Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

Constipation: Your bowels refuse to move when you feel the need to go?

Constipation which results in infrequent bowel movements or difficulty in stool passage develops into additional health complications. Ancient medical documents suggested diseases originated from 'decomposing intestinal material,' but contemporary understanding shows that constipation does not cause all illnesses yet has a substantial effect on both health and well-being. The United States records approximately 2.5 million doctor visits each year due to severe constipation which demonstrates how widespread and impactful this condition is. Diets and genetics both play major roles in affecting bowel movement patterns. The presence of a particular AHR gene variant can cause reduced water consumption which may lead to dehydration and constipation. Learning about genetic factors in constipation can help create effective management strategies. According to genetic research findings the genes that cause constipation appear to be the same as those responsible for irritable bowel syndrome (IBS). Dehydration along with a low-fiber diet and insufficient physical activity contribute to constipation risk factors along with intestinal blockages and nerve muscle or hormonal problems as well as age gender and certain medications. Because about one-quarter of people struggle with constipation during their lives, modifying risk factors is essential to achieve regular bowel movements. The condition known as constipation presents through infrequent bowel movements along with painful or difficult defecation accompanied by hard stools and an enduring sensation of incomplete evacuation. A healthy digestive system benefits from lifestyle changes that include more fiber consumption and adequate hydration combined with physical exercise and stress management while promptly responding to defecation urges. People who have genetic predispositions or experience frequent constipation symptoms can lower their total risk through proactive management of factors that they can control. Dietary adjustments and lifestyle changes help some people manage constipation while others need medications or surgical interventions to achieve effective results. Bowel habits vary between individuals because of genetic differences which demonstrate the need for personalized bowel health treatments. The understanding of genetic factors in constipation enables people to make educated health choices. People can enhance their bowel function and general health by utilizing personalized suggestions derived from genetic analysis. Explore your genetic predispositions and get personalized recommendations using Precision Health & Wellness tests from PlexusDx available at PlexusDx.com and on Amazon and Walmart. Take charge of your gut health today!

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.

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