Last reviewed: May 12, 2026 Last updated: May 12, 2026

Written by: Jay Hastings , CEO of PlexusDx

Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.

Medically reviewed by: Jayden Lee, PharmD, EMBA

Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.

PlexusDx delivers genetic analysis through personalized health reports

to show how certain genetic traits affect overall health. Today we explore paresthesia which presents as sensations of tingling or numbness along with 'pins and needles' feelings. This exploration of paresthesia's genetic basis will help us comprehend how this symptom functions as an indicator for your overall health. Paresthesia frequently develops during routine activities such as remaining seated in one position for an extended period. Sustained sensations can indicate deeper medical problems that might include nerve damage or systemic illnesses. Paresthesia serves as a symptom rather than a disease because it indicates an underlying condition that disrupts nerve function or integrity. Paresthesia stems from multiple factors including nerve irritation and disruptions in blood circulation alongside irregular nerve signaling. The characteristic tingling or numbness sensations of paresthesia develop as a result of these disruptions. Persistent paresthesia requires extensive medical assessment to determine possible underlying conditions like diabetes, multiple sclerosis, nutritional deficiencies, or toxic exposures. Effective treatment of chronic paresthesia necessitates addressing its underlying causes through comprehensive management strategies. The treatment for chronic paresthesia might require adjustments to daily habits while utilizing specific medications and surgical procedures to relieve nerve compression in advanced situations. Knowledge of genetic factors related to paresthesia enables individuals to comprehend their predispositions better while empowering them to protect their nerve health through proactive measures. People interested in the genetic aspects of paresthesia can use PlexusDx Precision Health & Wellness tests to study System Function & Longevity and obtain reports about their genetic traits that affect nerve health. These tests allow individuals to understand their genetic predispositions towards paresthesia and various health factors. Paresthesia reveals the complex relationship between genetic makeup and nerve functionality. The data from PlexusDx's genetic tests enables people to make informed health decisions through increased knowledge of their well-being. Begin your journey to improved health by discovering Precision Health & Wellness tests through PlexusDx.com alongside Amazon and Walmart. Learn the hidden details of your genetic structure to start your path to enhanced wellness and vitality.

Medical and Editorial Standards

Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.

Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.

Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.

Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.

Real prescribers. Published prices. No surprises.

Licensed providers in all 50 states. Online intake. No insurance, no membership required.

Start My Intake

~60 seconds · $0 charged until your provider approves