HLA-DQ variants, encoded by HLA-DQA1 and HLA-DQB1, are among the strongest inherited risk factors for celiac disease and type 1 diabetes, with 90 to 95 percent of celiac patients carrying HLA-DQ2. This article explains the disease links and why a positive result rules conditions in but rarely diagnoses them.

High basophil counts (basophilia) can signal allergic, thyroid, inflammatory, or bone-marrow processes such as myeloproliferative neoplasms. Genes including JAK2 and KIT shape the biology behind elevated basophils. Learn what a high reading means and how genetics adds pathway-level context to the conversation with your provider.

Low IL-10 — the body's main anti-inflammatory cytokine — is linked to inflammatory bowel disease, rheumatoid arthritis, and cardiovascular inflammation. The IL10 promoter variant rs1800896 helps set how much you produce. Learn what low IL-10 means and how pathway-level genetic insight clarifies your inflammatory biology.

Alopecia areata is an autoimmune hair loss condition with strong genetic roots in the HLA region. Learn how HLA-DQA2, HLA-DQB1, and HLA-DRB1 variants raise risk, why immune genes like CTLA4 and PTPN22 also contribute, and what inherited risk does — and does not — tell you about the condition.

Chlamydia susceptibility is shaped partly by immune-system genes such as TLR4 and IL10, which influence how the body responds to Chlamydia trachomatis. Learn what research shows about genetic factors, the protection methods that matter most, and how pathway-level insight from PlexusDx fits in.

Myocarditis is inflammation of the heart muscle, often triggered by viral infection, with symptoms from chest pain to palpitations. This article explains the signs, causes, and the DSP, TTN, and LMNA gene variants researchers link to susceptibility, plus what pathway-level genetic insight can and cannot tell you.

The IL23R gene controls the IL-23/IL-17 immune axis, and its variants shift risk across inflammatory bowel disease, psoriasis, ankylosing spondylitis, and psoriatic arthritis. Learn how the rs11209026 (Arg381Gln) variant can be protective and how genetics adds pathway-level context to autoimmune risk.

The PTPN22 gene variant R620W (rs2476601) is one of the broadest autoimmune-associated variants, linked to type 1 diabetes, rheumatoid arthritis, lupus, and thyroid conditions. This article explains how one immune-brake gene touches so many diseases, what a result means, and what genetic insight adds.

Recurrent strep infections are shaped by immune genetics, including HLA-DQB1 and HLA-DRB1 variants that affect antibody recognition and MBL2 variants that lower innate bacterial clearance. This article explains why some people catch strep repeatedly and how genetic insight adds context for a provider conversation.

Chronic inflammation is shaped partly by your genes. Learn how variants in TNF, IL6, NFKB1, and the CRP biomarker influence your inflammatory baseline, which lifestyle levers matter, and how PlexusDx testing provides pathway-level genetic insight — for education, not diagnosis or treatment.