Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

Blood Clots and Genetic Predispositions

Have you ever wondered why some people develop blood clots more often than others? The genetic composition of individuals probably contains the solution to this question. This blog post investigates thrombosis through genetic analysis to demonstrate how people's genetic factors influence their risks of developing blood clots. Thrombosis creates severe health risks because blood clots develop within the blood vessels and may cause extensive effects throughout the body. When blood clots obstruct circulation they lower oxygen levels which could lead to tissue damage. Thrombosis occurs as either venous thrombosis such as deep vein thrombosis or arterial thrombosis which includes coronary thrombosis depending on the location of the blood clot formation. The bodily location and nature of blood clots affect how thrombosis presents clinically. Thrombosis normally presents with symptoms of pain in addition to swelling redness and warmth at the affected area. When thrombosis becomes particularly severe it results in chest pain and symptoms that mimic a stroke while also causing other potentially fatal complications. The development of thrombosis in a person is largely determined by their genetic makeup. Research shows that genetic factors explain approximately 50% of the differences in thrombosis risk between people. Certain genetic differences predispose some people to form blood clots while others with varied genetic makeups do not face the same risk. The likelihood of thrombosis develops from genetic influences in combination with other factors that modify its probability. The chances of developing blood clots increase when prolonged immobility and surgery combine with injuries and medications and then mix with smoking and age along with pregnancy and obesity. Medical professionals can tailor prevention methods and treatment plans for thrombosis by understanding its genetic basis to address individual risk factors. PlexusDx's genetic testing services enable users to learn about their genetic risks which helps them establish personalized health strategies. To prevent blood clots you can lower your thrombosis risk by following these practical tips. Avoid long periods of physical inactivity by staying in motion throughout your day. Maintain a healthy weight and lifestyle. Adhere to your healthcare provider's suggested treatment plan when managing any existing health conditions. Patients should discuss their blood clot concerns with their doctor before starting any new medication or surgical procedure. The development of thrombosis occurs through the interaction of various genetic factors alongside environmental influences. By combining knowledge of genetic blood clotting traits with active risk factor management we empower ourselves to control our health. Use PlexusDx Precision Health & Wellness tests to identify your genetic predispositions and start early preventative health actions. Visit PlexusDx.com to explore genetic testing benefits while shopping through Amazon or Walmart for better-informed health choices.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.

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