Yes — genetic testing can guide hormone replacement, but "guide" means something more precise than "predict" or "prescribe." The Precision Peptide Genetic Test maps six Reproductive Health insights across 14 pathways, 49 peptides, and 150+ genetic insights that give providers and patients a defined biological starting point before any hormone support protocol begins.

MTHFR variants affect HRT in three ways: by constraining the SAMe supply that estrogen clearance depends on, by elevating homocysteine as a cardiovascular monitoring variable, and by determining which folate form will actually support your methylation cycle on protocol. The Precision Peptide Genetic Test analyzes MTHFR as part of 14 pathways, 49 peptides, and 150+ genetic insights.

The Precision Peptide Genetic Test analyzes GSTM1 and GSTT1 — the glutathione S-transferase genes whose null deletions eliminate the tertiary Phase 2 backstop against reactive estrogen quinones. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your GSTM1 and GSTT1 deletion status determines whether glutathione conjugation is available when COMT and SULT1A1 clearance is insufficient.

The Precision Peptide Genetic Test analyzes ESR1 and ESR2 — the two estrogen receptor genes that determine how sensitively your tissues respond to circulating estrogen. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your estrogen receptor variants explain why the same estradiol level produces very different biological effects in different women.

The Precision Peptide Genetic Test analyzes MTHFR C677T and A1298C — the variants that set your methylation capacity and determine how efficiently your body produces the SAMe that estrogen clearance depends on. Part of 14 pathways, 49 peptides, and 150+ genetic insights, MTHFR is the upstream genetic variable that connects the methylation cycle to women's hormone balance.

The Precision Peptide Genetic Test analyzes COMT Val158Met — the single variant that most directly determines how quickly your body clears catechol estrogens in Phase 2 metabolism. Part of 14 pathways, 49 peptides, and 150+ genetic insights, your COMT genotype explains why two women with identical estrogen levels can experience hormonal balance very differently.

Genetics shapes estrogen in men through four pathways: how much testosterone converts to estradiol (CYP19A1), how efficiently it clears (COMT, MTHFR), how sensitively tissues respond (ESR1), and how much substrate is available (SHBG, SRD5A2). The Precision Peptide Genetic Test maps all these variables across 14 pathways and 150+ genetic insights.

The Precision Peptide Genetic Test analyzes MTHFR C677T and A1298C — the variants that determine your methylation capacity and its downstream effects on estrogen clearance, homocysteine levels, and hormone metabolism. Part of 14 pathways and 150+ genetic insights across 49 peptides, MTHFR is the genetic variable connecting methylation to the male hormone system.

The Precision Peptide Genetic Test analyzes six Reproductive Health genes that directly influence testosterone levels, conversion, and signaling — including SHBG, CYP19A1, AR, SRD5A2, LHCGR, and CYP17A1. Part of 14 pathways and 150+ genetic insights across 49 peptides, these variants explain why testosterone behaves differently in different men.

The Precision Peptide Genetic Test analyzes LH and FSH receptor variants — the genes governing how sensitively your HPTA axis signals testosterone production and sperm health. Part of 14 pathways and 150+ genetic insights across 49 peptides, your HPTA genetics help explain why fertility preservation strategies matter differently for different men on androgen-pathway protocols.

DHT is the most potent male androgen, and how much you make and how strongly you respond to it are shaped by genes like SRD5A2 and the androgen receptor gene AR. This article explains DHT's role in male sexual health, the genetic factors behind imbalance, and how pathway-level insight adds context.