Last reviewed: May 12, 2026
Last updated: May 12, 2026
Written by:
Jay Hastings
,
CEO of PlexusDx
Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations. He has more than 20 years of experience across healthcare innovation, genomics, laboratory operations, healthcare investing, and strategic finance. His work has included scaling healthcare startups, leading CLIA lab integrations, and helping expand consumer access to precision health tools.
Medically reviewed by:
Jayden Lee, PharmD, EMBA
Jayden Lee, PharmD, EMBA, is the PlexusDx Medical Science Liaison with a PharmD and MBA specializing in pharmacogenomics and clinical product development, with a proven ability to bridge the gap between genomic research and practical patient outcomes. Dr. Lee has more than 10 years of professional experience in clinical pharmacy, academia, and research.
Mercury and Your Health
The toxic heavy metal mercury appears throughout our environment starting from soil all the way to seafood. This blog post explores how genetic factors affect our ability to detoxify from mercury and reveals the multiple health effects resulting from mercury exposure.
Mercury Exposure
Everyday sources carry mercury which creates underestimated health hazards. Large fish such as tuna, shark, and swordfish serve as major sources of mercury exposure through seafood consumption. Dental amalgams combined with occupational exposures like gold mining serve as additional sources of mercury intake. A number of vaccines carry minimal amounts of mercury through thimerosal while health officials claim its safety and provide thimerosal-free options. The prolonged exposure to mercury can lead to severe health problems such as depression and cognitive decline along with heart disease and kidney damage.
The hazardous impact of mercury on human health emphasizes the necessity of learning how our bodies eliminate this toxic element. The body detoxifies mercury mainly through glutathione which functions as the "master antioxidant". Glutathione attaches to mercury to convert it into safer chemicals which the body can then remove. Genetic differences in genes that control glutathione synthesis and function can modify how efficiently a person detoxifies mercury. The GCLC gene produces an enzyme essential for the creation of glutathione. The gene variant rs761142-A shows a connection to increased mercury concentrations in mother's hair. Research indicates that pregnant women with elevated blood mercury levels experience developmental complications in their children. The GSTP1 gene produces an enzyme that helps bind toxins but contains the rs1138272-T variant which results in increased mercury concentrations in both blood and hair samples. People with the "null" variant of the GSTM1 gene tend to show increased mercury levels in their blood and hair samples. A specific gene variant determines glutathione activity which regulates how well the body detoxifies itself. The rs366631 "AA" genotype in your genetic profile suggests you carry this variant and need to monitor mercury exposure closely.
The interplay between genetic variants and mercury levels remains complicated and remains not completely understood. The understanding of mercury detoxification is clouded by inconsistent research findings which are further complicated by dietary habits and environmental influences. Understanding your genetic predispositions can reveal important information about how sensitive you are to mercury. People who understand their genetic ability to detoxify mercury can make better choices for their health. The Precision Health & Wellness tests from PlexusDx which you can find on PlexusDx.com as well as Amazon and Walmart provide valuable insights into your genetic profile and potential risk factors. Optimize your health outcomes by using genetic testing insights to manage your well-being.
Medical and Editorial Standards
Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims.
Sources and evidence: PlexusDx educational content is developed using peer-reviewed research, clinical literature, reputable medical references, and, where applicable, public health or regulatory guidance. References are included at the end of the article when scientific, medical, or health-related claims are discussed.
Commercial transparency: PlexusDx offers genetic testing, blood biomarker testing, personalized supplement recommendations, and related precision wellness services. Product mentions are intended to help readers understand available options and should not be interpreted as medical advice.
Important disclaimer: PlexusDx educational content is for informational purposes only and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before making decisions about medications, supplements, genetic testing, lab testing, or health-related care.
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