cholesterol test is useful for:

  • Diagnosis: Identifying whether cardiovascular problems may be contributing to health symptoms.
  • Screening: Detecting risks for heart disease or stroke before symptoms appear.
  • Monitoring: Tracking cholesterol levels over time or after beginning treatment.

By estimating VLDL cholesterol, healthcare providers can suggest lifestyle changes, medications, or further testing as needed.

What Does the Test Measure?

VLDL cholesterol is not measured directly. Instead, it is calculated based on triglyceride results, since VLDL particles primarily transport triglycerides in the blood. Results are reported in milligrams per deciliter (mg/dL). Often, this test is part of a broader lipid panel that also reports LDL, HDL, and total cholesterol levels.

When Should You Get a VLDL Cholesterol Test?

The need for VLDL cholesterol testing depends on age, personal and family history, and overall risk factors. Below is a general guide:

Demographic Group Risk Factors Screening Frequency
Children (no risk factors) None Once between ages 9–11; again at 17–21
Children (with risk factors) Family history, obesity, diabetes, etc. Every 1–3 years starting when risk is identified
Adolescents & Adults (with risk factors) Diabetes, high blood pressure, family history At least every 5 years; more often if needed
Males (20–45) / Females (20–55) with no risk factors None Every 4–6 years
Males (45–65) / Females (55–65) with no risk factors None Every 1–2 years
Adults over 65 With or without risk factors Annually