Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.
Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.
Living with Eczema
Managing eczema requires daily effort if you are living with this condition. The skin condition known as eczema produces inflamed and itchy skin which represents a widespread health issue affecting numerous people particularly children. Eczema remains misunderstood by many people who falsely think it can spread from person to person. The development of eczema stems from combined effects of immune system activity, skin responses, and environmental factors that differ between individuals. Effective eczema management depends on identifying unique individual triggers. Patients receiving allergy tests from their dermatologists may experience relief but others struggle to identify specific triggers. Managing eczema triggers requires a lengthy and difficult journey because individual sensitivities change over time. By studying genetic factors researchers can potentially discover new methods to understand eczema triggers. The genetic makeup of individuals determines their responses to eczema triggers. Genetic mutations in FLG and CLDN1 genes determine individual sensitivity levels towards various eczema triggers. The FLG gene generates filaggrin which plays an essential role in maintaining skin barrier integrity. Certain genetic variants can increase eczema trigger sensitivity but proper skincare with moisturizers and colloidal oatmeal can build up skin barriers against these genetic effects. Mutations in the CLDN1 gene make people more susceptible to developing eczema when exposed to fragrances or jewelry. Analyzing genetic predispositions helps develop targeted eczema management approaches for individual patients. Genetic studies demonstrate that genetic factors account for up to 75% of the variance seen in how individuals develop eczema. People who have a high genetic predisposition towards eczema must be particularly careful to steer clear of potential triggers such as allergens, cold weather conditions, infections, skin irritants and stress. Access to your genetic risk score from over 7,000 genetic variants enables you to make informed skin health protection choices. Eczema symptoms include dry skin and itchy red rashes that typically show up in specific body parts. Eczema affects up to one-third of children while it continues to affect adult populations but less commonly. Allergens together with dry air infections skin irritants and stress conditions worsen eczema symptoms. People who have eczema face a higher risk of skin infections because their skin barriers are weakened. Eczema symptoms require management through moisturizing treatments, humidifiers, topical medications while avoiding substances that can irritate the skin. Good skincare practices including nail trimming and covering affected areas are essential to prevent scratching and additional skin damage. Studies of genetic patterns show that eczema shares genetic connections with asthma and both hay fever and food allergies. People who have one of these conditions tend to develop additional ones because of common genetic elements that link them together. The genetic components of eczema affect skin barrier integrity as well as inflammatory and immune system responses which reveal the connections among these medical conditions. The genetic understanding of eczema provides important knowledge for those affected by this condition. Knowing the genetic basis of eczema triggers and symptoms enables you to take effective measures for managing your condition. Take advantage of PlexusDx Precision Health & Wellness tests which use your genetic profile to deliver personalized health recommendations. Control your skin health by choosing informed decisions that support your overall well-being.
Frequently Asked Questions
Is eczema contagious?
No. The post says eczema remains misunderstood by many people who falsely think it can spread from person to person. It describes the condition as developing from the combined effects of immune system activity, skin responses and environmental factors that differ between individuals. That is also why triggers are so personal and why identifying your own is central to managing it.
What does the FLG gene do for the skin?
FLG generates filaggrin, which the post says plays an essential role in maintaining skin barrier integrity. Variants in the gene can increase sensitivity to eczema triggers by weakening that barrier. The post's practical counterpoint is that proper skincare using moisturisers and colloidal oatmeal can help build the skin barrier back up, so a variant is not the end of the story.
Which conditions share genetic links with eczema?
Asthma, hay fever and food allergies. The post says genetic studies show eczema shares genetic connections with all three, and that people who have one of these conditions tend to develop others because of common underlying genetic elements. It attributes the overlap to shared effects on skin barrier integrity and on inflammatory and immune responses.
Which triggers should someone with a strong eczema predisposition avoid?
The post names allergens, cold weather conditions, infections, skin irritants and stress as the triggers to steer clear of, and elsewhere adds dry air. It also notes that the CLDN1 gene has been studied in connection with reactions to fragrances and jewellery. Because individual sensitivities change over time, the post treats trigger identification as an ongoing process rather than a one-off exercise.
How does the post suggest preventing damage from scratching?
Through good skincare practices including trimming nails and covering affected areas, which the post says are essential to prevent scratching and further skin damage. That matters because it also notes people with eczema face a higher risk of skin infections due to their weakened skin barrier. Moisturising treatments, humidifiers and topical medications round out its symptom management suggestions.
Medical and Editorial Standards
Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.
Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.
Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.
Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.
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