Last reviewed: May 12, 2026
Last updated: May 12, 2026
Written by:
Jay Hastings
,
CEO of PlexusDx
Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.
Medically reviewed by:
Jayden Lee, PharmD, EMBA
Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.
The Role of Genetics in Red Blood Cell Health
The study of genetics reveals its effects on our health and it becomes evident that red blood cells serve a fundamental role in sustaining our bodily functions. Microscopic red blood cells function as essential transporters of oxygen throughout our circulatory system delivering it from our lungs to every part of our body. What occurs when the equilibrium of these essential cells becomes disturbed? We will examine how genetic factors determine the quantity and operation of red blood cells within the captivating field of hematology.
Our body contains the highest number of blood cells in the form of red blood cells known as erythrocytes. Red blood cells deliver oxygen to body tissues and organs while also removing carbon dioxide that is produced as a cellular waste product. Oxygen-dependent cellular respiration and energy production make this process vital for life sustenance. The bone marrow produces red blood cells through a process called erythropoiesis which relies on nutrients including iron, vitamin B12, and folate for successful development. The production of hemoglobin depends on these nutrients because hemoglobin allows red blood cells to attach to and move oxygen throughout the body. An insufficient supply of essential nutrients results in impaired red blood cell production which causes anemia to develop.
A low count of red blood cells defines anemia which significantly affects both health status and quality of life. People with anemia often experience fatigue and weakness along with pale skin and breathing difficulties which may cause dizziness and cold hands and feet. Anemia arises from nutrient deficiencies and blood loss as well as certain health conditions which underscores the necessity of treatment directed at the fundamental cause under medical supervision. Polycythemia represents an excessive amount of red blood cells which carries its own health risks. Living at high altitudes along with smoking and heart or lung diseases and dehydration can cause the body to produce more red blood cells. People with elevated red blood cell counts often suffer from fatigue, itchy skin, nosebleeds, headaches and shortness of breath along with an increased risk of developing blood clots. It is important to seek medical evaluation and management if you experience related symptoms and discover you have high red blood cell levels.
Our genetic makeup significantly influences the number of red blood cells produced by our bodies. Research findings show that genetic factors account for as much as 65% of the differences in red blood cell counts between people. Genetic differences affect both the number and functionality of red blood cells which may lead to changes in health status and disease vulnerability. The complex relationship between our genetic makeup and red blood cells highlights how essential it is to recognize our genetic predispositions for effective health management. Services like PlexusDx enable individuals to learn important details about their red blood cell count through genetic insights which affect their health status. Gaining knowledge about red blood cell imbalances allows you to take active measures that lead to better health and vitality. Today begin your health management journey by checking out PlexusDx Precision Health & Wellness tests which you can find at PlexusDx.com and also purchase through Amazon and Walmart. The information encoded in your genes provides vital insights into your health which helps you make better health decisions when working with your doctor. Utilize genetic insights to start a personalized health optimization journey that matches your specific genetic composition.
Frequently Asked Questions
What do red blood cells do besides carrying oxygen?
They also remove carbon dioxide, the waste product cells produce. The post describes erythrocytes as the most numerous blood cells in the body, delivering oxygen from the lungs to tissues and organs while clearing that waste gas in the other direction. This exchange supports oxygen-dependent cellular respiration and energy production, which is why the post calls the process vital for sustaining life.
Which nutrients does red blood cell production depend on?
Iron, vitamin B12 and folate. The post explains that bone marrow produces red blood cells through erythropoiesis, and that these nutrients are required for hemoglobin production, since hemoglobin is what lets red blood cells bind and move oxygen. An insufficient supply impairs red blood cell production and leads to anemia, which is why nutrient status matters so much here.
What is polycythemia and what can cause it?
Polycythemia is an excessive number of red blood cells, and the post treats it as carrying its own health risks rather than being a bonus. Causes it lists include living at high altitudes, smoking, heart or lung diseases, and dehydration. The post advises seeking medical evaluation and management if you have related symptoms and discover your red blood cell levels are high.
What share of differences in red blood cell counts does the post attribute to genetics?
The post says research findings show genetic factors account for as much as 65 percent of the differences in red blood cell counts between people, and that genetic differences affect both the number and functionality of those cells. It does not name any individual gene behind that figure. Treat it as background: an actual red blood cell count comes from a blood test ordered by a clinician.
Why does the post stress medical evaluation for an abnormal red blood cell count?
Because both directions carry consequences and both have many possible causes. The post links a low count to fatigue, weakness, pale skin, breathing difficulties, dizziness and cold hands and feet, and a high count to fatigue, itchy skin, nosebleeds, headaches, shortness of breath and increased clot risk. It says treatment should be directed at the fundamental cause under medical supervision.
Medical and Editorial Standards
Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.
Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.
Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.
Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.
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